LIOTHYRONINE SODIUM

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Search structure


Trade Names	CYTOMEL LIOTHYRONINE SODIUM TRIOSTAT
Synonyms	Basoprocin Cynomel Cytobin Cytomel Ibiothyron L-triiodothyronine hydrochloride L-triiodothyronine sodium salt Liothyronine hydrochloride Liothyronine sodium Liothyronine sodium salt Liotrix (t3) Lyothyronin NSC-758175 NSC-80774 Rathyronine hydrochloride, (s)-
Status
Molecule Category	Salt-form
ATC	H03AA02
UNII	GCA9VV7D2N
EPA CompTox	DTXSID8047505
Parent Compound:	LIOTHYRONINE

Structure


InChI Key	SBXXSUDPJJJJLC-YDALLXLXSA-M
Smiles	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)[O-].[Na+]
InChI	InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H11I3NNaO4
Molecular Weight	672.96
AlogP	3.95
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	92.78
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	23.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action	Action	Reference
Thyroid hormone receptor agonist	AGONIST	DailyMed Wikipedia Wikipedia

Cross References

Resources	Reference
ChEBI	6484
ChEMBL	CHEMBL1201119
FDA SRS	GCA9VV7D2N
PubChem	23666110
SureChEMBL	SCHEMBL41654

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025