MK-3577

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Synonyms
Status
Molecule Category Free-form
UNII 03TW1410NL

Structure

InChI Key FYRJJCYFYLLOSC-LXFBAYGMSA-N
Smiles CCC[C@H](c1ccc(C(=O)NCCC(=O)O)cc1)[C@H](c1ccc(Cl)cc1)c1c[nH]c2c(F)cc(C)cc12
InChI
InChI=1S/C30H30ClFN2O3/c1-3-4-23(19-5-7-21(8-6-19)30(37)33-14-13-27(35)36)28(20-9-11-22(31)12-10-20)25-17-34-29-24(25)15-18(2)16-26(29)32/h5-12,15-17,23,28,34H,3-4,13-14H2,1-2H3,(H,33,37)(H,35,36)/t23-,28+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C30H30ClFN2O3
Molecular Weight 521.03
AlogP 7.19
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 10.0
Polar Surface Area 82.19
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 37.0

Pharmacology

Mechanism of Action Action Reference
Glucagon receptor antagonist ANTAGONIST PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Glucagon-like receptor Glucagon receptor
- - - 4 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- - - 4 -

Target Conservation

Protein: Glucagon receptor
Description: Glucagon receptor
Organism : Homo sapiens
P47871 ENSG00000215644

Cross References

Resources Reference
ChEMBL CHEMBL1933350
DrugBank DB14957
FDA SRS 03TW1410NL
PubChem 46240797
SureChEMBL SCHEMBL826813
ZINC ZINC000073389642
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