MARIMASTAT


Synonyms	BB 2516 BB-2516 GI 5712 GI-5712 KB-R 8898 Marimastat NSC-719333 TA 2516 TA-2516
Status
Molecule Category	Free-form
UNII	D5EQV23TDS
EPA CompTox	DTXSID20165524


InChI Key	OCSMOTCMPXTDND-OUAUKWLOSA-N
Smiles	CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
InChI	InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1

Mechanism of Action	Action	Reference
Matrix metalloproteinase 12 inhibitor	INHIBITOR	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Metallo protease Metallo protease MAM clan Metallo protease M10A subfamily	-	0.41-200	-	0.6-84	-
Enzyme Protease Metallo protease Metallo protease MAM clan Metallo protease M12B subfamily	-	3.8-3.8	-	0.4-6.3	30

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.43-25	-	0.4-84	30
Mus musculus	-	-	-	-	40
Rattus norvegicus	-	-	-	-	11-69


Protein: Matrix metalloproteinase-1 Description: Interstitial collagenase Organism : Homo sapiens P03956 ENSG00000196611











Protein: Matrix metalloproteinase-2 Description: 72 kDa type IV collagenase Organism : Homo sapiens P08253 ENSG00000087245












Protein: Matrix metalloproteinase 3 Description: Stromelysin-1 Organism : Homo sapiens P08254 ENSG00000149968







Protein: Matrix metalloproteinase 7 Description: Matrilysin Organism : Homo sapiens P09237 ENSG00000137673











Protein: Matrix metalloproteinase 9 Description: Matrix metalloproteinase-9 Organism : Homo sapiens P14780 ENSG00000100985











Protein: Matrix metalloproteinase 12 Description: Macrophage metalloelastase Organism : Homo sapiens P39900 ENSG00000262406

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