LUCITANIB

/static/temp/default.svg

Search structure


Synonyms	AL-3810 Al-3810 CO-3810 E-3810 Lucitanib S 80881 S-80881
Status
Molecule Category	Free-form
UNII	PP449XA4BH
EPA CompTox	DTXSID30147356

Structure


InChI Key	CUDVHEFYRIWYQD-UHFFFAOYSA-N
Smiles	CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12
InChI	InChI=1S/C26H25N3O4/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C26H25N3O4
Molecular Weight	443.5
AlogP	4.42
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	95.7
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	33.0

Pharmacology

Mechanism of Action	Action	Reference
Fibroblast growth factor receptor 1 inhibitor	INHIBITOR	PubMed PubMed Other

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	17.5-237.5	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	7-25	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	7-237.5	-	-	-

Target Conservation


Protein: Fibroblast growth factor receptor 1 Description: Fibroblast growth factor receptor 1 Organism : Homo sapiens P11362 ENSG00000077782












Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 1 Organism : Homo sapiens P17948 ENSG00000102755











Protein: Fibroblast growth factor receptor 2 Description: Fibroblast growth factor receptor 2 Organism : Homo sapiens P21802 ENSG00000066468












Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 3 Organism : Homo sapiens P35916 ENSG00000037280











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 2 Organism : Homo sapiens P35968 ENSG00000128052

Cross References

Resources	Reference
ChEBI	65209
ChEMBL	CHEMBL2220486
DrugBank	DB11845
FDA SRS	PP449XA4BH
Guide to Pharmacology	7649
PDB	3ZC
PharmGKB	PA166131607
PubChem	25031915
SureChEMBL	SCHEMBL381394
ZINC	ZINC000077024213

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025