Inhibition of collagenase-1 (Matrix metalloprotease-1)
|
Homo sapiens
|
8.2
nM
|
|
Inhibition of matrilysin (Matrix metalloprotease-7)
|
Homo sapiens
|
54.0
nM
|
|
Inhibition of Matrix metalloprotease-2
|
Homo sapiens
|
0.5
nM
|
|
50 percent inhibition of human Matrix metalloprotease-2 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
|
None
|
0.3
nM
|
|
Inhibitory activity against matrix metalloprotease-2 (MMP2)
|
None
|
0.5
nM
|
|
Inhibition of Matrix metalloprotease-2
|
Homo sapiens
|
0.05
nM
|
|
Inhibition of human matrix metalloprotease-2
|
None
|
0.08
nM
|
|
Inhibition of gelatinase-A (Matrix metalloprotease-2)
|
Homo sapiens
|
0.083
nM
|
|
Inhibition of matrix metalloprotease-2 (MMP-2).
|
Homo sapiens
|
0.083
nM
|
|
In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay
|
None
|
0.048
nM
|
|
In vitro inhibitory activity against matrix metalloprotease-3.
|
None
|
4.9
nM
|
|
Inhibition of Matrix metalloprotease-3
|
Homo sapiens
|
1.1
nM
|
|
Inhibitory activity against matrix metalloprotease-3 (MMP3)
|
None
|
1.1
nM
|
|
Inhibition of Matrix metalloprotease-3
|
Homo sapiens
|
0.27
nM
|
|
Inhibition of matrix metalloprotease-3 (MMP-3).
|
Homo sapiens
|
0.27
nM
|
|
Inhibition of Matrix metalloprotease-3 (MMP-3) in fluorimetric assay
|
None
|
3.5
nM
|
|
In vitro inhibitory activity against matrilysin (matrix metalloprotease-7).
|
None
|
91.0
nM
|
|
Inhibition of Matrix metalloprotease-7 (MMP-7) in fluorimetric assay
|
None
|
72.0
nM
|
|
Inhibition of neutrophil collagenase (Matrix metalloprotease-8)
|
Homo sapiens
|
0.4
nM
|
|
Inhibition of Matrix metalloprotease-8 (MMP-8) in fluorimetric assay
|
None
|
0.54
nM
|
|
Inhibition of gelatinase-B (Matrix metalloprotease-9)
|
Homo sapiens
|
0.4
nM
|
|
Inhibition of Matrix metalloprotease-9
|
Homo sapiens
|
0.2
nM
|
|
Inhibitory activity against matrix metalloprotease-9 (MMP9)
|
None
|
0.2
nM
|
|
In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay
|
None
|
0.048
nM
|
|
In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprotease-1).
|
None
|
4.9
nM
|
|
Inhibitory activity against MMP-1 (Matrix metalloprotease-1)
|
None
|
8.2
nM
|
|
Inhibition of Matrix metalloprotease-1
|
Homo sapiens
|
48.0
nM
|
|
50 percent inhibition of human Matrix metalloprotease-1 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
|
None
|
23.5
nM
|
|
Inhibitory activity against matrix metalloprotease-1 (MMP1)
|
None
|
48.0
nM
|
|
Inhibition of matrix metalloprotease-1 (MMP-1).
|
Homo sapiens
|
8.2
nM
|
|
Inhibition of human matrix metalloprotease-1
|
Homo sapiens
|
8.2
nM
|
|
In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay
|
None
|
5.7
nM
|
|
In vitro inhibitory activity against collagenase-3 (matrix metalloprotease-13).
|
None
|
0.4
nM
|
|
Inhibition of Matrix metalloprotease-13
|
Homo sapiens
|
1.5
nM
|
|
50 percent inhibition of human Matrix metalloprotease-13 by the cleavage of fluorogenic peptide MCA-Pro-Leu-Gly-Leu-Dpa-ala-Arg-NH2
|
None
|
0.5
nM
|
|
Inhibitory activity against matrix metalloprotease-13 (MMP13)
|
None
|
1.5
nM
|
|
Inhibition of collagenase (Matrix metalloprotease-13)
|
Homo sapiens
|
0.038
nM
|
|
Inhibition of matrix metalloprotease-13 (MMP-13).
|
Homo sapiens
|
0.038
nM
|
|
Inhibition of Matrix metalloprotease-13 (MMP-13) in fluorimetric assay
|
None
|
0.2
nM
|
|
In vitro inhibitory activity against gelatinase-A (matrix metalloprotease-2).
|
None
|
0.4
nM
|
|
Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.
|
None
|
5.5
nM
|
|
Inhibition of human matrix metalloprotease-1
|
Homo sapiens
|
8.2
nM
|
|
Inhibition of human matrix metalloprotease-2
|
Homo sapiens
|
0.09
nM
|
|
Inhibition of human matrix metalloprotease-3
|
Homo sapiens
|
0.23
nM
|
|
Inhibition of human matrix metalloprotease-7
|
Homo sapiens
|
54.0
nM
|
|
Inhibition of human matrix metalloprotease-9
|
Homo sapiens
|
0.26
nM
|
|
Inhibition of human matrix metalloprotease-14
|
Homo sapiens
|
0.3
nM
|
|
Inhibition of TACE
|
None
|
22.0
nM
|
|
Inhibition of recombinant human MMP2 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every mins for 20 min by colorimetric assay
|
Homo sapiens
|
1.8
nM
|
|
Inhibition of recombinant human MMP9 using thiopeptide as substrate preincubated for 30 mins followed by substrate addition and measured every min for 20 mins by colorimetric assay
|
Homo sapiens
|
3.3
nM
|
|