OFLOXACIN


Trade Names	FLOXIN FLOXIN IN DEXTROSE 5% FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER FLOXIN OTIC OCUFLOX OFLOXACIN
Synonyms	DL-8280 Exocin Floxin Floxin otic HOE 280 HOE-280 J01MA01 NSC-727071 NSC-758178 Ocuflox Ofloxacin Tarivid Tarivid 400 Tarivid i.v. Visiren
Status
Molecule Category	Free-form
ATC	J01MA01 S01AE01 S02AA16
UNII	A4P49JAZ9H
EPA CompTox	DTXSID3041085


InChI Key	GSDSWSVVBLHKDQ-UHFFFAOYSA-N
Smiles	CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
InChI	InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)

Property Name	Value
Molecular Formula	C18H20FN3O4
Molecular Weight	361.37
AlogP	1.54
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	75.01
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
Bacterial DNA gyrase inhibitor	INHIBITOR	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-8.2-89.51
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	21.1

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Chlamydia trachomatis	-	666	-	-	-
Cricetulus griseus	-	-	-	-	65.85-89.51
Homo sapiens	-	-	-	-	-8.2-24.5

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia

Resources	Reference
ChEBI	7731
ChEMBL	CHEMBL4
DrugBank	DB01165
DrugCentral	1981
FDA SRS	A4P49JAZ9H
Human Metabolome Database	HMDB0015296
Guide to Pharmacology	10918
KEGG	C07321
PDB	LFX
PharmGKB	PA450684
PubChem	4583
SureChEMBL	SCHEMBL24373
ZINC	ZINC00538273

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

OFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Environmental Exposure

Cross References