GLYBURIDE

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Trade Names
Synonyms
Status
Molecule Category Free-form
UNII SX6K58TVWC
EPA CompTox DTXSID0037237

Structure

InChI Key ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Smiles COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1
InChI
InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H28ClN3O5S
Molecular Weight 494.01
AlogP 3.64
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 8.0
Polar Surface Area 113.6
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 33.0

Pharmacology

Mechanism of Action Action Reference
Sulfonylurea receptor 1, Kir6.2 blocker BLOCKER Wikipedia FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Other ion channel Pore-forming toxins (proteins and peptides)
- - - - 35
Ion channel Voltage-gated ion channel Potassium channels Inwardly rectifying potassium channel
- 4.3-220 - 130 0-92.7
Ion channel Voltage-gated ion channel Potassium channels Two-pore domain potassium channel
- - - - 3.6
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 2
- - - - 21.5
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3
- - - 660 77.5
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 49.3-92.4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 0.3
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
- 4.3-220 - 130 0-92.7
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Canis lupus familiaris
- - - 130 -
Cavia porcellus
- 8 - - 0-87
Cricetulus griseus
- - - - 59.94-72.34
Homo sapiens
- 4.3-220 - 660 0.3-92.7
Mesocricetus auratus
- 5.7 - 0.65 10
Mus musculus
- - - - 13.6-60.92
Oryctolagus cuniculus
- - - - 35
Rattus norvegicus
3-7 1.1-14.24 - 0.608 11-52

Target Conservation

Protein: Sulfonylurea receptor 1, Kir6.2
Description: ATP-binding cassette sub-family C member 8
Organism : Homo sapiens
Q09428 ENSG00000006071
Protein: Sulfonylurea receptor 1, Kir6.2
Description: ATP-sensitive inward rectifier potassium channel 11
Organism : Homo sapiens
Q14654 ENSG00000187486

Cross References

Resources Reference
ChEBI 5441
ChEMBL CHEMBL472
DrugBank DB01016
DrugCentral 1314
FDA SRS SX6K58TVWC
Human Metabolome Database HMDB0015151
Guide to Pharmacology 2414
KEGG C07022
PDB GBM
PharmGKB PA449782
PubChem 3488
SureChEMBL SCHEMBL22009
ZINC ZINC000000537805
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