FASIGLIFAM

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Search structure


Synonyms	Fasiglifam Fasiglifam hemihydrate TAK-875 Tak-875 anhydrous
Status
Molecule Category	Free-form
UNII	GLP1W4JXAH

Structure


InChI Key	BZCALJIHZVNMGJ-HSZRJFAPSA-N
Smiles	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3c(c2)OC[C@H]3CC(=O)O)c1
InChI	InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C29H32O7S
Molecular Weight	524.64
AlogP	5.31
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	11.0
Polar Surface Area	99.13
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	37.0

Pharmacology

Mechanism of Action	Action	Reference
Free fatty acid receptor 1 positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 1 Cytochrome P450 family 1A Cytochrome P450 1A2	-	-	-	-	28
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9	-	-	-	-	21.02
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6	-	-	-	-	23.22
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	-	-	-	33.96
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Free fatty acid receptor	0.35-160	-	4.5-11.9	7.7-28.84	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	0.35-160	-	4.5-11.9	7.7-28.84	21.02-33.96
Mus musculus	8.6	-	-	-	21.4
Rattus norvegicus	36-39	-	-	-	-

Target Conservation


Protein: Free fatty acid receptor 1 Description: Free fatty acid receptor 1 Organism : Homo sapiens O14842 ENSG00000126266

Cross References

Resources	Reference
ChEMBL	CHEMBL1829174
DrugBank	DB12491
FDA SRS	GLP1W4JXAH
Guide to Pharmacology	6484
PDB	2YB
PubChem	24857286
SureChEMBL	SCHEMBL204652
ZINC	ZINC000068208039

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025