LIOTHYRONINE


Synonyms	3,5,3'-triiodothyronine, l- Cyronine Cytomel Euthroid-0.5 Euthroid-1 Euthroid-2 Euthroid-3 Levothyroxine sodium related compound liothyronine Liothyronine NSC-80203 Rathyronine Rathyronine, (s)- Tertroxin Thyrolar-0.25 Thyrolar-0.5
Status
Molecule Category	Free-form
UNII	06LU7C9H1V
EPA CompTox	DTXSID8023216


InChI Key	AUYYCJSJGJYCDS-LBPRGKRZSA-N
Smiles	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O
InChI	InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

Property Name	Value
Molecular Formula	C15H12I3NO4
Molecular Weight	650.98
AlogP	3.95
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	92.78
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	23.0

Mechanism of Action	Action	Reference
Thyroid hormone receptor agonist	AGONIST	DailyMed Wikipedia Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	1.2-6.2	-	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group A Nuclear hormone receptor subfamily 1 group A member 1	0.41-10	0.24-3.2	0.058-0.17	0.22-2.33	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group A Nuclear hormone receptor subfamily 1 group A member 2	2-15	0.257-500	0.081-0.14	0.08-2.29	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3	-	-	710	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	-	-	-	-	24

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	0.41-30	0.24-3.2	0.058-710	0.33-2.33	-
Rattus norvegicus	-	0.034-1.1	-	0.018	6
Xenopus laevis	0.5	-	-	-	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	18258
ChEMBL	CHEMBL1544
DrugBank	DB00279
DrugCentral	1585
FDA SRS	06LU7C9H1V
Human Metabolome Database	HMDB0000265
Guide to Pharmacology	2634
KEGG	C02465
PDB	T3
PharmGKB	PA164778866
PubChem	5920
SureChEMBL	SCHEMBL8300
ZINC	ZINC000003830999

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

LIOTHYRONINE

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Physicochemical Descriptors

Pharmacology

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