Binding affinity against Synechocystis strain PCC6803 DXP reductoisomerase
|
Synechocystis sp. PCC 6803
|
21.0
nM
|
|
Inhibitory concentration against DOXP reductoisomerase
|
Escherichia coli
|
19.95
nM
|
|
Inhibition of recombinant Escherichia coli DXR
|
Escherichia coli
|
48.0
nM
|
|
Inhibition of Plasmodium falciparum Dd2
|
Plasmodium falciparum
|
480.0
nM
|
|
Inhibition of Plasmodium falciparum 3D7
|
Plasmodium falciparum
|
400.0
nM
|
|
Inhibition of recombinant Escherichia coli DXR
|
Escherichia coli
|
30.0
nM
|
|
Antimalarial activity against Plasmodium falciparum Dd2
|
Plasmodium falciparum
|
360.0
nM
|
|
Inhibition of Trypanosoma brucei FPPS expressed in Escherichia coli
|
Trypanosoma brucei
|
200.0
nM
|
|
Antibacterial activity against Escherichia coli K12 by broth microdilution method
|
Escherichia coli
|
220.0
nM
|
|
Inhibition of Escherichia coli DXR
|
Escherichia coli
|
34.0
nM
|
|
Inhibition of Escherichia coli DXR
|
Escherichia coli
|
54.0
nM
|
|
Inhibition of Escherichia coli DXR by spectrophotometric method
|
Escherichia coli
|
30.0
nM
|
|
Inhibition of Mycobacterium tuberculosis DXR assessed as NADPH-dependent conversion of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate by spectrophotometric method
|
Mycobacterium tuberculosis
|
80.0
nM
|
|
Inhibition of Escherichia coli M15 DXR
|
Escherichia coli
|
80.0
nM
|
|
Antiplasmodial activity against Plasmodium berghei ANKA infected in mice (Mus musculus) assessed as suppression of parasitaemia at 50 mg/kg, intraperitoneal for 5 consecutive days measured on day 4 post parasitic infection
|
Plasmodium berghei str. ANKA
|
82.0
%
|
|
Inhibition of Escherichia coli DXR
|
Escherichia coli
|
30.0
nM
|
|
Inhibition of Escherichia coli DXR assessed as conversion of NADPH to NADP at 0.3 uM by spectrophotometry
|
Escherichia coli
|
99.3
%
|
|
Inhibition of Escherichia coli recombinant DXR using DXP as substrate and MgCl2 as cofactor preincubated for 10 mins
|
Escherichia coli
|
26.92
nM
|
|
Inhibition of Escherichia coli recombinant DXR using DXP as substrate and MgCl2 as cofactor preincubated for 10 mins
|
Escherichia coli
|
27.0
nM
|
|
Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preincubated for 10 mins
|
Mycobacterium tuberculosis
|
140.0
nM
|
|
Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and Mn2+ as cofactor preincubated for 10 mins
|
Mycobacterium tuberculosis
|
80.0
nM
|
|
Inhibition of Mycobacterium tuberculosis DXR-catalyzed NADPH-dependent rearrangement and reduction of DXP to form MEP measured every 5 secs for 500 secs by spectrophotometric analysis
|
Mycobacterium tuberculosis
|
80.0
nM
|
|
Inhibition of Mycobacterium tuberculosis DXR assessed as reduction of 1-deoxy-D-xylulose 5-phosphate into 2-C-methyl-D-erythritol-4-phosphate measured for every 5 secs upto 500 secs by spectrophotometry analysis
|
Mycobacterium tuberculosis
|
80.0
nM
|
|
Inhibition of Plasmodium falciparum IspC
|
Plasmodium falciparum
|
140.0
nM
|
|
Inhibition of Escherichia coli IspC
|
Escherichia coli
|
220.0
nM
|
|
Inhibition of Mycobacterium smegmatis DXR
|
Mycobacterium smegmatis
|
80.0
nM
|
|
Inhibition of Mycobacterium smegmatis DSM 43756 ATCC 19420 N-terminal his-tagged DXR expressed in XL1-blue Escherichia coli using NADPH and DXP as substrate preincubated for 2 mins with substrate before compound addition
|
Mycobacterium smegmatis
|
510.0
nM
|
|
Inhibition of Escherichia coli DXR using DXP as substrate preincubated for 5 mins
|
Escherichia coli
|
27.0
nM
|
|
Inhibition of His6-tagged Plasmodium falciparum DXR expressed in Escherichia coli M15 using DXP as substrate preincubated for 5 mins
|
Plasmodium falciparum
|
21.0
nM
|
|
Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate preincubated for 5 mins
|
Mycobacterium tuberculosis
|
140.0
nM
|
|
Inhibition of Escherichia coli recombinant His6-tagged DXR expressed in Escherichia coli XL-1 blue using DXP as substrate after 5 mins by spectrophotometric analysis
|
Escherichia coli
|
250.0
nM
|
|
Inhibition of Escherichia coli recombinant His6-tagged DXR expressed in Escherichia coli XL-1 blue using DXP as substrate incubated for 2 mins prior to substrate addition measured after 5 mins by spectrophotometric analysis
|
Escherichia coli
|
32.0
nM
|
|
Inhibition of Arabidopsis thaliana IspC expressed in Escherichia coli after 40 min by spectrophotometric analysis
|
Arabidopsis thaliana
|
100.0
nM
|
|
Inhibition of Plasmodium falciparum recombinant DXR using DXP as substrate preincubated for 5 mins
|
Plasmodium falciparum
|
21.0
nM
|
|
Inhibition of Escherichia coli recombinant DXR using DXP as substrate preincubated for 5 mins
|
Escherichia coli
|
34.0
nM
|
|
Antimalarial activity against Plasmodium falciparum Dd2 after 3 days by SYBR green I assay
|
Plasmodium falciparum
|
440.0
nM
|
|
Inhibition of N-terminal His6-tagged Escherichia coli DXR after 2 mins in presence of NADPH
|
Escherichia coli
|
32.0
nM
|
|
Inhibition of recombinant Toxoplasma gondii DXR catalytic domain (68 to 513) expressed in Escherichia coli BL21 using DXP as substrate after 10 mins by Uv-spectrophotometric analysis
|
Toxoplasma gondii
|
90.0
nM
|
|
Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate assessed as formation of MEP measured every 5 secs for 180 secs by spectrophotometric analysis
|
Mycobacterium tuberculosis
|
80.0
nM
|
|
Binding affinity to Mycobacterium tuberculosis DXR assessed as dissociation constant by spectrofluorimetric analysis in presence of NADPH and MnCl2
|
Mycobacterium tuberculosis
|
40.0
nM
|
|
Inhibition of Plasmodium falciparum DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPH
|
Plasmodium falciparum
|
32.0
nM
|
|
Inhibition of Escherichia coli DXR using DXP as substrate measured every 5 secs for 250 secs in presence of NADPH
|
Escherichia coli
|
50.0
nM
|
|
Inhibition of Mycobacterium tuberculosis IspC by photometric assay
|
Mycobacterium tuberculosis
|
230.0
nM
|
|
Inhibition of Escherichia coli IspC by photometric assay
|
Escherichia coli
|
221.0
nM
|
|
Inhibition of Mycobacterium tuberculosis Dxr
|
Mycobacterium tuberculosis
|
440.0
nM
|
|
Inhibition of His-tagged Mycobacterium tuberculosis DXR expressed in Escherichia coli BL21(DE3) using DXP as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by NADPH and substrate addition by spectrophotometric analysis
|
Mycobacterium tuberculosis
|
310.0
nM
|
|
Inhibition of Escherichia coli IspC
|
Escherichia coli
|
35.0
nM
|
|
Inhibition of Escherichia coli Dxr
|
Escherichia coli
|
32.0
nM
|
|
Inhibition of His-tagged Escherichia coli DXR pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100
|
Escherichia coli
|
32.0
nM
|
|
Antimalarial activity against MRA-150, chloroquine, pyrimethamine, mefloquine-resistant asexual blood stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay
|
Plasmodium falciparum Dd2
|
880.0
nM
|
|
Antimalarial activity against chloroquine and mefloquine-resistant Plasmodium falciparum Dd2 after 48 hrs by SYBR Green I assay
|
Plasmodium falciparum Dd2
|
810.0
nM
|
|
Inhibition of recombinant Plasmodium falciparum IspC using [3,4,5-13C3]1-Deoxy-D-xylulose 5-phosphate substrate by photometric assay
|
Plasmodium falciparum
|
160.0
nM
|
|
Antiplasmodial activity against blood stage forms of multidrug-resistant Plasmodium falciparum Dd2 incubated for 3 days by HRP2 detection based ELISA method
|
Plasmodium falciparum Dd2
|
810.0
nM
|
|
Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method
|
Plasmodium falciparum 3D7
|
880.0
nM
|
|
Inhibition of recombinant Escherichia coli Dxr expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells using DOXP as substrate assessed as NADPH oxidation preincubated for 5 mins with NADPH followed by substrate addition by spectrophotometric analysis
|
Escherichia coli
|
438.0
nM
|
|
Inhibition of recombinant Plasmodium falciparum Dxr expressed in Escherichia coli C43(DE3) using DOXP as substrate assessed as NADPH oxidation by spectrophotometric analysis
|
Plasmodium falciparum
|
36.0
nM
|
|
Inhibition of Escherichia coli His6-tagged DXR preincubated for 2 mins in presence of NADPH followed by DXP substrate addition
|
Escherichia coli
|
42.0
nM
|
|
Antimalarial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability by [3H]-hypoxanthine incorporation assay
|
Plasmodium falciparum
|
290.0
nM
|
|