|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
-3.79
%
|
|
Title : Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection
Year : 2020
Authors : Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek
Abstract : To identify possible candidates for progression towards clinical studies against SARS-CoV-2, we screened a well-defined collection of 5632 compounds including 3488 compounds which have undergone clinical investigations (marketed drugs, phases 1 -3, and withdrawn) across 600 indications. Compounds were screened for their inhibition of viral induced cytotoxicity using the human epithelial colorectal adenocarcinoma cell line Caco-2 and a SARS-CoV-2 isolate. The primary screen of 5632 compounds gave 271 hits. A total of 64 compounds with IC50 <20 µM were identified, including 19 compounds with IC50 < 1 µM. Of this confirmed hit population, 90% have not yet been previously reported as active against SARS-CoV-2 in-vitro cell assays. Some 37 of the actives are launched drugs, 19 are in phases 1-3 and 10 pre-clinical. Several inhibitors were associated with modulation of host pathways including kinase signaling P53 activation, ubiquitin pathways and PDE activity modulation, with long chain acyl transferases were effective viral inhibitors.
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
19.32
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
12.53
%
|
|
Title : Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
Year : 2020
Authors : Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani
Abstract : Compound repurposing is an important strategy being pursued in the identification of effective treatment against the SARS-CoV-2 infection and COVID-19 disease. In this regard, SARS-CoV-2 main protease (M-Pro), also termed 3CL-Pro, is an attractive drug target as it plays a central role in viral replication by processing the viral polyprotein into 11 non-structural proteins. We report the results of a screening campaign involving ca 8.7 K compounds containing marketed drugs, clinical and preclinical candidates, and chemicals regarded as safe in humans. We confirmed previously reported inhibitors of 3CL-Pro, but we have also identified 68 compounds with IC50 lower than 1 uM and 127 compounds with IC50 lower than 5 uM. Profiling showed 67% of confirmed hits were selective (> 5 fold) against other Cys- and Ser- proteases (Chymotrypsin and Cathepsin-L) and MERS 3CL-Pro. Selected compounds were also analysed in their binding characteristics.
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.2
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.06
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.2
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.06
%
|
|
Title : Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort
Year : 2020
Authors : Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen
Abstract : Worldwide, there are intensive efforts to identify repurposed drugs as potential therapies against SARS-CoV-2 infection and the associated COVID-19 disease. To date, the anti-inflammatory drug dexamethasone and (to a lesser extent) the RNA-polymerase inhibitor remdesivir have been shown to be effective in reducing mortality and patient time to recovery, respectively, in patients. Here, we report the results of a phenotypic screening campaign within an EU-funded project (H2020-EXSCALATE4COV) aimed at extending the repertoire of anti-COVID therapeutics through repurposing of available compounds and highlighting compounds with new mechanisms of action against viral infection. We screened 8702 molecules from different repurposing libraries, to reveal 110 compounds with an anti-cytopathic IC50 < 20 µM. From this group, 18 with a safety index greater than 2 are also marketed drugs, making them suitable for further study as potential therapies against COVID-19. Our result supports the idea that a systematic approach to repurposing is a valid strategy to accelerate the necessary drug discovery process.
|
GPCRScan assay: inhibition of 5-HT1A
|
Homo sapiens
|
-22.74
%
|
|
|
GPCRScan assay: inhibition of 5-HT1B
|
Homo sapiens
|
-11.25
%
|
|
|
GPCRScan assay: inhibition of 5-HT1D
|
Homo sapiens
|
-24.02
%
|
|
|
GPCRScan assay: inhibition of 5-HT1E
|
Homo sapiens
|
10.97
%
|
|
|
GPCRScan assay: inhibition of 5-HT2A
|
Homo sapiens
|
6.25
%
|
|
|
GPCRScan assay: inhibition of 5-HT2B
|
Homo sapiens
|
-0.11
%
|
|
|
GPCRScan assay: inhibition of 5-HT2C
|
Homo sapiens
|
12.35
%
|
|
|
GPCRScan assay: inhibition of 5-HT3
|
Homo sapiens
|
0.08
%
|
|
|
GPCRScan assay: inhibition of 5-HT5A
|
Homo sapiens
|
-8.97
%
|
|
|
GPCRScan assay: inhibition of 5-HT6
|
Homo sapiens
|
-6.47
%
|
|
|
GPCRScan assay: inhibition of 5-HT7A
|
Homo sapiens
|
-9.26
%
|
|
|
GPCRScan assay: inhibition of D1
|
Homo sapiens
|
-26.64
%
|
|
|
GPCRScan assay: inhibition of D2
|
Homo sapiens
|
-23.45
%
|
|
|
GPCRScan assay: inhibition of D3
|
Homo sapiens
|
32.96
%
|
|
|
GPCRScan assay: inhibition of D4
|
Homo sapiens
|
8.76
%
|
|
|
GPCRScan assay: inhibition of D5
|
Homo sapiens
|
-2.51
%
|
|
|
GPCRScan assay: inhibition of SERT
|
Homo sapiens
|
-6.83
%
|
|
|
GPCRScan assay: inhibition of NET
|
Homo sapiens
|
11.01
%
|
|
|
GPCRScan assay: inhibition of DAT
|
Homo sapiens
|
-14.46
%
|
|
|
GPCRScan assay: inhibition of MOR
|
Homo sapiens
|
1.07
%
|
|
|
GPCRScan assay: inhibition of DOR
|
Homo sapiens
|
5.07
%
|
|
|
GPCRScan assay: inhibition of KOR
|
Homo sapiens
|
16.41
%
|
|
|
GPCRScan assay: inhibition of GABAA
|
Rattus
|
-1.97
%
|
|
|
GPCRScan assay: inhibition of H1
|
Homo sapiens
|
-11.53
%
|
|
|
GPCRScan assay: inhibition of H2
|
Homo sapiens
|
3.0
%
|
|
|
GPCRScan assay: inhibition of H3
|
Homo sapiens
|
-15.34
%
|
|
|
GPCRScan assay: inhibition of H4
|
Homo sapiens
|
-17.71
%
|
|
|
GPCRScan assay: inhibition of Alpha1A
|
Homo sapiens
|
2.52
%
|
|
|
GPCRScan assay: inhibition of Alpha1B
|
Homo sapiens
|
-11.36
%
|
|
|
GPCRScan assay: inhibition of Alpha2A
|
Homo sapiens
|
21.8
%
|
|
|
GPCRScan assay: inhibition of Alpha2B
|
Homo sapiens
|
9.24
%
|
|
|
GPCRScan assay: inhibition of Alpha2C
|
Homo sapiens
|
9.72
%
|
|
|
GPCRScan assay: inhibition of Beta1
|
Homo sapiens
|
-12.18
%
|
|
|
GPCRScan assay: inhibition of Beta2
|
Homo sapiens
|
-17.45
%
|
|
|
GPCRScan assay: inhibition of M1
|
Homo sapiens
|
-0.03
%
|
|
|
GPCRScan assay: inhibition of M2
|
Homo sapiens
|
16.71
%
|
|
|
GPCRScan assay: inhibition of M3
|
Homo sapiens
|
19.22
%
|
|
|
GPCRScan assay: inhibition of M4
|
Homo sapiens
|
-18.57
%
|
|
|
GPCRScan assay: inhibition of M5
|
Homo sapiens
|
-7.44
%
|
|
|
GPCRScan assay: inhibition of Beta3
|
Homo sapiens
|
-19.86
%
|
|
|
GPCRScan assay: inhibition of GABAA/BZP
|
Rattus
|
18.7
%
|
|
|
GPCRScan assay: inhibition of GABA/PBR
|
Rattus
|
-30.46
%
|
|
|
GPCRScan assay: inhibition of Alpha1D
|
Homo sapiens
|
-3.76
%
|
|
|
GPCRScan assay: inhibition of Sigma 2
|
Homo sapiens
|
-1.29
%
|
|
|
GPCRScan assay: inhibition of Sigma 1
|
Homo sapiens
|
21.07
%
|
|
|
Inhibition of binding to PTGER2
|
Homo sapiens
|
5.0
nM
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Binding assay (PTGFR)
|
Homo sapiens
|
10.0
µM
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Binding assay (PTGIR)
|
Homo sapiens
|
10.0
µM
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Binding assay (TBXA2R)
|
Homo sapiens
|
10.0
µM
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Binding assay (LTB4R )
|
Homo sapiens
|
4.8
µM
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT transporter (h) CEREP ligand profiling
|
Homo sapiens
|
-8.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT1A (h) CEREP ligand profiling
|
Homo sapiens
|
6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT1B CEREP ligand profiling
|
Homo sapiens
|
-7.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT1D CEREP ligand profiling
|
None
|
-10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT2A (h) CEREP ligand profiling
|
None
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT2A (h) (agonist site) CEREP ligand profiling
|
Homo sapiens
|
-15.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT2B (h) (agonist site/DOI) CEREP ligand profiling
|
Homo sapiens
|
13.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT2C (h) CEREP ligand profiling
|
Homo sapiens
|
8.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT2C (h) (agonist site) CEREP ligand profiling
|
Homo sapiens
|
-6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT3 (h) CEREP ligand profiling
|
Homo sapiens
|
-6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT4e (h) CEREP ligand profiling
|
Homo sapiens
|
-14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT6 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
5-HT7 (h) CEREP ligand profiling
|
Homo sapiens
|
-2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
A1 (h) CEREP ligand profiling
|
Homo sapiens
|
-2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
A2A (h) CEREP ligand profiling
|
Homo sapiens
|
-9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
A3 (h) CEREP ligand profiling
|
Homo sapiens
|
-10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Abl kinase (h) CEREP ligand profiling
|
Homo sapiens
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ACE (h) CEREP ligand profiling
|
Homo sapiens
|
14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Acetylcholinesterase (h) CEREP ligand profiling
|
Homo sapiens
|
45.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
alpha 1 (non- selective) CEREP ligand profiling
|
None
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
alpha 2A (h) CEREP ligand profiling
|
Homo sapiens
|
26.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
alpha 2B (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
alpha 2C (h) CEREP ligand profiling
|
Homo sapiens
|
4.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
AMPA CEREP ligand profiling
|
None
|
-13.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Androgen (h) (AR) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
AT1 (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ATPase (Na+/K+) CEREP ligand profiling
|
Homo sapiens
|
5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
beta 1 (h) CEREP ligand profiling
|
Homo sapiens
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
beta 2 (h) CEREP ligand profiling
|
Homo sapiens
|
-4.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
beta 3 (h) CEREP ligand profiling
|
Homo sapiens
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Ca2+ channel (L, DHP site) CEREP ligand profiling
|
Homo sapiens
|
-3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Ca2+ channel (L, diltiazem site) CEREP ligand profiling
|
Homo sapiens
|
6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Ca2+ channel (L, verapamil site) CEREP ligand profiling
|
Homo sapiens
|
-5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Ca2+ channel (N) CEREP ligand profiling
|
Homo sapiens
|
-7.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CaMK2alpha (h) CEREP ligand profiling
|
Homo sapiens
|
5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Carbonic anhydrase II (h) CEREP ligand profiling
|
Homo sapiens
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Caspase-3 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CB1 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CB2 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CCKA (h) (CCK1) CEREP ligand profiling
|
Homo sapiens
|
29.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CCKB (h) (CCK2) CEREP ligand profiling
|
Homo sapiens
|
-8.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Choline transporter (h) (CHT1) CEREP ligand profiling
|
Homo sapiens
|
4.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Cl- channel CEREP ligand profiling
|
None
|
19.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
COX1 (h) CEREP ligand profiling
|
Homo sapiens
|
-25.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
COX2 (h) CEREP ligand profiling
|
Homo sapiens
|
2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CXCR4 (h) CEREP ligand profiling
|
Homo sapiens
|
4.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CYP2C19 inhibition CEREP ligand profiling
|
None
|
5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CYP2C9 inhibition CEREP ligand profiling
|
None
|
41.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CYP2D6 inhibition CEREP ligand profiling
|
None
|
18.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
CYP3A4 inhibition CEREP ligand profiling
|
None
|
17.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
D1 (h) CEREP ligand profiling
|
Homo sapiens
|
5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
D2S (h) CEREP ligand profiling
|
Homo sapiens
|
-2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
D2S (h) (agonist site) CEREP ligand profiling
|
Homo sapiens
|
-6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
D3 (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
D4.4 (h) CEREP ligand profiling
|
Homo sapiens
|
-8.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
DA transporter (h) CEREP ligand profiling
|
Homo sapiens
|
11.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
delta 2 (h) (DOP) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ETA (h) CEREP ligand profiling
|
Homo sapiens
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ETB (h) CEREP ligand profiling
|
Homo sapiens
|
-1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
FLT-1 kinase (h) (VEGFR1) CEREP ligand profiling
|
Homo sapiens
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
GABAA BZD (central) CEREP ligand profiling
|
None
|
10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
GABA transporter CEREP ligand profiling
|
None
|
14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
GABAA CEREP ligand profiling
|
None
|
16.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
GABAB (1b) (h) CEREP ligand profiling
|
Homo sapiens
|
-21.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Ghrelin (h) (GHS) CEREP ligand profiling
|
Homo sapiens
|
-6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
GR (h) CEREP ligand profiling
|
Homo sapiens
|
-1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Glycine (strychnine-insensitive) CEREP ligand profiling
|
None
|
11.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
H1 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
H2 (h) CEREP ligand profiling
|
Homo sapiens
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
H3 (h) CEREP ligand profiling
|
Homo sapiens
|
10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
H4 (h) CEREP ligand profiling
|
Homo sapiens
|
-4.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
I1 CEREP ligand profiling
|
None
|
-14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Kainate CEREP ligand profiling
|
None
|
-15.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
kappa (KOP) CEREP ligand profiling
|
Homo sapiens
|
46.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
LTB4 (h) (BLT1) CEREP ligand profiling
|
Homo sapiens
|
51.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
LTD4 (h) (CysLT1) CEREP ligand profiling
|
Homo sapiens
|
2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Lyn kinase (h) CEREP ligand profiling
|
Homo sapiens
|
2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
M1 (h) CEREP ligand profiling
|
Homo sapiens
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
M2 (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
M3 (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
M4 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
M5 (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
MAO-A CEREP ligand profiling
|
None
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
MC1 CEREP ligand profiling
|
None
|
6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
MC3 (h) CEREP ligand profiling
|
Homo sapiens
|
-11.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
MC4 (h) CEREP ligand profiling
|
Homo sapiens
|
8.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
MCH1 (h) CEREP ligand profiling
|
Homo sapiens
|
-13.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ML1 CEREP ligand profiling
|
None
|
-3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ML2 (MT3) CEREP ligand profiling
|
None
|
93.0
%
|
|
ML2 (MT3) CEREP ligand profiling
|
None
|
530.0
nM
|
|
ML2 (MT3) CEREP ligand profiling
|
None
|
520.0
nM
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
MMP-9 (h) CEREP ligand profiling
|
Homo sapiens
|
10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Motilin (h) CEREP ligand profiling
|
Homo sapiens
|
-5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
mu (h) (MOP) (agonist site) CEREP ligand profiling
|
Homo sapiens
|
-7.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
N (muscle-type) (h) CEREP ligand profiling
|
Homo sapiens
|
-10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
N (neuronal) (alpha -BGTX-insensitive) (alpha 4 beta 2) CEREP ligand profiling
|
None
|
-10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Na+ channel (site 2) CEREP ligand profiling
|
None
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
NE transporter (h) CEREP ligand profiling
|
Homo sapiens
|
-2.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
NK1 (h) CEREP ligand profiling
|
Homo sapiens
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
NK2 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
NMDA CEREP ligand profiling
|
None
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
p38 alpha kinase (h) CEREP ligand profiling
|
Homo sapiens
|
-1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PCP CEREP ligand profiling
|
None
|
-6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PDE11 (h) CEREP ligand profiling
|
Homo sapiens
|
14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PDE2 (h) CEREP ligand profiling
|
Homo sapiens
|
5.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PDE3 (h) CEREP ligand profiling
|
Homo sapiens
|
78.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PDE4 (h) CEREP ligand profiling
|
Homo sapiens
|
8.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PDE5 (h) CEREP ligand profiling
|
Homo sapiens
|
6.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PDE6 CEREP ligand profiling
|
None
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
PPAR gamma (h) CEREP ligand profiling
|
Homo sapiens
|
14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Rolipram CEREP ligand profiling
|
None
|
3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
sigma (non-selective) CEREP ligand profiling
|
None
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
SK+Ca channel CEREP ligand profiling
|
None
|
-1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
sst4 (h) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
TH CEREP ligand profiling
|
None
|
-10.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
TNF-alpha (h) CEREP ligand profiling
|
Homo sapiens
|
-1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
TXA2/P GH2 (h)(TP) CEREP ligand profiling
|
Homo sapiens
|
0.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
UT1 (h) CEREP ligand profiling
|
Homo sapiens
|
14.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
V1a (h) CEREP ligand profiling
|
Homo sapiens
|
-3.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
V2 (h) CEREP ligand profiling
|
Homo sapiens
|
-1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
VIP1 (h) (VPAC1) CEREP ligand profiling
|
Homo sapiens
|
-13.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
Y1 (h) CEREP ligand profiling
|
Homo sapiens
|
1.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
|
ZAP70 kinase (h) CEREP ligand profiling
|
Homo sapiens
|
9.0
%
|
|
Title : Data for DCP probe PF-04418948
Year : 2021
Authors : SGC Frankfurt
Abstract : SGC Frankfurt donated chemical probe project: PF-04418948 was donated by Pfizer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/PF-04418948. Control: PF-04475866. References: 1. af Forselles, K J, J Root, T Clarke, D Davey, K Aughton, K Dack, and N Pullen. 2011. ‘In Vitro and in Vivo Characterization of PF-04418948, a Novel, Potent and Selective Prostaglandin EP₂ Receptor Antagonist’. British Journal of Pharmacology 164(7):1847–56. PMID: 21595651.
