ISOPROTERENOL

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Synonyms
Status
Molecule Category Free-form
UNII L628TT009W
EPA CompTox DTXSID4023175

Structure

InChI Key JWZZKOKVBUJMES-UHFFFAOYSA-N
Smiles CC(C)NCC(O)c1ccc(O)c(O)c1
InChI
InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H17NO3
Molecular Weight 211.26
AlogP 1.13
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 4.0
Polar Surface Area 72.72
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 15.0
Assay Description Organism Bioactivity Reference
Compound was evaluated for its binding affinity towards beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol None 600.0 nM
Compound was evaluated for beta adrenergic binding affinity towards Beta-1 adrenergic receptor of rat brain None 80.0 nM
Compound was evaluated for the inhibition of binding of [3H]dihydroalprenolol from beta-1 adrenergic receptor of rat cerebral cortical membranes None 670.0 nM
Tested for binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-CGP- 26505 as radioligand None 80.0 nM
Compound was evaluated for beta adrenergic binding affinity towards beta-2 receptor of bovine lung None 110.0 nM
Tested for binding affinity against beta-2 adrenergic receptor in bovine lung using [3H]DHA as radioligand None 110.0 nM
Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) None 330.0 nM
Evaluated for Beta adrenergic receptor agonistic property in isolated guinea pig atria Cavia porcellus 30.0 nM
Binding Affinity against human beta-2 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligand None 676.08 nM
Effective concentration against 125I]iodocyanopindolol(ICYP) binding to beta adrenergic receptor was determined None 980.0 nM
Inhibition of spontaneous contractions in isolated rat uterus Rattus norvegicus 0.1 nM
Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterus None 0.1 nM
Concentration required to effect a 50% relaxation of rat ferret detrusor basal tone Mustela putorius furo 87.0 nM
Beta adrenergic receptor agonistic activity for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cells None 7.0 nM
Inhibitory concentration required for displacement of Beta adrenergic receptor specific ligand [3H]dihydroalprenolol from rat brain cerebral cortical membranes None 100.0 nM
Agonistic activity for Beta-3 adrenergic receptor as relaxing ability of isolated ferret detrusor basal tone Mustela putorius furo 87.1 nM
The compound was evaluated for the inhibition of [125I]cyanopindolol binding to beta adrenergic receptor in rat reticulocyte membrane. None 325.0 nM
In vitro beta adrenergic receptor activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol release from adipocytes. None 13.0 nM
Agonistic activity (beta-1 adrenergic receptor) for the percent maximal increase in contraction rate of isolated guinea pig atria Cavia porcellus 6.0 nM
Activity against human beta 1 adrenergic receptor (AR), expressed in CHO cells. None 1.0 nM
Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cells None 0.1585 nM
Agonistic activity (beta2- adrenergic) for the percent maximal relaxation of isolated guinea pig trachea Cavia porcellus 58.0 nM
Activity against human beta 3 adrenergic receptor (AR), expressed in CHO cells. None 3.162 nM
Effective concentration for increasing potency force in guinea pig isolated left atria Cavia porcellus 3.2 nM
Effective concentration for increasing potency rate in guinea pig isolated right atria Cavia porcellus 6.2 nM
Compound was evaluated in vitro by SDT (Schultz-Dale Test) against isolated guinea pig lung strips repeatedly challenged with antigen in the presence of an antihistamine (H1) at a concentration 30 uM. Cavia porcellus 150.0 nM
In vitro concentration required to produce 50% relaxation of rat detrusor Rattus norvegicus 10.0 nM
The compound was evaluated for its ability to stimulate adenylate cyclase activity Rattus norvegicus 226.0 nM
KD constant value was evaluated for the displacement of ICYP (iodocyanopindolol) binding in SF-49 lymphoma cell Mus musculus 9.8e-07
Compound is tested for EC50, the mean concentration required to produce 50% relaxation of ferret detrusor in vitro Mustela putorius furo 87.1 nM
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by stimulation of rate of contraction of guinea pig atria Cavia porcellus 1.5 nM
In vitro beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucose incorporation into glycogen in isolated rat soleus muscle None 5.3 nM
Agonistic activity towards beta-2 adrenoceptor. IC50, the mean concentration required to produce 50% inhibition of uterine contraction None 0.1 nM
Agonistic activity towards beta-3 adrenoceptor. EC50, the mean concentration required to produce 50% relaxation of detrusor before the addition in the ferret detrusor None 87.1 nM
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor None 0.084 nM
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-2 adrenergic receptor Homo sapiens 2.0 nM
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-3 adrenergic receptor None 0.97 nM
Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP production Homo sapiens 3.162 nM
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production Homo sapiens 0.1585 nM
Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP production Homo sapiens 1.0 nM
Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Homo sapiens 0.97 nM
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Homo sapiens 0.084 nM
Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method Homo sapiens 5.8 nM
Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay Homo sapiens 3.9 nM
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Homo sapiens 0.084 nM
Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Homo sapiens 0.97 nM
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Homo sapiens 2.0 nM
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Homo sapiens 0.84 nM
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Homo sapiens 2.0 nM
Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Homo sapiens 0.97 nM
Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 100.0 nM
Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 3.0 nM
Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 12.0 nM
Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 0.97 nM
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 0.084 nM
Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 2.0 nM
Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 0.97 nM
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 0.084 nM
Agonist activity at human cloned beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay Homo sapiens 7.943 nM
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay Homo sapiens 39.81 nM
Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay Homo sapiens 39.81 nM
Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay Homo sapiens 100.0 nM
Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay Homo sapiens 3.0 nM
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay Homo sapiens 12.0 nM
Binding affinity to human adrenergic beta2 receptor Homo sapiens 50.0 nM
Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay Homo sapiens 100.0 nM
Agonist activity at human cloned adrenergic beta2 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay Homo sapiens 3.0 nM
Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassay Homo sapiens 12.0 nM
Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay Homo sapiens 2.0 nM
Agonist activity at human recombinant adrenergic beta2 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme immunoassay Homo sapiens 0.84 nM
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins Homo sapiens 39.81 nM
Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins Homo sapiens 7.943 nM
Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins Homo sapiens 39.81 nM
Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells Homo sapiens 90.0 nM
Displacement of [3H]dihydroalprenolol from human beta-2 adrenergic receptor delta 5-C271/W135 mutant labeled with bimane by competition binding assay Homo sapiens 150.0 nM
Displacement of [3H]dihydroalprenolol from human beta-2 adrenergic receptor delta 5-C271/W135 mutant by competition binding assay Homo sapiens 370.0 nM
Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells Homo sapiens 50.0 nM
Induction of lipolysis in mouse C3H10T1/2 assessed as glycerol concentration Mus musculus 19.0 nM
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr Homo sapiens 39.81 nM
Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 39.81 nM
Agonist activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 7.943 nM
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 39.81 nM
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 39.81 nM
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 7.943 nM
Agonist activity at human beta3 receptor expressed in CHO cells assessed as cAMP accumulation Homo sapiens 39.81 nM
DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) None 333.0 nM DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) None 193.0 nM
DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) None 246.0 nM DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) None 169.0 nM
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction Cavia porcellus 31.62 nM
Agonist activity at beta2-adrenoceptor in guinea pig trachea assessed as relaxation of histamine-induced precontracted tracheal rings Cavia porcellus 28.84 nM
Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM Homo sapiens 251.19 nM
Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction Cavia porcellus 31.62 nM Agonist activity at guinea pig trachea beta2-adrenergic receptor assessed as relaxation of histamine-induced tracheal ring contraction Cavia porcellus 31.64 nM
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation Homo sapiens 0.2 nM
Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis Homo sapiens 2.44 nM
Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis Homo sapiens 192.0 nM
Antiallergic activity in antiovalbumin serum sensitized guinea pig lung slices assessed as inhibition of ovalbumin-induced histamine release at 0.3 uM preincubated for 5 mins followed by ovalbumin challenge measured after 15 mins by fluorometric analysis relative to control Cavia porcellus 49.0 %
Bronchodilator activity in dog assessed as degree of inhibition of carbachol or histamine-induced bronchoconstriction at 0.3 to 2 mg/kg, iv relative to control Canis lupus familiaris 70.0 %
Bronchodilator activity in dog assessed as degree of inhibition of carbachol or histamine-induced bronchoconstriction at 50 to 240 mg/kg, id relative to control Canis lupus familiaris 20.0 %
Bronchodilator activity in dog assessed as degree of inhibition of carbachol or histamine-induced bronchoconstriction at 125 to 250 mg/kg, it relative to control Canis lupus familiaris 70.0 %
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring at basal tone assessed as bronchorelaxation activity Cavia porcellus 25.12 nM
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction Cavia porcellus 17.78 nM
Agonist activity at human recombinant beta3-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins Homo sapiens 86.0 nM
Displacement of [3H]CGP12177 from mouse beta1 receptor expressed in HEK293 cells Mus musculus 220.0 nM
Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells Homo sapiens 46.0 nM
Agonist activity at human beta2 receptor expressed in HEK293 cells cotransfected with Gqs5 protein assessed as [3H]IP3 accumulation after 120 mins by scintillation counting assay in presence of myo-[3H]-inositol Homo sapiens 87.0 nM
Agonist activity at PK-tagged beta2 receptor (unknown origin) transfected in HEK293 cells after 90 mins by beta-arrestin assay Homo sapiens 120.0 nM
Agonist activity at recombinant human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins Homo sapiens 86.0 nM
Agonist activity at recombinant human beta1 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins Homo sapiens 3.2 nM
Agonist activity at recombinant human beta2 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins Homo sapiens 13.0 nM
Agonist activity at human beta2-AR expressed in CHOK1 cells co-expressing Galpha15 measured after 21 secs to 120 secs by Calcium-4 dye based FLIPR assay Homo sapiens 0.7 nM
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay Homo sapiens 0.3162 nM
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay Homo sapiens 3.162 nM
Agonist activity at human beta3 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay Homo sapiens 53.7 nM
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay Homo sapiens 0.3162 nM
Agonist activity at human beta1 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay Homo sapiens 3.162 nM
Agonist activity at human beta2 adrenergic receptor expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium influx by measuring fluorescence intensity by FLIPR assay Homo sapiens 1.2 nM
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle contraction by measuring spasmolysis preincubated for 15 mins in presence of beta adrenergic receptor antagonist propranolol followed by histamine addition Cavia porcellus 7.9 nM
Agonist activity at human TAS2R1 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R8 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R13 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R7 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R3 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R43 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R38 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R45 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R46 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R50 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R5 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R55 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R16 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R10 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R48 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R41 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R40 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R60 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R49 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R47 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R39 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R9 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Agonist activity at human TAS2R4 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay Homo sapiens 4.9 nM
Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation counting Homo sapiens 130.0 nM
Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintillation counting Homo sapiens 740.0 nM
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 17.95 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.07 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.07 %
Agonist activity at human beta1 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation Homo sapiens 1.259 nM
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation Homo sapiens 0.2138 nM

Related Entries

Cross References

Resources Reference
ChEBI 64317
ChEMBL CHEMBL434
DrugBank DB01064
DrugCentral 1499
FDA SRS L628TT009W
Human Metabolome Database HMDB0015197
Guide to Pharmacology 536
KEGG C07056
PharmGKB PA450121
PubChem 3779
SureChEMBL SCHEMBL4165
CONTENTS