MAZINDOL

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Search structure


Trade Names	MAZANOR SANOREX
Synonyms	42-548 AN-448 Magrilon Mazanor Mazildene Mazindol Mazindol civ SAH-42548 Sanorex Terenac Teronac
Status
Molecule Category	Free-form
ATC	A08AA05
UNII	C56709M5NH
EPA CompTox	DTXSID1023237

Structure


InChI Key	ZPXSCAKFGYXMGA-UHFFFAOYSA-N
Smiles	OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCN21
InChI	InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H13ClN2O
Molecular Weight	284.75
AlogP	2.61
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	1.0
Polar Surface Area	35.83
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	20.0

Pharmacology

Mechanism of Action	Action	Reference
Monoamine transporter inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor	-	234.42	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	0.92-290	8.63	0.8-404	22.1-60

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	42.6-42.6	-	-	-
Homo sapiens	-	0.92-94	-	11.3-136	22.1
Mus musculus	-	13	-	404	-

Cross References

Resources	Reference
ChEBI	6702
ChEMBL	CHEMBL781
DrugBank	DB00579
DrugCentral	1640
FDA SRS	C56709M5NH
Human Metabolome Database	HMDB0014718
Guide to Pharmacology	4591
KEGG	D00367
PharmGKB	PA450326
PubChem	4020
SureChEMBL	SCHEMBL27849
ZINC	ZINC00896621

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025