LESOGABERAN

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Search structure


Synonyms	AZD-3355 AZD3355 Azd3355 Lesogaberan
Status
Molecule Category	Free-form
UNII	4D6Q6HGC7Z
EPA CompTox	DTXSID20188011

Structure


InChI Key	LJNUIEQATDYXJH-GSVOUGTGSA-N
Smiles	NC[C@@H](F)C[PH](=O)O
InChI	InChI=1S/C3H9FNO2P/c4-3(1-5)2-8(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C3H9FNO2P
Molecular Weight	141.08
AlogP	-0.25
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	63.32
Molecular species	ZWITTERION
Aromatic Rings	0.0
Heavy Atoms	8.0

Pharmacology

Mechanism of Action	Action	Reference
GABA-B receptor 1 agonist	AGONIST	PubMed Other

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	7.943-8.64	-	-	-	-
Rattus norvegicus	-	-	-	5.1	-

Target Conservation


Protein: GABA-B receptor 1 Description: Gamma-aminobutyric acid type B receptor subunit 1 Organism : Homo sapiens Q9UBS5 ENSG00000204681

Cross References

Resources	Reference
ChEMBL	CHEMBL448343
DrugBank	DB11920
FDA SRS	4D6Q6HGC7Z
Guide to Pharmacology	7705
PubChem	9833984
SureChEMBL	SCHEMBL349234
ZINC	ZINC000040829484

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025