EcoDrugPlus


Trade Names	EC-NAPROSYN NAPROSYN NAPROXEN
Synonyms	Aleve Anaprox Arthrosin 250 Arthrosin 250 ec Arthrosin 500 Arthrosin 500 ec Condrotec Ec-naprosyn Equiproxen Feminax ultra Grenoxal Kenosyn Laraflex NSC-750183 NSC-757239
Status
Molecule Category	Free-form
ATC	G02CC02 M01AE02 M02AA12
UNII	57Y76R9ATQ
EPA CompTox	DTXSID4040686

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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Similarity

SubStructure


InChI Key	CMWTZPSULFXXJA-VIFPVBQESA-N
Smiles	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
InChI	InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H14O3
Molecular Weight	230.26
AlogP	3.04
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	46.53
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	17.0

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	64
Enzyme Oxidoreductase	-	60-900	-	-	30-88
Enzyme Protease Aspartic protease Aspartic protease AD clan Aspartic protease A22A subfamily Aspartic protease A22A regulatory subfamily	-	-	-	-	3
Enzyme	-	60-900	-	-	30-88
Ion channel Other ion channel Miscellaneous ion channel Presenilin ER Ca2+ leak channel family	-	-	-	-	3
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor	-	-	-	-	35
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	103.46-114.77

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	-	-	-	30
Cavia porcellus	-	-	-	-	60
Cochliobolus lunatus	-	-	-	-	9
Cricetulus griseus	-	-	-	-	103.46-114.77
Homo sapiens	-	180-900	-	-	3-88
Mus musculus	-	200-330	-	-	18-66.9
Oryctolagus cuniculus	-	-	-	-	55
Ovis aries	-	61-180	-	-	46-72
Rattus norvegicus	-	-	-	-	9.4-85.02
influenza A virus	-	-	-	250	-

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Environmental Exposure

Countries
Croatia
Czech Republic
Germany
Hungary
India
Romania
Serbia
Slovakia
Slovenia
South Africa
Sweden

Cross References

Resources	Reference
ChEBI	7476
ChEMBL	CHEMBL154
DrugBank	DB00788
DrugCentral	1883
FDA SRS	57Y76R9ATQ
Human Metabolome Database	HMDB0001923
Guide to Pharmacology	5230
PDB	NPS
PubChem	156391
SureChEMBL	SCHEMBL3046
ZINC	ZINC000000105216


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

NAPROXEN

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Environmental Exposure

Cross References