PLECONARIL


InChI Key	KQOXLKOJHVFTRN-UHFFFAOYSA-N
Smiles	Cc1cc(CCCOc2c(C)cc(-c3noc(C(F)(F)F)n3)cc2C)on1
InChI	InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3

Mechanism of Action	Action	Reference
VP1 capsid protein disrupting agent	DISRUPTING AGENT	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Cysteine protease Cysteine protease PAC clan Cysteine protease C3A subfamily	58	-	-	-	-
Structural protein	4-490	-	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I Nuclear hormone receptor subfamily 1 group I member 2	251.19	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Coxsackievirus B5	5	-	-	-	-
Enterovirus	136	-	-	-	-
Homo sapiens	251.19	-	-	-	-
Human coxsackievirus A9	33	-	-	-	-
Human coxsackievirus B1	130	-	-	-	-
Human coxsackievirus B3	2	1-410	-	-	-
Human coxsackievirus B5	5-8	-	-	-	-
Human enterovirus B	5	-	-	-	-
Human poliovirus 3	84-510	-	-	-	-
Human rhinovirus 14	177-310	-	-	-	-
Human rhinovirus 15	166	-	-	-	-
Human rhinovirus 16	570	-	-	-	-
Human rhinovirus 2	7-40	-	-	-	100
Human rhinovirus 29	26	-	-	-	-
Human rhinovirus 39	44	-	-	-	-
Human rhinovirus 41	655	-	-	-	-
Human rhinovirus 63	85	-	-	-	-
Human rhinovirus 70	167-578	-	-	-	-
Human rhinovirus 85	883	-	-	-	-
Human rhinovirus 86	89	-	-	-	-
Human rhinovirus 89	75	-	-	-	-
Human rhinovirus 9	83	-	-	-	-
Human rhinovirus A16	350	-	-	-	-
Human rhinovirus A2	15	40	-	-	-
Human rhinovirus A21	73-83	-	-	-	-
Human rhinovirus A39	100	-	-	-	-
Human rhinovirus A59	471	-	-	-	-
Human rhinovirus A71	9.4-13	-	-	-	-
Human rhinovirus A8	490	-	-	-	-
Human rhinovirus A85	11	-	-	-	-
Human rhinovirus A89	4	-	-	-	-
Human rhinovirus B	58	-	-	-	-
Human rhinovirus B14	30-300	70	-	-	-
Rhinovirus A	15	-	-	-	-
Rhinovirus B	200	-	-	-	-

CONTENTS