LORLATINIB


InChI Key	IIXWYSCJSQVBQM-LLVKDONJSA-N
Smiles	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21
InChI	InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

Mechanism of Action	Action	Reference
ALK tyrosine kinase receptor inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ack family	-	17	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Alk family	-	2.7	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Fak family	-	14-17	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Fer family	-	3.3-6	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Sev family	-	0.19-0.23	-	0.1-12	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	53	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Trk family	-	24-46	-	23-23	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase STKR family TKL protein kinase STKR Type 1 subfamily	-	0.2-77	-	0.7-8.2	-
Surface antigen	-	0.23	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC34 family of sodium phosphate co-transporters	-	0.19	-	-	-
Unclassified protein	-	0.2-77	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.19-357	-	0.1-23	-
Mus musculus	-	1.2-262	-	-	-


Protein: EML4-ALK Description: Echinoderm microtubule-associated protein-like 4 Organism : Homo sapiens Q9HC35 ENSG00000143924











Protein: ALK tyrosine kinase receptor Description: ALK tyrosine kinase receptor Organism : Homo sapiens Q9UM73 ENSG00000171094











Protein: EML4-ALK Description: ALK tyrosine kinase receptor Organism : Homo sapiens Q9UM73 ENSG00000171094

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