MEDROXYPROGESTERONE ACETATE

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Trade Names
Synonyms
Status
Molecule Category Free-form
UNII C2QI4IOI2G
EPA CompTox DTXSID0025527
Parent Compound:

Structure

InChI Key PSGAAPLEWMOORI-PEINSRQWSA-N
Smiles CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
InChI
InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H34O4
Molecular Weight 386.53
AlogP 4.66
Hydrogen Bond Acceptor 4.0
Number of Rotational Bond 2.0
Polar Surface Area 60.44
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 28.0

Pharmacology

Mechanism of Action Action Reference
Progesterone receptor agonist AGONIST DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme
- 300 - - -
Secreted protein
- - 630.96 - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A Nuclear hormone receptor subfamily 3 group A member 1
924 924-924 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A Nuclear hormone receptor subfamily 3 group A member 2
924 924-924 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 1
10-10 10-10 - 13.2-13.2 -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 3
0.1-0.5 10.8-10.8 - 0.3388-1.4 -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
6.1-6.1 6.1-794.33 - 2.9-2.9 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 104.39-105.87
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 104.39-105.87
Homo sapiens
157 6.1-924 630.96 0.3388-13.2 -
Mus musculus
159 - - - -
Rattus norvegicus
- 35.48-794.33 - - -

Target Conservation

Protein: Progesterone receptor
Description: Progesterone receptor
Organism : Homo sapiens
P06401 ENSG00000082175

Cross References

Resources Reference
ChEBI 6716
ChEMBL CHEMBL717
DrugBank DB00603
DrugCentral 1659
FDA SRS C2QI4IOI2G
KEGG C08150
PubChem 6279
SureChEMBL SCHEMBL4276
ZINC ZINC000005029557
CONTENTS