Synonyms | |
Status | |
Molecule Category | Free-form |
UNII | UM3821998K |
EPA CompTox | DTXSID40213778 |
InChI Key | OXKRFEWMSWPKKV-GHTZIAJQSA-N | |
---|---|---|
Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C22H23N3O2 | |
Molecular Weight | 361.45 | |
AlogP | 3.26 | |
Hydrogen Bond Acceptor | 4.0 | |
Hydrogen Bond Donor | 1.0 | |
Number of Rotational Bond | 4.0 | |
Polar Surface Area | 58.37 | |
Molecular species | NEUTRAL | |
Aromatic Rings | 3.0 | |
Heavy Atoms | 27.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
Neuronal acetylcholine receptor protein alpha-7 subunit agonist | AGONIST | PubMed PubMed |
Protein: Neuronal acetylcholine receptor protein alpha-7 subunit Description: Neuronal acetylcholine receptor subunit alpha-7 Organism : Homo sapiens P36544 ENSG00000175344 |
||||
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | ||
---|---|---|---|---|---|---|---|
Ion channel
Ligand-gated ion channel
5HT3 receptor
|
- | - | - | - | 25-25 | ||
Ion channel
Ligand-gated ion channel
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptor alpha subunit
|
17 | - | - | 1-3 | - | ||
Ion channel
Ligand-gated ion channel
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptor beta subunit
|
- | - | - | 1700 | - | ||
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 54000 | - | - | - | ||
Unclassified protein
|
- | - | 20 | 15 | - |
Resources | Reference | |
---|---|---|
ChEMBL | CHEMBL1258006 | |
DrugBank | DB06090 | |
FDA SRS | UM3821998K | |
Guide to Pharmacology | 3969 | |
PubChem | 25147644 | |
SureChEMBL | SCHEMBL372929 | |
ZINC | ZINC000064540331 |