MOXIFLOXACIN


Synonyms	Avelox Avelox i.v. Avelox iv Moxifloxacin Vigamox Zimoxin
Status
Molecule Category	Free-form
ATC	J01MA14 S01AE07
UNII	U188XYD42P
EPA CompTox	DTXSID3048491


InChI Key	FABPRXSRWADJSP-MEDUHNTESA-N
Smiles	COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12
InChI	InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1

Property Name	Value
Molecular Formula	C21H24FN3O4
Molecular Weight	401.44
AlogP	2.37
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	83.8
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	29.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Isomerase	-	300-800	-	-	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	-	-	-	10-42.3

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Escherichia coli	-	300	-	-	-
Homo sapiens	-	-	-	-	10-42.3
Mus musculus	-	-	-	-	1.26
Mycobacterium avium subsp. avium	-	190	-	-	-
Mycobacterium bovis BCG	-	30	-	-	-
Mycobacterium marinum	-	140	-	-	-
Mycobacterium tuberculosis	-	250	-	-	-
Mycobacterium tuberculosis H37Rv	-	-	-	-	100
Staphylococcus aureus	-	800-800	-	-	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Countries
India

Resources	Reference
ChEBI	63611
ChEMBL	CHEMBL32
DrugBank	DB00218
DrugCentral	1854
FDA SRS	U188XYD42P
Human Metabolome Database	HMDB0014363
Guide to Pharmacology	10915
PDB	MFX
PharmGKB	PA450555
PubChem	152946
SureChEMBL	SCHEMBL24007
ZINC	ZINC000003826253

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

MOXIFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

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Environmental Exposure

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