LUTEOLIN

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
UNII KUX1ZNC9J2
EPA CompTox DTXSID4074988

Structure

InChI Key IQPNAANSBPBGFQ-UHFFFAOYSA-N
Smiles O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
InChI
InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H10O6
Molecular Weight 286.24
AlogP 2.28
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 1.0
Polar Surface Area 111.13
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 21.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 1 Cytochrome P450 family 1A Cytochrome P450 1A1
- - - 890 -
Enzyme Cytochrome P450 Cytochrome P450 family 1 Cytochrome P450 family 1B Cytochrome P450 1B1
- 79-360 - 56 -
Enzyme Hydrolase
- 450 - - 0.42-99.89
Enzyme Isomerase
- 660 - - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKC family AGC protein kinase PKC alpha subfamily
- - - - 70
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKC family AGC protein kinase PKC delta subfamily
- - - - 70
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKC family AGC protein kinase PKC eta subfamily
- - - - 70
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKC family AGC protein kinase PKC iota subfamily
- - - - 70
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKC family
- - - - 70
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PDHK subfamily
- - - - 31.12
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase MAPKAPK family CAMK protein kinase MNK subfamily
- 179-579 - - 100-100
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase GSK family
- 800 - - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase CK2 family
- 500 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 830 - - -
Enzyme Kinase Protein kinase regulatory subunit
- 500 - - -
Enzyme Lyase
- - - 4.7-293 -
Enzyme Oxidoreductase
- 550-754 - - 6.4-80
Enzyme Phosphatase Protein Phosphatase Tyrosine protein phosphatase
- - - - 19.8-40.75
Enzyme Protease Metallo protease Metallo protease MAM clan Metallo protease M10A subfamily
- 980 - - -
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily
- - - - 28.7
Enzyme Protease Serine protease Serine protease SC clan Serine protease S9B subfamily
- 120 - - -
Enzyme
- 550-754 - 4.7-293 6.4-80
Ion channel Other ion channel Miscellaneous ion channel Bcl-2 family
- - - - 46-49
Membrane receptor
- - - - 86.5
Secreted protein
- - 70 - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group H Nuclear hormone receptor subfamily 1 group H member 3
- - - - 41-64
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group H
- - - - 41-64
Unclassified protein
- - - - 32-84
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Agaricus bisporus
- - - - 6.4-33.5
Bos taurus
- 754 - - -
Electrophorus electricus
- - - - 13.58
Equus caballus
- - - - 0.42
Escherichia coli
- - - - 0
Homo sapiens
- 79-980 70 4.7-293 -4.47-100
Human immunodeficiency virus 1
- 450 - - -
Influenza A virus (A/California/07/2009(H1N1))
- 72 - - -
Mus musculus
- 210 - - -4.9-76.7
Plasmodium falciparum
- - - 800 -
Rattus norvegicus
- 660 - - 0-101.3
Saccharomyces cerevisiae
- - - - 99.6
Spodoptera exigua
- - - - 37.96-66.85
Xanthomonas oryzae pv. oryzae
- 810 - 440-990 -

Related Entries

Cross References

Resources Reference
ChEBI 15864
ChEMBL CHEMBL151
DrugBank DB15584
FDA SRS KUX1ZNC9J2
Human Metabolome Database HMDB0005800
Guide to Pharmacology 5215
KEGG C01514
PDB LU2
PubChem 5280445
SureChEMBL SCHEMBL20426
ZINC ZINC000018185774
CONTENTS