PROCHLORPERAZINE EDISYLATE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII PG20W5VQZS
EPA CompTox DTXSID4074483
Parent Compound: PROCHLORPERAZINE

Structure

InChI Key SWOUGRBFXFILIB-UHFFFAOYSA-N
Smiles CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.O=S(=O)(O)CCS(=O)(=O)O
InChI
InChI=1S/C20H24ClN3S.C2H6O6S2/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;3-9(4,5)1-2-10(6,7)8/h2-3,5-8,15H,4,9-14H2,1H3;1-2H2,(H,3,4,5)(H,6,7,8)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H30ClN3O6S3
Molecular Weight 564.15
AlogP 4.58
Hydrogen Bond Acceptor 4.0
Number of Rotational Bond 4.0
Polar Surface Area 9.72
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Mechanism of Action Action Reference
Dopamine D2 receptor antagonist ANTAGONIST FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 110.92-115.21
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 110.92-115.21

Target Conservation

Protein: Dopamine D2 receptor
Description: D(2) dopamine receptor
Organism : Homo sapiens
P14416 ENSG00000149295

Cross References

Resources Reference
ChEMBL CHEMBL1201154
FDA SRS PG20W5VQZS
PubChem 91499
SureChEMBL SCHEMBL40855
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