EcoDrugPlus


Trade Names	POMALYST
Synonyms	Actimid CC-4047 IMID 3 IMID-3 Imnovid Pomalidomide Pomalyst
Status
Molecule Category	Free-form
ATC	L04AX06
UNII	D2UX06XLB5
EPA CompTox	DTXSID40893458


InChI Key	UVSMNLNDYGZFPF-UHFFFAOYSA-N
Smiles	Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChI	InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

Property Name	Value
Molecular Formula	C13H11N3O4
Molecular Weight	273.25
AlogP	-0.33
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	109.57
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	20.0

Mechanism of Action	Action	Reference
CRL4(CRBN) E3 ubiquitin ligase inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Unclassified protein	22-24	-	-	800	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	8-27	13-230	157	-	21-95
Magnetospirillum gryphiswaldense	-	-	-	800	-
Rattus norvegicus	-	-	-	-	5.5

Resources	Reference
ChEBI	72690
ChEMBL	CHEMBL43452
DrugBank	DB08910
DrugCentral	4746
FDA SRS	D2UX06XLB5
Guide to Pharmacology	7348
PubChem	134780
SureChEMBL	SCHEMBL19250920

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

POMALIDOMIDE

Structure

Physicochemical Descriptors

Pharmacology

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