EcoDrugPlus


Trade Names	PINDOLOL VISKEN
Synonyms	(rs)-pindolol Apo-pindol Betadren Betapindol Blocklin-l Calvisken Carvisken Decreten Dl-lb-46 Dl-pindolol Durapindol Glauco-visken LB-46 NSC-757276 Pectobloc
Status
Molecule Category	Free-form
ATC	C07AA03
UNII	BJ4HF6IU1D
EPA CompTox	DTXSID8023476

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Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	JZQKKSLKJUAGIC-UHFFFAOYSA-N
Smiles	CC(C)NCC(O)COc1cccc2[nH]ccc12
InChI	InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H20N2O2
Molecular Weight	248.33
AlogP	1.91
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	57.28
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Beta-1 adrenergic receptor partial agonist	PARTIAL AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	-	0.537-165.96	0.4-0.52	84
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	27	-	63.1	20-110	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-24.7-97.58

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	85.04-97.58
Homo sapiens	27	-	0.537-165.96	0.4-110	-24.7-24.5
Rattus norvegicus	-	-	-	1-1	84

Target Conservation


Protein: Beta-2 adrenergic receptor Description: Beta-2 adrenergic receptor Organism : Homo sapiens P07550 ENSG00000169252












Protein: Beta-1 adrenergic receptor Description: Beta-1 adrenergic receptor Organism : Homo sapiens P08588 ENSG00000043591

Cross References

Resources	Reference
ChEBI	8214
ChEMBL	CHEMBL500
DrugBank	DB00960
DrugCentral	2176
FDA SRS	BJ4HF6IU1D
Human Metabolome Database	HMDB0015095
Guide to Pharmacology	91
KEGG	C07445
PharmGKB	PA450966
PubChem	4828
SureChEMBL	SCHEMBL5219
ZINC	ZINC00056646

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PINDOLOL

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References