IBUDILAST


InChI Key	ZJVFLBOZORBYFE-UHFFFAOYSA-N
Smiles	CC(C)C(=O)c1c(C(C)C)nn2ccccc12
InChI	InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

Mechanism of Action	Action	Reference
Phosphodiesterase 10A inhibitor	INHIBITOR	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	6.03
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4A	900	54-54	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B	-	65-65	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4C	-	239-239	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D	-	166-166	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	64.5
Homo sapiens	-	54-239	-	-	6.03


Protein: Phosphodiesterase 5A Description: cGMP-specific 3',5'-cyclic phosphodiesterase Organism : Homo sapiens O76074 ENSG00000138735












Protein: Phosphodiesterase 4 Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4A Organism : Homo sapiens P27815 ENSG00000065989











Protein: Phosphodiesterase 4 Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4B Organism : Homo sapiens Q07343 ENSG00000184588













Protein: Phosphodiesterase 4 Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4C Organism : Homo sapiens Q08493 ENSG00000105650








Protein: Phosphodiesterase 4 Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4D Organism : Homo sapiens Q08499 ENSG00000113448












Protein: Phosphodiesterase 3A Description: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Organism : Homo sapiens Q14432 ENSG00000172572











Protein: Phosphodiesterase 10A Description: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Organism : Homo sapiens Q9Y233 ENSG00000112541

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