OXYMORPHONE


Synonyms	14-hydroxydihydromorphinone 7,8-dihydro-14-hydroxymorphinone Dihydroxymorphinone IDS-NO-003 NIH 10323 NSC-19045 Numorphan Opana Oxycodone hydrochloride impurity, oxymorphone- Oxymorphone Oxymorphone cii
Status
Molecule Category	Free-form
ATC	N02AA11
UNII	9VXA968E0C
EPA CompTox	DTXSID5023409


InChI Key	UQCNKQCJZOAFTQ-ISWURRPUSA-N
Smiles	CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
InChI	InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1

Property Name	Value
Molecular Formula	C17H19NO4
Molecular Weight	301.34
AlogP	0.75
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Polar Surface Area	70.0
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	22.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Opioid receptor	1-7.8	0.013-630	-	0.54-730	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	1.4-630	-	0.54-725	-
Homo sapiens	7.8	-	-	1.79-70	-
Mus musculus	-	77	-	4.677-724.44	-
Rattus norvegicus	1	-	-	0.97-80.5	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	7865
ChEMBL	CHEMBL963
DrugBank	DB01192
DrugCentral	2034
FDA SRS	9VXA968E0C
Human Metabolome Database	HMDB0015323
Guide to Pharmacology	7094
KEGG	C08019
PubChem	5284604
SureChEMBL	SCHEMBL3571
ZINC	ZINC000003875483

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

OXYMORPHONE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

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