INDAPAMIDE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC C03BA11
UNII F089I0511L
EPA CompTox DTXSID7044633

Structure

InChI Key NDDAHWYSQHTHNT-UHFFFAOYSA-N
Smiles CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1
InChI
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H16ClN3O3S
Molecular Weight 365.84
AlogP 2.08
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 92.5
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Mechanism of Action Action Reference
Thiazide-sensitive sodium-chloride cotransporter inhibitor INHIBITOR ISBN Wikipedia Wikipedia FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Lyase
- - 0.33-710 0.23-890 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 80.06-97.5
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 80.06-97.5
Homo sapiens
- - 0.33-710 0.23-890 -
Mus musculus
- - - 13 -

Cross References

Resources Reference
ChEBI 5893
ChEMBL CHEMBL406
DrugBank DB00808
DrugCentral 1433
FDA SRS F089I0511L
Human Metabolome Database HMDB0014946
Guide to Pharmacology 7203
KEGG D00345
PDB BL1
PharmGKB PA449975
PubChem 3702
SureChEMBL SCHEMBL41303
ZINC ZINC00643114
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