PHENFORMIN

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Search structure


Synonyms	Phenformin
Status
Molecule Category	Free-form
ATC	A10BA01
UNII	DD5K7529CE
EPA CompTox	DTXSID1023449

Structure


InChI Key	ICFJFFQQTFMIBG-UHFFFAOYSA-N
Smiles	N=C(N)NC(=N)NCCc1ccccc1
InChI	InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C10H15N5
Molecular Weight	205.26
AlogP	0.24
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	5.0
Number of Rotational Bond	3.0
Polar Surface Area	97.78
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-2.3-34.5

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	-2.3-34.5
Mus musculus	-	-	-	-	21-21
Plasmodium falciparum	-	0	-	-	-
Rattus norvegicus	-	-	-	-	0-81

Cross References

Resources	Reference
ChEBI	8064
ChEMBL	CHEMBL170988
DrugBank	DB00914
DrugCentral	2126
FDA SRS	DD5K7529CE
Human Metabolome Database	HMDB0015050
KEGG	C07673
PDB	8CV
PharmGKB	PA1000
PubChem	8249
SureChEMBL	SCHEMBL8424
ZINC	ZINC000005851063

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025