EcoDrugPlus


Trade Names	REMODULIN TREPROSTINIL TYVASO
Synonyms	15-AU-81 15AU81 L-606 LRX -15 LRX-15 Remodulin Rumodolin Treprostinil Tresprostinil Tyvaso UT-15 Uniprost
Status
Molecule Category	Free-form
ATC	B01AC21
UNII	RUM6K67ESG

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Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	PAJMKGZZBBTTOY-ZFORQUDYSA-N
Smiles	CCCCC[C@H](O)CC[C@@H]1[C@H]2Cc3cccc(OCC(=O)O)c3C[C@H]2C[C@H]1O
InChI	InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H34O5
Molecular Weight	390.52
AlogP	3.58
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	10.0
Polar Surface Area	86.99
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	28.0

Mechanism of Action	Action	Reference
Prostanoid IP receptor agonist	AGONIST	PubMed

Target Conservation


Protein: Prostanoid IP receptor Description: Prostacyclin receptor Organism : Homo sapiens P43119 ENSG00000160013

Cross References

Resources	Reference
ChEBI	50861
ChEMBL	CHEMBL1237119
DrugBank	DB00374
DrugCentral	2720
FDA SRS	RUM6K67ESG
Human Metabolome Database	HMDB0014518
Guide to Pharmacology	5820
PubChem	6918140
SureChEMBL	SCHEMBL4349618
ZINC	ZINC000003800475

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TREPROSTINIL

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References