|
Inhibition of lysosomal Alpha-Glucosidase II in rat liver
|
Rattus norvegicus
|
400.0
nM
|
|
|
Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver
|
Bos taurus
|
400.0
nM
|
|
|
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase
|
None
|
150.0
nM
|
|
|
Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestine
|
None
|
300.0
nM
|
|
|
Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver
|
Rattus norvegicus
|
400.0
nM
|
|
|
Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine
|
Rattus norvegicus
|
360.0
nM
|
|
|
Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method
|
None
|
300.0
nM
|
|
|
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method
|
Rattus norvegicus
|
360.0
nM
|
|
|
Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method
|
None
|
210.0
nM
|
|
|
Tested in vitro for the inhibition constant against rat small intestinal sucrase
|
None
|
24.0
nM
|
|
|
Competitive Inhibition constant on rice alpha Glucosidase at pH 5.0
|
rice
|
160.0
nM
|
|
|
Competitive Inhibition constant on rice alpha Glucosidase at pH 6.0
|
rice
|
14.0
nM
|
|
|
Inhibitory activity against alpha-Glucosidase from rice
|
rice
|
50.0
nM
|
|
|
Inhibitory concentration against rat intestinal maltase
|
Rattus norvegicus
|
650.0
nM
|
|
|
Inhibitory concentration against human alpha-glucosidase
|
Homo sapiens
|
40.0
nM
|
|
|
Inhibitory concentration against rice alpha-glucosidase
|
rice
|
30.0
nM
|
|
|
Inhibitory activity against rat intestinal maltase using disaccharide
|
Rattus norvegicus
|
360.0
nM
|
|
|
Inhibitory activity against rat intestinal sucrase using disaccharide
|
Rattus norvegicus
|
210.0
nM
|
|
|
Inhibitory activity against rat intestinal isomaltase using disaccharide
|
Rattus norvegicus
|
300.0
nM
|
|
|
Percent inhibition of human alpha-fucosidase at 1000 uM
|
Homo sapiens
|
50.0
%
|
|
|
Percent inhibition of human beta-mannosidase at 1000 uM
|
Homo sapiens
|
50.0
%
|
|
|
Percent inhibition of human alpha-mannosidase at 1000 uM
|
Homo sapiens
|
50.0
%
|
|
|
Percent inhibition of human beta-galactosidase at 1000 uM
|
Homo sapiens
|
50.0
%
|
|
|
Percent inhibition of human alpha-galactosidase at 1000 uM
|
Homo sapiens
|
50.0
%
|
|
|
Percent inhibition of beta galactosidase of bovine liver at 1000 uM
|
Bos taurus
|
50.0
%
|
|
|
Percent inhibition of beta-mannosidase of rat epididymis at 1000 uM
|
Rattus norvegicus
|
50.0
%
|
|
|
Percent inhibition of alpha-mannosidase of jack bean tree at 1000 uM
|
Canavalia ensiformis
|
50.0
%
|
|
|
Percent inhibition of alpha-mannosidase of rat epididymis 1000 uM
|
Rattus norvegicus
|
50.0
%
|
|
|
Percent inhibition of beta galactosidase of rat epididymis at 1000 uM
|
Rattus norvegicus
|
50.0
%
|
|
|
Percent inhibition of alpha-L-fucosidase of bovine epididymis at 1000 uM
|
Bos taurus
|
50.0
%
|
|
|
Percent inhibition of alpha-galactosidase of Aspergillus niger at 1000 uM
|
Aspergillus niger
|
50.0
%
|
|
|
Percent inhibition against sweet Almond glucosidase at 0.24 mM; n>=3
|
Prunus dulcis
|
50.0
%
|
|
|
Percent inhibition against Bovine liver galactosidase at 0.24 mM; n>=3
|
Bos taurus
|
20.0
%
|
|
|
Percent inhibition against Escherichia coli galactosidase at 0.24 mM; n>=3
|
Escherichia coli
|
20.0
%
|
|
|
Inhibition of alpha-glucosidase in 1.20 mg/200 uL
|
None
|
100.0
%
|
|
|
Inhibition of concanavalin A-induced BALB/c mouse splenocyte proliferation at 30 uM by MTT assay
|
Mus musculus
|
15.57
%
|
|
|
Inhibition of rat intestinal brush border membrane maltase
|
Rattus norvegicus
|
130.0
nM
|
|
|
Inhibition of rat intestinal brush border membrane isomaltase
|
Rattus norvegicus
|
160.0
nM
|
|
|
Inhibition of rat intestinal brush border membrane sucrase
|
Rattus norvegicus
|
210.0
nM
|
|
|
Inhibition of rabbit glycogen phosphorylase B at 400 uM
|
Oryctolagus cuniculus
|
50.0
%
|
|
|
Inhibition of rabbit muscle amylo-1,6-glucosidase
|
Oryctolagus cuniculus
|
190.0
nM
|
|
|
Inhibition of glucagon-induced glucose production in rat primary hepatocytes at 100 uM
|
Rattus norvegicus
|
25.0
%
|
|
|
Inhibition of maltase in human Caco-2 cell model system after 2 hrs
|
Homo sapiens
|
60.0
nM
|
|
|
Inhibition of rice alpha-glucosidase assessed as D-glucose release after 10 mins by Glucose B-test
|
Oryza sativa
|
50.0
nM
|
|
|
Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test
|
Rattus norvegicus
|
360.0
nM
|
|
|
Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test
|
Rattus norvegicus
|
400.0
nM
|
|
|
Inhibition of rat epididymis beta-mannosidase assessed as p-nitrophenol release at 1000 uM after 30 mins by spectrophotometry
|
Rattus norvegicus
|
50.0
%
|
|
|
Inhibition of bovine liver beta-galactosidase assessed as p-nitrophenol release at 1000 uM after 30 mins by spectrophotometry
|
Bos taurus
|
50.0
%
|
|
|
Inhibition of bovine epididymis alpha-L-fucosidase assessed as p-nitrophenol release at 1000 uM after 30 mins by spectrophotometry
|
Bos taurus
|
50.0
%
|
|
|
Inhibition of rat intestinal sucrase expressed in human Caco-2 cells at 21 uM
|
Rattus norvegicus
|
100.0
%
|
|
|
Inhibition of human intestinal sucrase in human Caco-2 cell membrane at 21 uM
|
Homo sapiens
|
95.0
%
|
|
|
Inhibition of rice alpha glucosidase
|
Oryza sativa
|
30.0
nM
|
|
|
Inhibition of Saccharomyces cerevisiae alpha glucosidase
|
Saccharomyces cerevisiae
|
500.0
nM
|
|
|
Inhibition of Bacillus stearothermophilus alpha glucosidase
|
Geobacillus stearothermophilus
|
650.0
nM
|
|
|
Inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as p-nitrophenol release by colorimetry
|
Geobacillus stearothermophilus
|
450.0
nM
|
|
|
Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate at 1000 uM by spectrophotometry
|
Bos taurus
|
50.0
%
|
|
|
Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate at 1000 uM by spectrophotometry
|
Homo sapiens
|
50.0
%
|
|
|
Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry
|
Bos taurus
|
50.0
%
|
|
|
Inhibition of jack beans alpha-mannosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry
|
Canavalia ensiformis
|
50.0
%
|
|
|
Inhibition of snail beta-mannosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry
|
Helix pomatia
|
50.0
%
|
|
|
Inhibition of bovine epididymis alpha-L-fucosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry
|
Bos taurus
|
50.0
%
|
|
|
Inhibition of Penicillium decumbens alpha-L-rhamnosidase assessed as production of p-nitrophenol at 1000 uM by spectrophotometry
|
Penicillium decumbens
|
50.0
%
|
|
|
Inhibition of rat intestinal maltase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry
|
Rattus norvegicus
|
650.0
nM
|
|
|
Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry
|
Rattus norvegicus
|
650.0
nM
|
|
|
Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry
|
Rattus norvegicus
|
510.0
nM
|
|
|
Inhibition of rice alpha-glucosidase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry
|
Oryza sativa
|
30.0
nM
|
|
|
Inhibition of Con-A-induced phospho-STAT6 expression in human PBMC at 90 uM after 72 hrs by flow cytometry (Rvb = 10.52+/-1.9%)
|
Homo sapiens
|
9.6
%
|
|
|
Inhibition of bovine liver beta-galactosidase at 1000 uM
|
Bos taurus
|
50.0
%
|
|
|
Inhibition of rat intestinal sucrase using sucrose as substrate
|
Rattus norvegicus
|
210.0
nM
|
|
|
Inhibition of rat intestinal isomaltase using isomaltase as substrate
|
Rattus norvegicus
|
300.0
nM
|
|
|
Inhibition of rat intestinal maltase using moltose as substrate
|
Rattus norvegicus
|
360.0
nM
|
|
|
Competitive inhibition of recombinant Mycobacterium smegmatis trehalose synthase using DNPGlc as substrate by Dixon plot analysis
|
Mycobacterium smegmatis
|
250.0
nM
|
|
|
Inhibition of alpha glucosidase (unknown origin) at 100 uM preincubated for 15 mins followed by p-nitrophenyl-alpha-D-glucopyranoside addition measured after 30 mins by spectrophotometric analysis
|
Homo sapiens
|
52.52
%
|
|
|
Inhibition of rice alpha-glucosidase assessed as reduction in production of D-glucose using disaccharides as substrate incubated for 10 to 30 mins
|
Oryza sativa
|
50.0
nM
|
|
|
Inhibition of alpha-glucosidase in human PBMC using 4-methylumbelliferyl alpha-D-glucopyranoside as substrate at pH 4.3 after 2 hrs by fluorescence assay
|
Homo sapiens
|
50.0
nM
|
|
|
Inhibition of alpha-glucosidase in human HepG2 cells assessed as reduction in glucose level at 5 uM measured after 24 hrs relative to control
|
Homo sapiens
|
50.0
%
|
|
|
Inhibition of yeast alpha-glucosidase at 50 uM using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by microplate reader analysis
|
Saccharomyces cerevisiae
|
36.8
%
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
7.57
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.05
%
|
|
|
Inhibition of rice alpha-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay
|
Oryza sativa
|
440.0
nM
|
|
|
Inhibition of rat intestinal maltase using maltose as substrate assessed as release of D-glucose measured by spectrometric assay
|
Rattus norvegicus
|
120.0
nM
|
|
|
Inhibition of rat intestinal sucrase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay
|
Rattus norvegicus
|
190.0
nM
|
|
|
Inhibition of rat intestinal isomaltase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol measured by spectrometric assay
|
Rattus norvegicus
|
610.0
nM
|
|
|
Inhibition of almond beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Prunus dulcis
|
12.1
%
|
|
|
Inhibition of bovine liver beta-glucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Bos taurus
|
4.6
%
|
|
|
Inhibition of coffee beans alpha-galactosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Coffea arabica
|
13.7
%
|
|
|
Inhibition of bovine liver beta-galactosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Bos taurus
|
0.0
%
|
|
|
Inhibition of jack bean alpha-mannosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Canavalia ensiformis
|
17.4
%
|
|
|
Inhibition of snail beta-mannosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Helix pomatia
|
4.8
%
|
|
|
Inhibition of bovine kidney alpha-L-fucosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Bos taurus
|
1.0
%
|
|
|
Inhibition of Penicillium decumbens alpha-L-rhamnosidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Penicillium decumbens
|
45.6
%
|
|
|
Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol at 1000 uM measured by spectrometric assay relative to control
|
Escherichia coli
|
0.8
%
|
|
|
Inhibition of beta-glucosidase (unknown origin)
|
Homo sapiens
|
270.0
nM
|
|
|
Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and measured after 30 min by fluorescence spectrophotometer analysis
|
Homo sapiens
|
59.0
nM
|
|
