FAROPENEM

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category UNKNOWN
ATC J01DI03
UNII F52Y83BGH3
EPA CompTox DTXSID0046430

Structure

InChI Key HGGAKXAHAYOLDJ-FHZUQPTBSA-N
Smiles C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C([C@H]3CCCO3)S[C@H]12
InChI
InChI=1S/C12H15NO5S/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6/h5-7,11,14H,2-4H2,1H3,(H,16,17)/t5-,6-,7+,11-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H15NO5S
Molecular Weight 285.32
AlogP 0.37
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 87.07
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 19.0

Bioactivity

Mechanism of Action Action Reference
Bacterial penicillin-binding protein inhibitor INHIBITOR PubMed Other PubMed PubMed
Assay Description Organism Bioactivity Reference
Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP1A Streptococcus pneumoniae 0.009 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP1A Streptococcus pneumoniae 0.016 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP1A Streptococcus pneumoniae 0.023 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP1A Streptococcus pneumoniae 0.025 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP1A Streptococcus pneumoniae 0.004 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP1A Streptococcus pneumoniae 0.03 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP1A Streptococcus pneumoniae 0.01 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP1A Streptococcus pneumoniae 0.015 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1A Streptococcus pneumoniae 0.015 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP1B Streptococcus pneumoniae 0.06 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP1B Streptococcus pneumoniae 0.019 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP1B Streptococcus pneumoniae 0.002 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP1B Streptococcus pneumoniae 0.005 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP1B Streptococcus pneumoniae 0.001 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP1B Streptococcus pneumoniae 0.012 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP1B Streptococcus pneumoniae 0.002 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP1B Streptococcus pneumoniae 0.002 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1B Streptococcus pneumoniae 0.005 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2X Streptococcus pneumoniae 0.758 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2X Streptococcus pneumoniae 0.435 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2X Streptococcus pneumoniae 0.033 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2X Streptococcus pneumoniae 0.017 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2X Streptococcus pneumoniae 0.039 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2X Streptococcus pneumoniae 0.173 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2X Streptococcus pneumoniae 0.061 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2X Streptococcus pneumoniae 0.063 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2X Streptococcus pneumoniae 0.196 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2A Streptococcus pneumoniae 0.023 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2A Streptococcus pneumoniae 0.007 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2A Streptococcus pneumoniae 0.025 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2A Streptococcus pneumoniae 0.053 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2A Streptococcus pneumoniae 0.015 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2A Streptococcus pneumoniae 0.016 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2A Streptococcus pneumoniae 0.035 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP2B Streptococcus pneumoniae 0.033 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2B Streptococcus pneumoniae 0.142 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP2B Streptococcus pneumoniae 0.01 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP2B Streptococcus pneumoniae 0.043 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2B Streptococcus pneumoniae 0.013 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP2B Streptococcus pneumoniae 0.047 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP2B Streptococcus pneumoniae 0.007 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP2B Streptococcus pneumoniae 0.013 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP2B Streptococcus pneumoniae 0.008 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 24 PBP3 Streptococcus pneumoniae 0.015 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP3 Streptococcus pneumoniae 0.003 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP3 Streptococcus pneumoniae 0.007 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3676 PBP3 Streptococcus pneumoniae 0.009 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP3 Streptococcus pneumoniae 0.004 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3665 PBP3 Streptococcus pneumoniae 0.005 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 3009 PBP3 Streptococcus pneumoniae 0.006 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1076 PBP3 Streptococcus pneumoniae 0.015 ug.mL-1
Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP3 Streptococcus pneumoniae 0.006 ug.mL-1

Related Entries

Cross References

Resources Reference
ChEBI 51257
ChEMBL CHEMBL556262
DrugBank DB12190
DrugCentral 1131
FDA SRS F52Y83BGH3
Human Metabolome Database HMDB0041892
Guide to Pharmacology 10808
PDB FPM
PubChem 65894
SureChEMBL SCHEMBL239381
ZINC ZINC000003959242
CONTENTS