None is not found in the database.

GATIFLOXACIN


Trade Names	GATIFLOXACIN ZYMAR ZYMAXID
Synonyms	AM-1155 BMS-206584-01 BMS-20658401 Gatiflo Gatifloxacin Gatifloxacin (sesquihydrate) Gatifloxacin anhydrous Gatifloxacin hydrate Gatifloxacin sesquihydrate NSC-758701 PD-135432 Tequin Zymar Zymaxid Zymer
Status
Molecule Category	Free-form
ATC	J01MA16 S01AE06
UNII	81485Y3A9A
EPA CompTox	DTXSID5045704


InChI Key	XUBOMFCQGDBHNK-UHFFFAOYSA-N
Smiles	COc1c(N2CCNC(C)C2)c(F)cc2c(=O)c(C(=O)O)cn(C3CC3)c12
InChI	InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)

Property Name	Value
Molecular Formula	C19H22FN3O4
Molecular Weight	375.4
AlogP	1.98
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	83.8
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	27.0

Mechanism of Action	Action	Reference
DNA gyrase inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Isomerase	-	500-500	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	96.61-121.89

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	96.61-121.89
Escherichia coli	-	500-500	-	-	-
Homo sapiens	-	-	-	-	-97.9-84.7

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	5280
ChEMBL	CHEMBL31
DrugBank	DB01044
DrugCentral	1280
FDA SRS	81485Y3A9A
Human Metabolome Database	HMDB0015178
Guide to Pharmacology	10816
KEGG	C07661
PharmGKB	PA449738
PubChem	5282384
SureChEMBL	SCHEMBL22591
ZINC	ZINC38197764

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

GATIFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References