EcoDrugPlus


Synonyms	(1s,2r)-milnacipran F 2695 F-2695 F2695 Fetzima Levomilnacipran Milnacipran, (1s,2r)-
Status
Molecule Category	Free-form
UNII	UGM0326TXX


InChI Key	GJJFMKBJSRMPLA-DZGCQCFKSA-N
Smiles	CCN(CC)C(=O)[C@@]1(c2ccccc2)C[C@H]1CN
InChI	InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1

Property Name	Value
Molecular Formula	C15H22N2O
Molecular Weight	246.35
AlogP	1.77
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	46.33
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	18.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor	-	-	-	-	53
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	40-320	-	8.5-8.5	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	40-320	-	-	-
Rattus norvegicus	-	-	-	8.5-8.5	-
Xenopus laevis	-	-	-	-	53

Resources	Reference
ChEBI	136040
ChEMBL	CHEMBL99946
DrugBank	DB08918
DrugCentral	4864
FDA SRS	UGM0326TXX
Guide to Pharmacology	7435
PubChem	6917779
SureChEMBL	SCHEMBL1414867
ZINC	ZINC000000000506

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

LEVOMILNACIPRAN

Structure

Physicochemical Descriptors

Pharmacology

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