SULFASALAZINE


Trade Names	AZULFIDINE AZULFIDINE EN-TABS S.A.S.-500 SULFASALAZINE
Synonyms	Azulfidine Azulfidine EN Azulfidine en-tabs Benzosulfa Colizine NSC-203730 NSC-667219 S.a.s. S.a.s.-500 SAS-500 Salazopyrin Salazopyrin e.c. Salazopyrin-en Salazosulfapyridine Salicylazosulfapyridine
Status
Molecule Category	Free-form
ATC	A07EC01
UNII	3XC8GUZ6CB
EPA CompTox	DTXSID0021256


InChI Key	NCEXYHBECQHGNR-QZQOTICOSA-N
Smiles	O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O
InChI	InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

Mechanism of Action	Action	Reference
Arachidonate 5-lipoxygenase inhibitor	INHIBITOR	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	37.6
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase SGK family	-	-	-	-	70
Enzyme Oxidoreductase	-	-	436.52-440	-	60
Enzyme Transferase	-	-	-	-	0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) SLC07 Cationic amino acid transporter/glycoprotein-associated family	-	160	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	560	-	530	72.1-126.2
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	916	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	72.91-126.2
Homo sapiens	916	160-900	436.52-440	530	-3.7-92.3
Mus musculus	-	-	-	-	30.59-55.17
Rattus norvegicus	-	-	-	-	16-73
Trypanosoma cruzi	-	-	-	-	37.6


Protein: Arachidonate 5-lipoxygenase Description: Polyunsaturated fatty acid 5-lipoxygenase Organism : Homo sapiens P09917 ENSG00000012779












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

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