MEROPENEM


Trade Names	MEROPENEM MEROPENEM AND SODIUM CHLORIDE IN DUPLEX CONTAINER MERREM
Synonyms	ICI 194,660 ICI-194660 Meronem Meropenem Meropenem (as trihydrate) Meropenem anhydrous Meropenem hydrate Meropenem trihydrate Meropenem, anhydrous Merrem Merrem i.v. Merrem iv NSC-759621 SM-7338
Status
Molecule Category	Free-form
ATC	J01DH02
UNII	YOP6PX0BAO
EPA CompTox	DTXSID7045526


InChI Key	DMJNNHOOLUXYBV-PQTSNVLCSA-N
Smiles	C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)N(C)C)C3)[C@H](C)[C@H]12
InChI	InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1

Property Name	Value
Molecular Formula	C17H25N3O5S
Molecular Weight	383.47
AlogP	-0.31
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	110.18
Molecular species	ZWITTERION
Aromatic Rings	0.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
Bacterial penicillin-binding protein inhibitor	INHIBITOR	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	850	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Escherichia coli	-	10	-	-	-
Klebsiella pneumoniae	-	-	850	-	-
Pseudomonas aeruginosa	-	20	-	-	-
Staphylococcus aureus	-	10	-	-	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	43968
ChEMBL	CHEMBL127
DrugBank	DB00760
DrugCentral	1709
FDA SRS	YOP6PX0BAO
Human Metabolome Database	HMDB0014898
Guide to Pharmacology	10829
PDB	MEM
PubChem	441129
SureChEMBL	SCHEMBL34442
ZINC	ZINC000003808779

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

MEROPENEM

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References