CC-115


InChI Key	GMYLVKUGJMYTFB-UHFFFAOYSA-N
Smiles	CCN1C(=O)CNc2ncc(-c3ccc(-c4nc[nH]n4)nc3C)nc21
InChI	InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)

Mechanism of Action	Action	Reference
DNA-dependent protein kinase inhibitor	INHIBITOR	PubMed
Serine/threonine-protein kinase mTOR inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family Atypical protein kinase FRAP subfamily	-	21-23	-	-	-
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family	-	21-23	-	-	50
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	-	-	-	57
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A	-	630	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B	-	630	-	-	-
Enzyme Transferase	-	850	-	-	-
Unclassified protein	-	23	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	15-850	-	-	50-57
Mus musculus	-	-	-	-	0-94


Protein: Serine/threonine-protein kinase mTOR Description: Serine/threonine-protein kinase mTOR Organism : Homo sapiens P42345 ENSG00000198793













Protein: DNA-dependent protein kinase Description: DNA-dependent protein kinase catalytic subunit Organism : Homo sapiens P78527 ENSG00000253729

CONTENTS