Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (relaxation) at a mepyramine concentration of 100 nM
|
Cavia porcellus
|
10.0
nM
|
|
Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM
|
Cavia porcellus
|
0.7762
nM
|
|
In vitro H1 agonistic activity by taking guinea pig ileum contraction
|
Cavia porcellus
|
140.0
nM
|
|
In vitro chronotropic effect of histamine at 5 ug/mL in guinea pig atrium
|
Cavia porcellus
|
980.0
nM
|
|
In vitro contractile response of histamine at 0.5 ug/mL in guinea pig ileum
|
Cavia porcellus
|
240.0
nM
|
|
Full pA2 value of compound at 0.3-100 nM concentration of mepyramine in guinea pig ileum
|
Cavia porcellus
|
0.8511
nM
|
|
Effective concentration for agonism activity in Endothelium-Denuded guinea pig aortic segment
|
Cavia porcellus
|
316.23
nM
|
|
Effective concentration for agonism activity in guinea pig ileal whole segment
|
Cavia porcellus
|
199.53
nM
|
|
Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig cortical homogenates
|
Cavia porcellus
|
0.1445
nM
|
|
Binding affinity towards histamine H3 receptor using [3H](R)-alpha-methylhistamine as radioligand in guinea pig ileum LMMP homogenates
|
Cavia porcellus
|
10.47
nM
|
|
Inhibition of human Histamine H3 receptor using [3H]N-alpha-methyl histamine
|
Homo sapiens
|
77.0
nM
|
|
Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H3 receptor
|
None
|
4.074
nM
|
|
Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H3 receptor
|
None
|
9.772
nM
|
|
Histamine H3 receptor competition binding using [3H]Na-methylhistamine
|
None
|
33.88
nM
|
|
Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptor
|
None
|
9.333
nM
|
|
Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM
|
Cavia porcellus
|
1.0
nM
|
|
Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum
|
Cavia porcellus
|
0.8511
nM
|
|
Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.
|
Cavia porcellus
|
0.7762
nM
|
|
Relative potency against Histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta
|
Cavia porcellus
|
1.0
nM
|
|
Effective concentration against histamine H1 receptor in endothelium-Denuded rings of guinea pig Aorta
|
Cavia porcellus
|
162.18
nM
|
|
Effective concentration against histamine H1 receptor in guinea pig ileum
|
Cavia porcellus
|
199.53
nM
|
|
Inhibition of human Histamine H1 receptor using [3H]pyrilamine
|
Homo sapiens
|
13.0
nM
|
|
Inhibitory activity against human Histamine H1 receptor
|
None
|
158.49
nM
|
|
Relative potency against Histamine H1 receptor in rat aorta
|
None
|
10.0
nM
|
|
Inhibition of human Histamine H2 receptor using [3H]tiotidine
|
Homo sapiens
|
463.0
nM
|
|
In vitro binding affinity was measured against Histamine H3 receptor on rat cerebral cortex.
|
None
|
6.31
nM
|
|
Inhibition of human Histamine H4 receptor
|
Homo sapiens
|
75.0
nM
|
|
Inhibition of the forskolin-stimulated cAMP production in SK-N-MC cells expressing human Histamine H4 receptor
|
None
|
20.89
nM
|
|
Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor
|
None
|
54.95
nM
|
|
Inhibition of [3H]-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor
|
Homo sapiens
|
14.45
nM
|
|
Compound was evaluated for mepyramine antagonism effects in guinea pig ileum (contraction) at a mepyramine concentration of 100 nM
|
Cavia porcellus
|
0.8511
nM
|
|
In vitro H3 agonistic activity against K+ induced histamine in slices of rat brain cortex.
|
Rattus norvegicus
|
62.0
nM
|
|
Binding affinity towards human histamine H4 receptor was determined by [3H]Na-methylhistamine binding to SK-N-MC cell membranes
|
Homo sapiens
|
7.943
nM
|
|
Agonist activity at histamine H1 receptor in guinea pig ileum
|
Cavia porcellus
|
199.53
nM
|
|
Agonist activity at human H1 receptor expressed in 293-EBNA cells by luciferase reporter gene assay
|
Homo sapiens
|
45.0
nM
|
|
Agonist activity at human H2 receptor expressed in 293-EBNA cells by luciferase reporter gene assay
|
Homo sapiens
|
650.0
nM
|
|
Agonist activity at human H3 receptor expressed in 293-EBNA cells by luciferase reporter gene assay
|
Homo sapiens
|
88.0
nM
|
|
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells
|
Homo sapiens
|
12.02
nM
|
|
Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay
|
Homo sapiens
|
190.0
nM
|
|
Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, G-beta-1-gamma-2 and RGS4 by steady-state GTPase activity assay
|
Homo sapiens
|
25.1
nM
|
|
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-state GTPase activity assay
|
Homo sapiens
|
11.6
nM
|
|
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy
|
Homo sapiens
|
4.1
%
|
|
Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells
|
Homo sapiens
|
13.4
nM
|
|
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting
|
Homo sapiens
|
190.55
nM
|
|
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding by liquid scintillation counting
|
Homo sapiens
|
25.12
nM
|
|
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[32P]GTP binding by liquid scintillation counting
|
Homo sapiens
|
12.02
nM
|
|
Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HEK293 cells
|
Mus musculus
|
68.0
nM
|
|
Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of [35S]GTPgammaS binding
|
Homo sapiens
|
13.8
nM
|
|
Agonist activity at human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 assessed as stimulation of GTPase by [gamma-32P]GTP spontaneous degradation assay
|
Homo sapiens
|
11.75
nM
|
|
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells
|
Homo sapiens
|
12.02
nM
|
|
Agonist activity at human histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase assay
|
Homo sapiens
|
190.55
nM
|
|
Agonist activity at human histamine H3 receptor expressed in Sf9 cells coexpressing Gialpha-2-Gbeta-1-gamma-2 and RGS4 proteins protein by steady-state GTPase assay
|
Homo sapiens
|
25.12
nM
|
|
Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay
|
Homo sapiens
|
12.02
nM
|
|
Activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay
|
Homo sapiens
|
190.55
nM
|
|
Activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 and RGS4 by steady-state GTPase activity assay
|
Homo sapiens
|
12.88
nM
|
|
Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activity assay
|
Homo sapiens
|
9.12
nM
|
|
Displacement of [3H[N-alpha-methylhistamine form human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation counting
|
Homo sapiens
|
5.2
nM
|
|
Agonist activity at human recombinant histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillation counting
|
Homo sapiens
|
640.0
nM
|
|
Displacement of [3H]histamine from human recombinant histamine H4 receptor
|
Homo sapiens
|
60.0
nM
|
|
Agonist activity at rat histamine H4 receptor by luciferase reporter gene assay
|
Rattus norvegicus
|
158.49
nM
|
|
Binding affinity to dog histamine H4 receptor expressed in COS7 cells by radioligand displacement assay
|
Canis lupus familiaris
|
63.1
nM
|
|
Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 by steady-state GTPase activity assay
|
Homo sapiens
|
199.53
nM
|
|
Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2
|
Homo sapiens
|
7.943
nM
|
|
Agonist activity at human recombinant histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2 by steady-state GTPase activity assay
|
Homo sapiens
|
12.59
nM
|
|
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells
|
Homo sapiens
|
10.0
nM
|
|
Agonist activity at human histamine H3 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay
|
Homo sapiens
|
5.012
nM
|
|
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay
|
Homo sapiens
|
19.95
nM
|
|
Binding affinity to human recombinant histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay
|
Homo sapiens
|
12.59
nM
|
|
Agonist activity at human recombinant histamine H4 receptor expressed in human SK-N-MC cells co-expressing SRE-Luc by luciferase reporter gene assay
|
Homo sapiens
|
79.43
nM
|
|
Binding affinity to mouse histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay
|
Mus musculus
|
79.43
nM
|
|
Binding affinity to rat histamine H4 receptor expressed in human SK-N-MC cells by radioligand displacement assay
|
Rattus norvegicus
|
63.1
nM
|
|
Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay
|
Plasmodium falciparum
|
660.0
nM
|
|
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting
|
Homo sapiens
|
11.75
nM
|
|
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting
|
Homo sapiens
|
12.02
nM
|
|
Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay
|
Homo sapiens
|
25.12
nM
|
|
Agonist activity at human histamine H3 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferase reporter gene assay
|
Homo sapiens
|
15.85
nM
|
|
Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting
|
Homo sapiens
|
6.31
nM
|
|
Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting
|
Homo sapiens
|
15.85
nM
|
|
Displacement of [3H]histamine from human H4 receptor expressed in HEK cell membranes
|
Homo sapiens
|
9.0
nM
|
|
Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1 hr by liquid scintillation counting analysis
|
Homo sapiens
|
19.95
nM
|
|
Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting
|
Homo sapiens
|
20.42
nM
|
|
Agonist activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 and RGS4 assessed as [35S]GTPgammaS binding after 90 mins by liquid scintillation counting
|
Homo sapiens
|
12.88
nM
|
|
Agonist activity at human recombinant histamine H4 receptor-RGS19 fusion protein expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay
|
Homo sapiens
|
12.02
nM
|
|
Agonist activity at human recombinant histamine H3 receptor expressed in Sf9 cells coexpressing Galphai2,Gbeta1gamma2 and RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay
|
Homo sapiens
|
25.12
nM
|
|
Agonist activity at human recombinant histamine H1 receptor expressed in Sf9 cells coexpressing RGS4 preincubated for 2 mins before [gamma32P]GTP addition measured after 20 mins by steady-state GTPase activity assay
|
Homo sapiens
|
190.55
nM
|
|
Binding affinity to histamine H4 receptor (unknown origin)
|
Homo sapiens
|
8.0
nM
|
|
Binding affinity to histamine H3 receptor (unknown origin)
|
Homo sapiens
|
16.0
nM
|
|
Binding affinity to human histamine H4 receptor
|
Homo sapiens
|
4.8
nM
|
|
Binding affinity to guinea pig histamine H4 receptor
|
Cavia porcellus
|
6.0
nM
|
|
Binding affinity to mouse histamine H4 receptor
|
Mus musculus
|
42.0
nM
|
|
Binding affinity to rat histamine H4 receptor
|
Rattus norvegicus
|
136.0
nM
|
|
Displacement of [3H]-histamine from human histamine H4 receptor expressed in human SK-N-MC cells after 1 hr
|
Homo sapiens
|
15.85
nM
|
|
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS binding by scintillation counting
|
Homo sapiens
|
7.943
nM
|
|
Agonist activity at human histamine H3 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay
|
Homo sapiens
|
13.0
nM
|
|
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 mins by [35S]GTPgammaS binding assay
|
Homo sapiens
|
11.0
nM
|
|
Agonist activity at human histamine H1 receptor expressed in sf9 cell membrane co-expressing RGS4 or RGS9 assessed as increase in 32Pi level incubated for 20 mins by liquid scintillation counting in presence of [gamma32P]GTP
|
Homo sapiens
|
190.0
nM
|
|
Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay
|
Homo sapiens
|
13.0
nM
|
|
Agonist activity at mouse SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incubated for 5 hrs by luciferase reporter gene assay
|
Mus musculus
|
94.0
nM
|
|
Binding affinity to histamine H4 receptor (unknown origin)
|
Homo sapiens
|
1.6
nM
|
|
Binding affinity to histamine H3 receptor (unknown origin)
|
Homo sapiens
|
12.8
nM
|
|
Binding affinity to human H4R
|
Homo sapiens
|
5.0
nM
|
|
Binding affinity to mouse H4R
|
Mus musculus
|
42.0
nM
|
|
Binding affinity to rat H4R
|
Rattus norvegicus
|
134.0
nM
|
|
Agonist activity at human H4R by [35S]-GTPgammaS-binding assay
|
Homo sapiens
|
7.413
nM
|
|
Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay
|
Homo sapiens
|
16.98
nM
|
|
Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay
|
Homo sapiens
|
33.88
nM
|
|
Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay
|
Mus musculus
|
87.1
nM
|
|
Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay
|
Rattus norvegicus
|
295.12
nM
|
|
Displacement of [3H]NAMH from human H3R expressed in HEK293T cells incubated for 2 hrs by microbeta scintillation counting analysis
|
Homo sapiens
|
12.59
nM
|
|
Agonist activity at human H3R expressed on HEK293T cells assessed as inhibition of forskolin-induced CRE-driven luciferase activity co-incubated with forskolin for 6 hrs and measured after 30 mins by CRE-luciferase reporter gene assay
|
Homo sapiens
|
2.512
nM
|
|
Agonist activity at human H3R expressed on HEK293T cells by [35S]GTPgammaS binding assay
|
Homo sapiens
|
63.1
nM
|
|
Displacement of [3H]-N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells incubated for 40 min by liquid scintillation counting analysis
|
Homo sapiens
|
10.0
nM
|
|
Agonist activity at human H3R expressed on SK-N-MC cells assessed as inhibition of forskolin-induced beta galactosidase activity preincubated with forskolin for 6 hrs followed compound addition by CRE-luciferase reporter gene assay
|
Homo sapiens
|
5.012
nM
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
19.79
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
12.67
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.03
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.3
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.03
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.3
%
|
|
Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation counting method
|
Homo sapiens
|
295.12
nM
|
|
Agonist activity at human H3 receptor stably transfected in CHO-DUKX cells assessed as increase in cAMP accumulation by measuring reduction in forskolin level by HitHunter-cAMP assay
|
Homo sapiens
|
30.0
nM
|
|
Agonist activity at human H3 receptor expressed in CHO cells assessed as increase in cAMP accumulation by measuring reduction in forskolin level incubated for 4 hrs by CRE/MRE-luciferase reporter gene assay
|
Homo sapiens
|
4.0
nM
|
|
Displacement of [3H]-Histamine from human histamine 4 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis
|
Homo sapiens
|
1.0
nM
|
|
Displacement of [3H]-Histamine from human histamine 3 receptor transfected in HEK293T cells incubated for 16 hrs by liquid scintillation counter analysis
|
Homo sapiens
|
2.512
nM
|
|
Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by microbeta scintillation counting method
|
Homo sapiens
|
263.03
nM
|
|
Displacement of [3H]UR-P129 from human histamine H3 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method
|
Homo sapiens
|
25.7
nM
|
|
Displacement of [3H]histamine from human histamine H4 receptor expressed in sf9 insect cell membranes co-expressing Galphai2/Gbeta1gamma2 incubated for 60 mins by microbeta scintillation counting method
|
Homo sapiens
|
25.12
nM
|
|
Agonist activity at guinea pig right atrium histamine H2 receptor assessed as increase in heart rate incubated for 30 mins in presence of cimetidine
|
Cavia porcellus
|
691.83
nM
|
|
Agonist activity at human histamine receptor expressed in sf9 insect cell membranes co-exprssing GsalphaS incubated for 90 mins [35S]GTPgammaS binding based microbeta scintillation counting analysis
|
Homo sapiens
|
977.24
nM
|
|
Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assay
|
Homo sapiens
|
588.84
nM
|
|
Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assay
|
Homo sapiens
|
501.19
nM
|
|
Agonist activity at human H2 receptor expressed in HEK293T-ARRB2 cells assessed as stimulation of beta-arrestin 2 recruitment
|
Homo sapiens
|
114.82
nM
|
|
Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in Sf9 cell membranes by competitive binding assay
|
Homo sapiens
|
263.03
nM
|
|