|
Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity)
|
None
|
500.0
ug.mL-1
|
|
|
Concentration of compound needed to produce linear DNA at an intensity relative to oxolinic acid at 10 ug/mL was measured on Escherichia coli for gyrase-drug induced cleavage,.
|
Escherichia coli
|
5.5
ug.mL-1
|
|
|
Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M
|
None
|
20.0
nM
|
|
|
Inhibitory concentration in supercoiling inhibition Escherichia coli DNA gyrase assay
|
Escherichia coli
|
5.5
ug.mL-1
|
|
|
Supercoiling inhibition activity DNA gyrase isolated from Escherichia coli H560
|
Escherichia coli
|
1.0
ug.mL-1
|
|
|
Inhibition constant against DNA Gyrase isolated from Escherichia coli
|
Escherichia coli
|
1.0
ug ml-1
|
|
|
Inhibition constant against DNA Gyrase isolated from Micrococcus luteus
|
Micrococcus luteus
|
72.0
ug ml-1
|
|
|
Inhibition of DNA gyrase supercoiling in Escherichia coli ATCC 25922
|
Escherichia coli
|
600.0
nM
|
|
|
Inhibition of Escherichia coli H560 DNA gyrase
|
Escherichia coli
|
1.0
ug.mL-1
|
|
|
Antibacterial activity against Escherichia coli at 100 ug/mL after 48 hrs by cup-plate method
|
Escherichia coli
|
100.0
%
|
|
|
Antibacterial activity against Escherichia coli at 50 ug/mL after 48 hrs by cup-plate method
|
Escherichia coli
|
220.0
%
|
|
|
Antibacterial activity against Escherichia coli at 25 ug/mL after 48 hrs by cup-plate method
|
Escherichia coli
|
100.0
%
|
|
|
Antibacterial activity against Bacillus cirrhosis at 100 ug/mL after 48 hrs by cup-plate method
|
Bacillus
|
100.0
%
|
|
|
Antibacterial activity against Bacillus cirrhosis at 50 ug/mL after 48 hrs by cup-plate method
|
Bacillus
|
100.0
%
|
|
|
Antibacterial activity against Bacillus cirrhosis at 25 ug/mL after 48 hrs by cup-plate method
|
Bacillus
|
100.0
%
|
|
|
Antifungal activity against Aspergillus niger at 100 ug/mL after 48 hrs by cup-plate method
|
Aspergillus niger
|
100.0
%
|
|
|
Antifungal activity against Aspergillus niger at 50 ug/mL after 48 hrs by cup-plate method
|
Aspergillus niger
|
100.0
%
|
|
|
Antifungal activity against Aspergillus niger at 25 ug/mL after 48 hrs by cup-plate method
|
Aspergillus niger
|
100.0
%
|
|
|
Antifungal activity against Rhizoctonia bataticola at 100 ug/mL after 48 hrs by cup-plate method
|
Rhizoctonia bataticola
|
100.0
%
|
|
|
Antifungal activity against Rhizoctonia bataticola at 50 ug/mL after 48 hrs by cup-plate method
|
Rhizoctonia bataticola
|
100.0
%
|
|
|
Antifungal activity against Rhizoctonia bataticola at 25 ug/mL after 48 hrs by cup-plate method
|
Rhizoctonia bataticola
|
100.0
%
|
|
|
Inhibition of Escherichia coli DNA gyraseB assessed as inhibition of pBR322 supercoiling by densitometry
|
Escherichia coli
|
90.0
nM
|
|
Inhibition of Escherichia coli DNA gyraseB assessed as inhibition of pBR322 supercoiling by densitometry
|
Escherichia coli
|
0.09
nM
|
|
|
PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhimurium using a modified counterscreen. (Class of assay: confirmatory) [Related pubchem assays: 2253, 1863, 1874 ]
|
None
|
890.0
nM
|
|
|
PUBCHEM_BIOASSAY: A Counter Screen to identiry small molecule screen for inhibitors of the PhoP region in Salmonella Typhimurium. (Class of assay: confirmatory) [Related pubchem assays: 2253, 1863, 1981, 1874 ]
|
None
|
880.0
nM
|
|
|
PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in Salmonella Typhimurium. (Class of assay: confirmatory) [Related pubchem assays: 2253, 1981, 1874 ]
|
None
|
510.0
nM
|
|
|
PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of the PhoP region in Salmonella typhi. (Class of assay: confirmatory) [Related pubchem assays: 1850, 1864, 2252, 1985 ]
|
None
|
490.0
nM
|
|
|
PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in Salmonella typhi. (Class of assay: confirmatory) [Related pubchem assays: 1864, 2252, 1985 ]
|
None
|
270.0
nM
|
|
|
PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi using a modified counterscreen. (Class of assay: confirmatory)
|
None
|
230.0
nM
|
|
|
Inhibition of Escherichia coli DNA gyrase assessed as inhibition of pBR322 supercoiling by densitometry
|
Escherichia coli
|
90.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis
|
Mycobacterium tuberculosis
|
8.0
ug.mL-1
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
97.94
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
99.94
%
|
|
|
Antibacterial activity against Bacillus amyloliquefaciens at 25 ug/ml after overnight incubation by plate colony counting method relative to control
|
Bacillus amyloliquefaciens
|
89.0
%
|
|
|
Antibacterial activity against Staphylococcus aureus at 25 ug/ml after overnight incubation by plate colony counting method relative to control
|
Staphylococcus aureus
|
86.0
%
|
|
|
Antibacterial activity against Bacillus subtilis at 25 ug/ml after overnight incubation by plate colony counting method relative to control
|
Bacillus subtilis
|
85.0
%
|
|
|
Antibacterial activity against Bacillus amyloliquefaciens at 25 ug/ml after 24 hrs by plate colony counting method relative to control
|
Bacillus amyloliquefaciens
|
84.0
%
|
|
|
Antibacterial activity against Staphylococcus aureus at 25 ug/ml after 24 hrs by plate colony counting method relative to control
|
Staphylococcus aureus
|
78.0
%
|
|
|
Antibacterial activity against Bacillus subtilis at 25 ug/ml after 24 hrs by plate colony counting method relative to control
|
Bacillus subtilis
|
89.0
%
|
|
|
Antibacterial activity against Bacillus subtilis MTCC 441 by broth microdilution method
|
Bacillus subtilis
|
100.0
ug.mL-1
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
6.88
%
|
|
|
Antibacterial activity against Escherichia coli ATCC 8739 incubated for 24 hrs by resazurin dye based fluorimetric assay
|
Escherichia coli
|
250.0
nM
|
|
|
Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 incubated for 24 hrs by resazurin dye based fluorimetric assay
|
Pseudomonas aeruginosa
|
500.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
34.2
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
21.69
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.15
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.08
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.15
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.08
%
|
|
|
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
|
Homo sapiens
|
302.0
nM
|
|
|
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
|
Homo sapiens
|
302.0
nM
|
|
