ZOLMITRIPTAN


Trade Names	ZOLMITRIPTAN ZOMIG ZOMIG-ZMT
Synonyms	311-C-90 311C90 Cvt-427 NSC-760383 Zolmitriptan Zomig Zomig-zmt
Status
Molecule Category	Free-form
ATC	N02CC03
UNII	2FS66TH3YW
EPA CompTox	DTXSID8045933


InChI Key	ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Smiles	CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12
InChI	InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1

Mechanism of Action	Action	Reference
Serotonin 1b (5-HT1b) receptor agonist	AGONIST	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	13.55
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	-	7	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	-	0.04-0.3	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	15.7	2.818-6.166	1.5-1.8	0.76-124	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	95.98-102.48

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	95.98-102.48
Homo sapiens	40	-	-	78.6	13.55


Protein: Serotonin 1d (5-HT1d) receptor Description: 5-hydroxytryptamine receptor 1D Organism : Homo sapiens P28221 ENSG00000179546








Protein: Serotonin 1b (5-HT1b) receptor Description: 5-hydroxytryptamine receptor 1B Organism : Homo sapiens P28222 ENSG00000135312

CONTENTS