GLYCINE

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Trade Names
Synonyms
Status
Molecule Category UNKNOWN
ATC B05CX03
UNII TE7660XO1C
EPA CompTox DTXSID9020667

Structure

InChI Key DHMQDGOQFOQNFH-UHFFFAOYSA-N
Smiles NCC(=O)O
InChI
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

Physicochemical Descriptors

Property Name Value
Molecular Formula C2H5NO2
Molecular Weight 75.07
AlogP -0.97
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 63.32
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 5.0
Assay Description Organism Bioactivity Reference
In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor None 250.0 nM
Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]glycine as the radioligand. None 86.0 nM
Affinity for the glycine binding site of NMDA receptor by inhibition of [3H]5,7-dichlorokynurenic acid ([3H]DCKA) binding to rat brain synaptic membrane None 170.0 nM
Binding affinity against glycine binding site associated with N-methyl-D-aspartate glutamate receptor of rat synaptic plasma membrane(SPM) determined using [3H]glycine as radioligand. None 690.0 nM
Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor None 200.0 nM
In vitro concentration eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor None 68.0 nM
In vitro inhibition of [3H]glycine at NMDA receptor None 200.0 nM
Effective concentration against NR1/NR2A receptor None 840.0 nM
Effective concentration against NR1/NR2B receptor None 190.0 nM
Effective concentration against NR1/NR2C receptor None 150.0 nM
Effective concentration against NR1/NR2D receptor None 96.0 nM
Displacement of [3H]glycine from strychnine-insensitive glycine recognition site of NMDA receptor in rat brain cortex membrane Rattus norvegicus 125.89 nM
Inhibition of rat glutamate receptor Rattus norvegicus 223.0 nM
Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cells at 1 mM Mus musculus 83.1 %
Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells at 1 mM Mus musculus 60.7 %
Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells at 1 mM Mus musculus 49.3 %
Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in human HEK cells at 1 mM Mus musculus 69.7 %
Inhibition of ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes at 1 mM after 5 mins by beta counting analysis Rattus norvegicus 25.0 %
Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake at 200 uM preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH Homo sapiens 33.0 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Homo sapiens -2.42 %
Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay Homo sapiens 58.0 nM
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 11.23 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.07 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.07 %
Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake at 200 uM by scintillation counting cis-inhibition assay Homo sapiens 33.0 %
Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 990.0 nM
Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 240.0 nM
Agonist activity at rat GluN1/GluN2C NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 210.0 nM
Agonist activity at rat GluN1/GluN2D NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay Rattus norvegicus 91.0 nM

Cross References

Resources Reference
ChEBI 57305
ChEMBL CHEMBL773
DrugBank DB00145
DrugCentral 1319
FDA SRS TE7660XO1C
Human Metabolome Database HMDB0000123
Guide to Pharmacology 4084
KEGG C00037
PDB GLY
PharmGKB PA449789
PubChem 750
SureChEMBL SCHEMBL6163
ZINC ZINC000004658552
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