PROPAFENONE

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Search structure


Synonyms	GNF-Pf-4594 Propafenon hexal Propafenone Rythmol
Status
Molecule Category	Free-form
ATC	C01BC03
UNII	68IQX3T69U
EPA CompTox	DTXSID9045184

Structure


InChI Key	JWHAUXFOSRPERK-UHFFFAOYSA-N
Smiles	CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1
InChI	InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H27NO3
Molecular Weight	341.45
AlogP	3.24
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	11.0
Polar Surface Area	58.56
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	25.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	-	-	-	12-25
Ion channel Other ion channel Pore-forming toxins (proteins and peptides)	-	-	-	-	0
Ion channel Voltage-gated ion channel Cyclic nucleotide-regulated channel	-	-	-	-	47.8-54.6
Ion channel Voltage-gated ion channel Potassium channels Inwardly rectifying potassium channel	-	-	-	-	0.2-89.6
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	440-800	-	-	44.1-96.9
Ion channel Voltage-gated ion channel Voltage-gated calcium channel	-	-	-	-	60.2-72.5
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	93.4-97.1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	83.8
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	320-329	331.13	-	-	-
Transporter Primary active transporter ATP-binding cassette ABCC subfamily	-	-	-	-	89.6

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	329	331.13	-	-	12-96.9
Oryctolagus cuniculus	-	-	-	-	0
Plasmodium falciparum K1	200-920	-	-	-	-

Environmental Exposure

Environmental Exposure Map

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia

Cross References

Resources	Reference
ChEBI	63619
ChEMBL	CHEMBL631
DrugBank	DB01182
DrugCentral	2291
FDA SRS	68IQX3T69U
Human Metabolome Database	HMDB0015313
Guide to Pharmacology	2561
KEGG	C07381
PharmGKB	PA451131
PubChem	4932
SureChEMBL	SCHEMBL16730120

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025