|
Binding affinity towards human 5-hydroxytryptamine 1 receptor
|
None
|
830.0
nM
|
|
|
In vitro binding affinity for 5-hydroxytryptamine 2 receptor
|
None
|
220.0
nM
|
|
|
Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor
|
None
|
120.0
nM
|
|
|
Binding affinity for human 5-hydroxytryptamine 2A receptor
|
Homo sapiens
|
82.0
nM
|
|
|
Binding affinity towards human alpha-1 adrenergic receptor
|
None
|
58.0
nM
|
|
|
Binding affinity towards human alpha-1 adrenergic receptor
|
None
|
4.5
nM
|
|
|
Binding affinity towards human alpha-2 adrenergic receptor
|
None
|
87.0
nM
|
|
|
Binding affinity towards human Dopamine receptor D2
|
None
|
310.0
nM
|
|
|
Binding affinity towards human D2 dopamine receptor.
|
None
|
69.0
nM
|
|
|
Binding affinity against dopamine receptor D1
|
None
|
390.0
nM
|
|
|
In vitro binding affinity for Dopamine receptor D2
|
None
|
63.1
nM
|
|
|
Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.
|
None
|
330.0
nM
|
|
|
Binding affinity towards human dopamine receptor D3
|
None
|
340.0
nM
|
|
|
Binding affinity towards human Dopamine receptor D3
|
None
|
650.0
nM
|
|
|
Binding affinity towards human histamine H1 receptor
|
None
|
19.0
nM
|
|
|
Binding affinity towards human H1 receptor
|
None
|
21.0
nM
|
|
|
Binding affinity towards human M1 receptor.
|
None
|
56.0
nM
|
|
|
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells
|
Homo sapiens
|
251.19
nM
|
|
|
Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cells
|
Homo sapiens
|
79.43
nM
|
|
|
Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells
|
Homo sapiens
|
63.1
nM
|
|
|
Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cells
|
Homo sapiens
|
251.19
nM
|
|
|
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
|
Homo sapiens
|
63.1
nM
|
|
|
Displacement of [3H]pirenzepine from human M1 receptor expressed in CHO cells
|
Homo sapiens
|
398.11
nM
|
|
|
Displacement of [3H]4-DAMP from human M4 receptor expressed in CHO cells
|
Homo sapiens
|
125.89
nM
|
|
|
Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortex
|
Rattus norvegicus
|
12.59
nM
|
|
|
Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum
|
Cavia porcellus
|
39.81
nM
|
|
|
Displacement of [3H]mepyramine from H1R in rat brain
|
Rattus norvegicus
|
40.0
nM
|
|
|
Binding affinity to human cloned muscarinic M1 receptor
|
Homo sapiens
|
100.0
nM
|
|
|
Binding affinity to human cloned dopamine D2 receptor
|
Homo sapiens
|
180.0
nM
|
|
|
Binding affinity to human cloned dopamine D3 receptor
|
Homo sapiens
|
320.0
nM
|
|
|
Binding affinity to human cloned histamine H1 receptor
|
Homo sapiens
|
8.7
nM
|
|
|
Binding affinity to human cloned 5HT1A receptor
|
Homo sapiens
|
230.0
nM
|
|
|
Binding affinity to human cloned 5HT2A receptor
|
Homo sapiens
|
220.0
nM
|
|
|
Binding affinity to rat NET
|
Rattus norvegicus
|
680.0
nM
|
|
|
Displacement of [3H]8OH-DPAT from 5HT1A in rat brain cerebral cortex after 15 mins by scintillation counting
|
Rattus norvegicus
|
230.0
nM
|
|
|
Displacement of [3H]ketanserin from 5HT2A in rat brain cerebral cortex after 20 mins by scintillation counting
|
Rattus norvegicus
|
220.0
nM
|
|
|
Displacement of [3H]spiperone from dopamine D2 receptor in rat striatum tissue after 20 mins by scintillation counting
|
Rattus norvegicus
|
180.0
nM
|
|
|
DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)
|
None
|
629.8
nM
|
|
|
DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)
|
None
|
220.2
nM
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)
|
None
|
815.1
nM
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
|
None
|
117.8
nM
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)
|
None
|
33.6
nM
|
|
|
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
|
Rattus norvegicus
|
86.2
nM
|
|
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
|
Rattus norvegicus
|
34.9
nM
|
|
|
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
|
Rattus norvegicus
|
24.5
nM
|
|
DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)
|
Rattus norvegicus
|
13.6
nM
|
|
|
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
|
None
|
96.6
nM
|
|
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
|
None
|
47.5
nM
|
|
|
DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)
|
None
|
934.3
nM
|
|
|
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
|
None
|
100.3
nM
|
|
DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)
|
None
|
45.8
nM
|
|
|
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
|
None
|
420.8
nM
|
|
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
|
None
|
61.1
nM
|
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
|
None
|
213.5
nM
|
|
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
|
None
|
135.9
nM
|
|
|
DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)
|
None
|
963.9
nM
|
|
|
DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
|
None
|
429.3
nM
|
|
DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)
|
None
|
214.6
nM
|
|
|
DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)
|
None
|
443.3
nM
|
|
|
DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
|
None
|
395.1
nM
|
|
|
DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)
|
None
|
39.6
nM
|
|
DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)
|
None
|
4.599
nM
|
|
|
Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting
|
Homo sapiens
|
101.0
nM
|
|
|
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting
|
Homo sapiens
|
125.0
nM
|
|
|
Displacement of [3H]-MK-912 from human cloned adrenergic alpha2A receptor expressed in insect Sf9 cells at 10'-6 M after 60 mins by liquid scintillation counting
|
Homo sapiens
|
23.0
%
|
|
|
Binding affinity to adrenergic alpha1A receptor (unknown origin) by PDSP assay
|
Homo sapiens
|
100.0
nM
|
|
|
Binding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assay
|
Homo sapiens
|
100.0
nM
|
|
|
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
|
Homo sapiens
|
100.0
nM
|
|
|
Binding affinity to H1 histamine receptor (unknown origin) by PDSP assay
|
Homo sapiens
|
10.0
nM
|
|
|
Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
|
Homo sapiens
|
202.0
nM
|
|
|
Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
|
Homo sapiens
|
10.0
nM
|
|
|
Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
|
Homo sapiens
|
400.0
nM
|
|
|
Binding Assay: Binding assay using 5-HT2A, Dopamine D2, SERT, αA1, 5-HT2C and H1 Receptors.
|
Homo sapiens
|
20.0
nM
|
|
|
Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in human brain tissue incubated for 30 mins by scintillation counting analysis
|
Homo sapiens
|
300.0
nM
|
|
|
Displacement of [3H]Ketanserin from 5-HT2A receptor in human brain tissue incubated for 60 mins by scintillation counting analysis
|
Homo sapiens
|
31.0
nM
|
|
|
Binding affinity to H1 histamine receptor (unknown origin)
|
Homo sapiens
|
11.0
nM
|
|
|
Binding affinity to adrenergic alpha1 receptor (unknown origin)
|
Homo sapiens
|
7.0
nM
|
|
|
Binding affinity to human dopamine D2 receptor
|
Homo sapiens
|
140.0
nM
|
|
|
Binding affinity to human 5HT1A receptor
|
Homo sapiens
|
180.0
nM
|
|
|
Binding affinity to human 5HT2A receptor
|
Homo sapiens
|
220.0
nM
|
|
|
Displacement of [3H]-ketanserin from human human 5-HT2A receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method
|
Homo sapiens
|
120.23
nM
|
|
|
Displacement of [3H]-methylspiperone from human D2 receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method
|
Homo sapiens
|
309.03
nM
|
|
|
Displacement of [3H]-scopolamine from human recombinant muscarinic M1 receptor expressed in human recombinant CHO-K1 cells at 1 uM incubated for 120 mins by solid scintillation counting method relative to control
|
Homo sapiens
|
88.0
%
|
|
|
Displacement of [3H]-pyrilamine from human recombinant histamine H1 receptor expressed in human recombinant CHO-K1 cells at 1 uM incubated for 60 mins by solid scintillation counting method relative to control
|
Homo sapiens
|
76.0
%
|
|
|
Displacement of [3H]-prazosin from rat cortex membrane alpha1 adrenergic receptor expressed in human recombinant CHO-K1 cells at 1 uM after 30 mins by solid scintillation counting method relative to control
|
Rattus norvegicus
|
75.0
%
|
|
