EcoDrugPlus


Synonyms	Alimix Cisapride Cisapride monohydrate Prepulsid Prepulsid quicklet Propulsid Propulsid quicksolv R-51,619 R-51619
Status
Molecule Category	Free-form
ATC	A03FA02
UNII	UVL329170W
EPA CompTox	DTXSID3022825

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Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	DCSUBABJRXZOMT-UHFFFAOYSA-N
Smiles	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
InChI	InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H29ClFN3O4
Molecular Weight	465.95
AlogP	3.36
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	9.0
Polar Surface Area	86.05
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	32.0

Mechanism of Action	Action	Reference
Serotonin 4 (5-HT4) receptor agonist	AGONIST	DailyMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor	-	900	63.1-316.23	94.7-152	-
Ion channel Other ion channel Pore-forming toxins (proteins and peptides)	-	-	-	-	10.6
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	6.457-150	-	-	65.5-100
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	30-110	-	30-30	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	227-680	-	227-227	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	54.7-100	6.1-9.8	-	6.1-794.33	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	100	-	1-63.1	14.3-20	98.1
Homo sapiens	79.43	6.457-227	-	6.31-794.33	65.5-100
Oryctolagus cuniculus	-	-	79.43-316.23	-	10.6
Rattus norvegicus	54.7-58.88	680-900	-	94.7-227	-

Target Conservation


Protein: Serotonin 4 (5-HT4) receptor Description: 5-hydroxytryptamine receptor 4 Organism : Homo sapiens Q13639 ENSG00000164270

Cross References

Resources	Reference
ChEBI	95129
ChEMBL	CHEMBL1729
DrugCentral	660
FDA SRS	UVL329170W
Guide to Pharmacology	240
KEGG	C06910
PharmGKB	PA449011
PubChem	6917698
SureChEMBL	SCHEMBL16131

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

CISAPRIDE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References