Tested for percentage inhibition of PTH stimulated bone resorption in neonatal mouse calvaria placed in culture, at 10 uM concentration
|
Mus musculus
|
95.6
%
|
|
Decreased dry tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 100 mg/kg
|
Mus musculus
|
63.0
%
|
|
Decreased dry tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 100 mg/kg after 9 days
|
Mus musculus
|
50.0
%
|
|
Decreased dry tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 200 mg/kg
|
Mus musculus
|
59.0
%
|
|
Decreased dry tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 25 mg/kg
|
Mus musculus
|
45.0
%
|
|
Decreased dry tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 50 mg/kg
|
Mus musculus
|
47.0
%
|
|
Decreased wet tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 100 mg/kg
|
Mus musculus
|
61.0
%
|
|
Decreased wet tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 100 mg/kg after 9 days
|
Mus musculus
|
45.0
%
|
|
Decreased wet tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 200 mg/kg
|
Mus musculus
|
55.0
%
|
|
Decreased wet tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 25 mg/kg
|
Mus musculus
|
45.0
%
|
|
Decreased wet tissue weight of DTH-GRA from mice was determined after (sc) administration of a dose of 50 mg/kg
|
Mus musculus
|
48.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 10 mg/kg in the non-injected paw
|
Mus musculus
|
61.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 100 mg/kg
|
Mus musculus
|
51.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 15 mg/kg
|
Mus musculus
|
46.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 200 mg/kg
|
Mus musculus
|
52.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 30 mg/kg
|
Mus musculus
|
46.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 5 mg/kg
|
Mus musculus
|
4.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 5 mg/kg in the non-injected paw
|
Mus musculus
|
51.0
%
|
|
Inhibition of antigen-induced polyarthritis (AIP) in mice at the dose of 50 mg/kg
|
Mus musculus
|
46.0
%
|
|
Inhibition of delayed type hypersensitivity granuloma results at 100 mg/kg in dry weight
|
Mus musculus
|
47.0
%
|
|
Inhibition of delayed type hypersensitivity granuloma results at 100 mg/kg in wet weight
|
Mus musculus
|
45.0
%
|
|
Compound was tested for anti-inflammatory activity in delayed type hypersensitivity granuloma upon 100 mg/kg peroral administration
|
Mus musculus
|
48.0
%
|
|
Compound was tested for antiarthritic activity in murine model of antigen-induced arthritis upon 100 mg/kg peroral administration
|
Mus musculus
|
42.0
%
|
|
Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 10 mg/kg in the injected paw
|
Rattus norvegicus
|
38.0
%
|
|
Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 15 mg/kg in the injected paw
|
Rattus norvegicus
|
33.0
%
|
|
Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 15 mg/kg in the non-injected paw
|
Rattus norvegicus
|
70.0
%
|
|
Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 30 mg/kg in the injected paw
|
Rattus norvegicus
|
36.0
%
|
|
Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 30 mg/kg in the non-injected paw
|
Rattus norvegicus
|
54.0
%
|
|
Inhibition of rat adjuvant induced polyarthritis (AIP) at the dose of 5 mg/kg in the injected paw
|
Rattus norvegicus
|
21.0
%
|
|
Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assay
|
Escherichia coli
|
3.0
nM
|
|
Inhibition of conjugate DNA transfer between tetracycline-resistant F plasmid positive Escherichia coli JS10 to streptomycin-resistant F plasmid deficient Escherichia coli JS4
|
Escherichia coli
|
110.0
nM
|
|
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy
|
Homo sapiens
|
5.6
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in injected paw at 50 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
35.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in injected paw at 30 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
34.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in injected paw at 20 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
28.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in injected paw at 10 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
23.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in non-injected paw at 50 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
68.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in non-injected paw at 30 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
62.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in non-injected paw at 20 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
70.0
%
|
|
Antiarthritic activity in complete Freund's adjuvant-induced rat arthritis model assessed as reduction of paw volume in non-injected paw at 10 mg/kg, sc qd for 28 days
|
Rattus norvegicus
|
56.0
%
|
|
Antiinflammatory activity in methylated bovine serum albumin sensitized delayed-type hypersensitivity granuloma mouse model assessed as reduction of granuloma dry weight at 100 mg/kg, sc qd for 9 days
|
Mus musculus
|
48.0
%
|
|
Antiinflammatory activity in methylated bovine serum albumin sensitized delayed-type hypersensitivity granuloma mouse model assessed as reduction of granuloma dry weight at 60 mg/kg, sc qd for 9 days
|
Mus musculus
|
44.0
%
|
|
Antiinflammatory activity in methylated bovine serum albumin sensitized delayed-type hypersensitivity granuloma mouse model assessed as reduction of granuloma dry weight at 25 mg/kg, sc qd for 9 days
|
Mus musculus
|
33.0
%
|
|
Antiinflammatory activity in methylated bovine serum albumin sensitized delayed-type hypersensitivity granuloma mouse model assessed as reduction of granuloma wet weight at 100 mg/kg, sc qd for 9 days
|
Mus musculus
|
44.0
%
|
|
Antiinflammatory activity in methylated bovine serum albumin sensitized delayed-type hypersensitivity granuloma mouse model assessed as reduction of granuloma wet weight at 60 mg/kg, sc qd for 9 days
|
Mus musculus
|
40.0
%
|
|
Antiinflammatory activity in methylated bovine serum albumin sensitized delayed-type hypersensitivity granuloma mouse model assessed as reduction of granuloma wet weight at 25 mg/kg, sc qd for 9 days
|
Mus musculus
|
30.0
%
|
|