Synonyms | |
Status | |
Molecule Category | Free-form |
UNII | 51HZG6MP1K |
EPA CompTox | DTXSID3048948 |
InChI Key | ULDXWLCXEDXJGE-UHFFFAOYSA-N | |
---|---|---|
Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C25H21N5O | |
Molecular Weight | 407.48 | |
AlogP | 4.24 | |
Hydrogen Bond Acceptor | 5.0 | |
Hydrogen Bond Donor | 2.0 | |
Number of Rotational Bond | 3.0 | |
Polar Surface Area | 89.07 | |
Molecular species | BASE | |
Aromatic Rings | 5.0 | |
Heavy Atoms | 31.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
Serine/threonine-protein kinase AKT inhibitor | INHIBITOR | PubMed Other |
Protein: Serine/threonine-protein kinase AKT Description: RAC-alpha serine/threonine-protein kinase Organism : Homo sapiens P31749 ENSG00000142208 |
||||
Protein: Serine/threonine-protein kinase AKT Description: RAC-beta serine/threonine-protein kinase Organism : Homo sapiens P31751 ENSG00000105221 |
||||
Protein: Serine/threonine-protein kinase AKT Description: RAC-gamma serine/threonine-protein kinase Organism : Homo sapiens Q9Y243 ENSG00000117020 |
||||
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | ||
---|---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase AKT family
|
- | 8-10 | - | - | - |
Resources | Reference | |
---|---|---|
ChEBI | 67271 | |
ChEMBL | CHEMBL1079175 | |
FDA SRS | 51HZG6MP1K | |
Guide to Pharmacology | 7945 | |
PubChem | 67254077 | |
SureChEMBL | SCHEMBL530721 | |
ZINC | ZINC000036382821 |