MOTESANIB


InChI Key	RAHBGWKEPAQNFF-UHFFFAOYSA-N
Smiles	CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21
InChI	InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)

Mechanism of Action	Action	Reference
Platelet-derived growth factor receptor inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase DMPK family AGC protein kinase CRIK subfamily	-	-	300-300	-	-
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE11 family	-	-	200	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family	-	-	670-910	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase DDR family	-	-	260-260	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family	-	-	15-960	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Eph family	-	-	490-490	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	-	1.3-410	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family	-	66-90	14-20	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	-	99-360	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	2-6	9.7-26	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase HH498 subfamily	-	-	220-220	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase MLK family TKL protein kinase MLK subfamily	-	-	8-8	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RAF family	-	-	280-880	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	2-90	3.2-880	-	-


Protein: Tyrosine-protein kinase receptor RET Description: Proto-oncogene tyrosine-protein kinase receptor Ret Organism : Homo sapiens P07949 ENSG00000165731













Protein: Platelet-derived growth factor receptor Description: Platelet-derived growth factor receptor beta Organism : Homo sapiens P09619 ENSG00000113721











Protein: Stem cell growth factor receptor Description: Mast/stem cell growth factor receptor Kit Organism : Homo sapiens P10721 ENSG00000157404












Protein: Platelet-derived growth factor receptor Description: Platelet-derived growth factor receptor alpha Organism : Homo sapiens P16234 ENSG00000134853












Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 1 Organism : Homo sapiens P17948 ENSG00000102755











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 3 Organism : Homo sapiens P35916 ENSG00000037280











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 2 Organism : Homo sapiens P35968 ENSG00000128052

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