Structure

InChI Key GHASVSINZRGABV-UHFFFAOYSA-N
Smiles O=c1[nH]cc(F)c(=O)[nH]1
InChI
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

Physicochemical Descriptors

Property Name Value
Molecular Formula C4H3FN2O2
Molecular Weight 130.08
AlogP -0.8
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 0.0
Polar Surface Area 65.72
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 9.0

Metabolites Network

visNetwork

Bioactivity

Mechanism of Action Action Reference
DNA inhibitor INHIBITOR PubMed
Protein: Thymidylate synthase

Description: Thymidylate synthase

Organism : Homo sapiens

P04818 ENSG00000176890
Assay Description Organism Bioactivity Reference
Inhibitory concentration of compound for cytotoxicity against A459 human lung cells was determined Homo sapiens 0.26 ug.mL-1
Tested for cytotoxicity against antigen positive 791T osteosarcoma cells having only 3-5% antigen expression Homo sapiens 0.7 ug.mL-1
In vitro inhibitory activity against Mouse melanoma (B16) cell line. Mus musculus 2.6 ug.mL-1
Tested for cytotoxicity against C170 colorectal carcinoma cell line by [75Se]selenomethionine uptake assay, in vitro Homo sapiens 0.3 ug.mL-1
Concentration at 50 percent inhibition of cell growth against human leukemia CCRF CEM cell line in vitro Homo sapiens 0.95 ug.mL-1
The compound was evaluated for antitumoral activity against human leukemia cell line CCRF CEM after 72 hr of incubation Homo sapiens 4.0 ug.mL-1
Concentration required for 50% inhibition of cell growth of CCRF CEM leukemic cell lines in human. Homo sapiens 40.0 ug.mL-1
In vitro inhibitory activity against Human T-cell acute lymphoblastoid leukemia (CCRF CEM) cell line. Homo sapiens 40.0 ug.mL-1
In vitro inhibitory activity against growth of Human acute lymphocytic leukemia (CCRF-CEM) cells Homo sapiens 2.1 ug.mL-1
In vitro inhibitory effect on growth of human T-cell acute lymphoblastoid leukemic CCRFCEM cell lines. Homo sapiens 40.0 ug.mL-1
In vitro inhibitory activity against growth of Human colon adenocarcinoma (COLO 205) cells. Homo sapiens 0.1 ug.mL-1
Evaluated for the inhibition of tumor cell growth of Human T-Lymphocyte cells (CEM/0) Homo sapiens 1.2 ug.mL-1
In vitro inhibitory activity against growth of Human epidermoid carcinoma (Calu-1) cells Homo sapiens 3.3 ug.mL-1
Evaluated for the inhibition of tumor cell growth of murine mammary carcinoma malignant tumor cell line (FM3A/0) Mus musculus 0.02 ug.mL-1
In vitro inhibitory activity against growth of Human osteogenic sarcoma (G-292) cells Homo sapiens 3.3 ug.mL-1
Inhibitory concentration of compound for cytotoxicity against HCT15 human colon cells was determined Homo sapiens 0.11 ug.mL-1
In vitro inhibitory activity against Human promyelocytic leukemia (HL-60) cell line. Homo sapiens 1.3 ug.mL-1
In vitro inhibitory activity against growth of Human promyelocytic leukemia (HL-60) cells Homo sapiens 1.33 ug.mL-1
Antitumor activity against colon carcinoma cell line (HT-29) Homo sapiens 150.0 nM
In vitro inhibitory activity against growth of Human osteogenic sarcoma (HOS) cells Homo sapiens 0.79 ug.mL-1
In vitro inhibitory activity against growth of Human bladder carcinoma (HT1376) cells Homo sapiens 0.58 ug.mL-1
In vitro inhibitory concentration for cytotoxic activity was tested against HeLa cells Homo sapiens 3.0 ug.mL-1
Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 0.1 micro g/mL of the compound Homo sapiens 19.0 %
Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 10 micro g/mL of the compound Homo sapiens 63.5 % Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 10 micro g/mL of the compound Homo sapiens 70.0 %
Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 1 micro g/mL of the compound Homo sapiens 55.0 %
Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 25 micro g/mL of the compound Homo sapiens 77.0 %
Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 50 micro g/mL of the compound Homo sapiens 90.0 %
Percent inhibition of growth of human cervical carcinoma (HeLa) cells in culture at 5 micro g/mL of the compound Homo sapiens 34.3 %
Compound was tested in vitro for cytotoxicity against HeLa cells. Homo sapiens 6.0 ug
In vitro antitumor activity in IM-9 cell lines Homo sapiens 0.34 ug.mL-1
Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 24 hr Mus musculus 220.0 nM
Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 48 hr Mus musculus 125.0 nM
Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 8 hr Mus musculus 630.0 nM
In vitro inhibitory activity against growth of Human chronic myelogenous leukemia (K562 cells Homo sapiens 2.2 ug.mL-1
In vitro inhibitory effect on growth of human chronic myelogenous leukemic K562 cell lines. Homo sapiens 38.0 ug.mL-1
In vitro inhibitory activity against growth of Human renal-cell carcinoma (KU-2) cells Homo sapiens 0.28 ug.mL-1
Concentration required for 50% inhibition of cell growth of K562 leukemic cell lines in human. Homo sapiens 3.8 ug.mL-1
In vitro inhibitory activity against Human gastric carcinoma (KATO III) cell line. Homo sapiens 3.7 ug.mL-1
Concentration required for 50% inhibition of human lung squamous cell carcinoma KATO III solid cell lines. Homo sapiens 3.7 ug.mL-1
Concentration at 50 percent inhibition of cell growth against human cancer KB cell line in vitro Homo sapiens 12.1 ug.mL-1
In vitro inhibitory activity against Human oral epidermoid carcinoma (KB) cell line. Homo sapiens 12.1 ug.mL-1
In vitro antitumor activity in K-562 cell lines Homo sapiens 4.3 ug.mL-1
Growth inhibition in L1210 mouse leukemia cells after 24 h treatment Mus musculus 360.0 nM
Growth inhibition in L1210 mouse leukemia cells after 48 hr treatment Mus musculus 200.0 nM
In vitro inhibitory effect on growth of mouse leukemic L1210 cell lines. Mus musculus 0.32 ug.mL-1
Evaluated in vitro for the Cytotoxic activity in the L1210 cell culture screen at 1 uM Maximum cell kill in a 72-h period Mus musculus 79.8 %
Evaluated in vitro for the Cytotoxic activity in the L1210 cell culture screen at 10 uM Maximum cell kill in a 72-h period Mus musculus 81.2 %
Evaluated in vitro for the Cytotoxic activity in the L1210 cell culture screen at 100 uM Maximum cell kill in a 72-h period Mus musculus 90.3 %
Inhibition of cell growth of L1210 mouse Leukemia cells Mus musculus 300.0 nM
Concentration at 50 percent inhibition of cell growth against mouse leukemia 1210 cell line in vitro Mus musculus 0.36 ug.mL-1
Concentration required for the 50% inhibition of growth of L1210 mouse leukemia cells in culture Mus musculus 500.0 nM
In vitro cytotoxicity against murine Leukemia L1210 cells. Mus musculus 620.0 nM
In vitro growth inhibition of L1210 cells 24 hours after administration of compound Mus musculus 220.0 nM
In vitro growth inhibition of L1210 cells 48 hours after administration of compound Mus musculus 120.0 nM
In vitro growth inhibition of L1210 cells 8 hours after administration of compound Mus musculus 630.0 nM
Evaluated for the inhibition of tumor cell growth of murine leukemia malignant tumor cell line (L1210/0) Mus musculus 0.04 ug.mL-1
Effect on L1210/0 cells in culture Mus musculus 300.0 nM
The compound was evaluated for antitumoral activity against mouse leukemia cell line L1210/c after 72 hr of incubation Mus musculus 0.2 ug.mL-1
Concentration required for 50% inhibition of cell growth of L1210 leukemic cell lines in mouse. Mus musculus 0.32 ug.mL-1
In vitro inhibitory effect on growth of human T-cell acute lymphoblastic leukemic MOLT 4 cell lines. Homo sapiens 3.8 ug.mL-1
In vitro antitumor activity in MOLT-3 cell lines Homo sapiens 1.2 ug.mL-1
In vitro inhibitory activity against Human T-cell acute lymphoblastic leukemia (MOLT-4) cell line. Homo sapiens 3.8 ug.mL-1
Concentration required for 50% inhibition of cell growth of MOLT-4 leukemic cell lines in human. Homo sapiens 3.8 ug.mL-1
Evaluated for the inhibition of tumor cell growth of Human T-Lymphocyte cells (Molt4/C8) Homo sapiens 2.9 ug.mL-1
Percent inhibition against M5076 mouse reticulum cell sarcoma after administration at 10 mg/kg orally on day 20 Mus musculus 1.0 %
Percent inhibition against M5076 mouse reticulum cell sarcoma after administration at 20 mg/kg orally on day 20 Mus musculus 6.0 %
Percent inhibition against M5076 mouse reticulum cell sarcoma after administration at 30 mg/kg orally on day 20 Mus musculus 9.0 %
Percent inhibition against M5076 mouse reticulum cell sarcoma after administration at 40 mg/kg orally on day 20 Mus musculus 17.0 %
Percent inhibition against M5076 mouse reticulum cell sarcoma after administration at 50 mg/kg orally on day 20 Mus musculus 28.0 %
Percentage inhibition as antitumor activity in carcinoma CF1 male mice. Mus musculus 0.0 %
The compound was evaluated for antitumoral activity against human melanoma cell line P36 after 72 hr of incubation Homo sapiens 11.0 ug.mL-1
In vitro inhibitory activity against Human melanoma (P-36) cell line. Homo sapiens 10.7 ug.mL-1
In vitro inhibitory activity against growth of Human pancreas epitheloid carcinoma (PANC-1) cells Homo sapiens 0.22 ug.mL-1
IIn vitro antitumor activity in PHA-Ly cell lines Homo sapiens 1.4 ug.mL-1
In vitro inhibitory activity against Human lung squamous cell carcinoma (PC-10) cell line. Homo sapiens 100.0 ug.mL-1
In vitro inhibitory activity against Human lung adenocarcinoma (PC-14) cell line. Homo sapiens 10.0 ug.mL-1
In vitro inhibitory activity against growth of Human lung adenocarcinoma (PC-8) cells Homo sapiens 0.42 ug.mL-1
Concentration at 50 percent inhibition of cell growth against human cancer PC10 cell line in vitro Homo sapiens 42.0 ug.mL-1
In vitro inhibitory effect on growth of human lung squamous cell carcinoma cell lines (PC10). Homo sapiens 100.0 ug.mL-1
Concentration required for 50% inhibition of human lung squamous cell carcinoma PC10 solid cell lines. Homo sapiens 100.0 ug.mL-1
Concentration required for 50% inhibition of human lung squamous cell carcinoma PC14 solid cell lines. Homo sapiens 10.0 ug.mL-1
In vitro inhibitory activity against growth of Human lung squamous-cell carcinoma (QG-56) cells Homo sapiens 0.18 ug.mL-1
In vitro inhibitory activity against growth of Human lung small cell carcinoma (QG-90) cells Homo sapiens 0.22 ug.mL-1
In vitro inhibitory activity against growth of Human myeloma (RPMI 8226) cells Homo sapiens 0.07 ug.mL-1
In vitro inhibitory activity against growth of Human osteogenic sarcoma (Saos-2) cells Homo sapiens 0.78 ug.mL-1
Concentration required for 50% inhibition of human lung squamous cell carcinoma SW 480 solid cell lines. Homo sapiens 3.3 ug.mL-1
In vitro inhibitory activity against Human colon adenocarcinoma (SW-480) cell line. Homo sapiens 3.3 ug.mL-1
The compound was evaluated for antitumoral activity against human cancer cell line SW480 after 72 hr of incubation Homo sapiens 6.0 ug.mL-1
In vitro inhibitory effect on growth of human colon adenocarcinoma cell lines (SW480). Homo sapiens 3.3 ug.mL-1
Antitumor activity against lung carcinoma cell line (SK-MES-1) Homo sapiens 310.0 nM
Inhibitory concentration of compound for cytotoxicity against SK-MEL-2 human melanoma cells was determined Homo sapiens 0.63 ug.mL-1
Inhibitory concentration of compound for cytotoxicity against SK-OV-3 human ovarian cells was determined Homo sapiens 0.03 ug.mL-1
The compound was evaluated for antitumoral activity against human cancer cell line T24 after 72 hr of incubation Homo sapiens 6.0 ug.mL-1
In vitro inhibitory effect on growth of human bladder transitional-carcinoma cell lines (T24). Homo sapiens 6.1 ug.mL-1
Concentration required for 50% inhibition of human lung squamous cell carcinoma T24 solid cell lines. Homo sapiens 6.1 ug.mL-1
In vitro inhibitory activity against Human esophagus adenocarcinoma (TE-2) cell line. Homo sapiens 3.9 ug.mL-1
In vitro inhibitory effect on growth of human esophagus adenocarcinoma cell lines (TE2). Homo sapiens 3.9 ug.mL-1
Concentration required for 50% inhibition of human lung squamous cell carcinoma TE2 solid cell lines. Homo sapiens 3.9 ug.mL-1
In vitro inhibitory activity against Human bladder transitional-cell carcinoma (T-24) cell line. Homo sapiens 6.1 ug.mL-1
Tested for cytotoxicity against antigen negative T-24 bladder carcinoma cells having only 3-5% antigen expression Homo sapiens 0.5 ug.mL-1
In vitro antitumor activity in U-937 cell lines Homo sapiens 0.5 ug.mL-1
In vitro inhibitory activity against Human histiocytic lymphoma (U-937) cell line. Homo sapiens 3.5 ug.mL-1
In vitro inhibitory activity against growth of Human histocytic lymphoma (U937) cells Homo sapiens 0.11 ug.mL-1
Concentration required for 50% inhibition of cell growth of U937 leukemic cell lines in human. Homo sapiens 3.5 ug.mL-1
Concentration required to inhibit 50% of cell growth on murine L1210 cells. Mus musculus 280.0 nM
Concentration required to inhibit 50% of cell growth on murine P388 D1 cells. Mus musculus 490.0 nM
Cytotoxicity against mouse L1210/0 cells after 48 hrs Mus musculus 310.0 nM
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Homo sapiens 160.0 nM
Antitumor activity in mouse implanted with S180 cells at 50 mg/kg, ip after 2 days Mus musculus 80.4 %
Cytotoxicity against Vero cells Chlorocebus sabaeus 200.0 nM
Growth inhibition of DLA cells at 62.5 ug/mL after 3 hrs Mus musculus 100.0 %
Growth inhibition of DLA cells at 31.25 ug/mL after 3 hrs Mus musculus 100.0 %
Growth inhibition of EAC cells at 500 ug/mL after 3 hrs Mus musculus 100.0 %
Growth inhibition of EAC cells at 250 ug/mL after 3 hrs Mus musculus 100.0 %
Growth inhibition of DLA cells at 15.63 ug/mL after 3 hrs Mus musculus 73.68 %
Growth inhibition of DLA cells at 7.81 ug/mL after 3 hrs Mus musculus 65.79 %
Growth inhibition of DLA cells at 3.91 ug/mL after 3 hrs Mus musculus 42.11 %
Growth inhibition of EAC cells at 15.63 ug/mL after 3 hrs Mus musculus 60.71 %
Growth inhibition of EAC cells at 7.81 ug/mL after 3 hrs Mus musculus 32.14 %
Growth inhibition of EAC cells at 3.91 ug/mL after 3 hrs Mus musculus 17.86 %
Cytotoxicity against human Hep 3B cells by MTT microassay Homo sapiens 600.0 nM
Cytotoxicity against human HT29 cells by MTT microassay Homo sapiens 600.0 nM
Antiproliferative activity against human MCF7 cells after 72 hrs Homo sapiens 300.0 nM
Cytotoxicity against human MCF7 cells at 50 uM after 48 hrs Homo sapiens 20.0 %
Cytotoxicity against human DU145 cells at 50 uM after 48 hrs Homo sapiens 31.0 %
Cytotoxicity against human SW620 cells at 50 uM after 48 hrs Homo sapiens 41.0 %
Cytotoxicity against human 502713 cells at 50 uM after 48 hrs Homo sapiens 25.0 %
Cytotoxicity against human HT29 cells at 50 uM after 48 hrs Homo sapiens 36.0 %
Antitumor activity in B16 cells xenografted ICR mouse assessed as tumor growth inhibition at 25 mg/kg, iv after 11 days Mus musculus 72.4 %
Cytostatic activity against mouse L1210 cells Mus musculus 280.0 nM
Cytotoxicity against human A549 cells by MTT assay Homo sapiens 0.18 ug.mL-1
Cytotoxicity against human Bel 7402 cells by MTT assay Homo sapiens 0.54 ug.mL-1
Cytotoxicity against human BGC 823 cells by MTT assay Homo sapiens 0.7 ug.mL-1
Cytotoxicity against human HCT8 cells by MTT assay Homo sapiens 0.54 ug.mL-1
Cytotoxicity against human A2780 cells by MTT assay Homo sapiens 0.65 ug.mL-1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Homo sapiens 230.0 nM
Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay Mus musculus 310.0 nM
Cytotoxicity against human Hep3B cells by MTT assay Homo sapiens 600.0 nM
Cytotoxicity against human HT29 cells by MTT assay Homo sapiens 600.0 nM
Antitumor activity in mouse sarcoma 180 cells transplanted in Kunming mouse assessed as inhibition of tumor weight at 20 mg/kg, ip after 7 days relative to control Mus musculus 63.8 %
Growth inhibition of human HaCaT cells after 72 hrs by MTT assay Homo sapiens 400.0 nM
Cytotoxicity against human KB cells by MTT assay Homo sapiens 4.46 nM
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay Homo sapiens 690.0 nM
Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay Mus musculus 609.0 nM
Antiproliferative activity against mouse Colon 26-L5 cells assessed as cell viability after 72 hrs by MTT assay Mus musculus 500.0 nM
Antiproliferative activity against mouse B16-BL6 cells assessed as cell viability after 72 hrs by MTT assay Mus musculus 600.0 nM
Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay Homo sapiens 6.3 ug.mL-1
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay Homo sapiens 10.0 ug.mL-1
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay Homo sapiens 10.0 ug.mL-1
Antiproliferative activity against human HT1080 cells by MTT assay Homo sapiens 0.29 ug.mL-1
Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay Mus musculus 0.07 ug.mL-1
Antitumor activity in mouse B16 cell xenografted mouse at 20 mg/kg/day, iv after 4 days Mus musculus 73.5 %
Antitumor activity against mouse P388 cells Mus musculus 0.02 ug.mL-1
Antitumor activity against human A549 cells Homo sapiens 0.1 ug.mL-1
Antitumor activity against human HT-29 cells Homo sapiens 0.1 ug.mL-1
Antitumor activity against human SK MEL28 cells Homo sapiens 0.1 ug.mL-1
Cytotoxicity against human HepG2 cells by MTT assay Homo sapiens 1.3 ug.mL-1
Cytotoxicity against human KB cells Homo sapiens 0.93 ug.mL-1
Cytotoxicity against human HeLa S3 cells Homo sapiens 0.44 ug.mL-1
Growth inhibition of embryonic cells of stage 8 Xenopus laevis blastulae at 10 ug/mL Xenopus laevis 47.0 %
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy Homo sapiens 0.9 %
Cytotoxicity against human MCF7 cells by MTT assay Homo sapiens 0.0012 ug.mL-1
Cytotoxicity against human Hep3B cells by MTT assay Homo sapiens 0.072 ug.mL-1
Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay Mus musculus 460.0 nM
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Homo sapiens 770.0 nM
Antiproliferative activity against mouse L1210 cells after 2 days by MTT assay Mus musculus 690.0 nM
Cytotoxicity against human Bel7404 after 24 hrs by MTT assay Homo sapiens 0.2 ug.mL-1
Cytotoxicity against human A549 after 24 hrs by MTT assay Homo sapiens 0.2 ug.mL-1
Cytotoxicity against human BGC823 after 24 hrs by MTT assay Homo sapiens 0.2 ug.mL-1
Cytotoxicity against human HCT8 after 24 hrs by MTT assay Homo sapiens 0.2 ug.mL-1
Cytotoxicity against human A2780 after 24 hrs by MTT assay Homo sapiens 0.2 ug.mL-1
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Homo sapiens 300.0 nM
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay Homo sapiens 600.0 nM
Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Homo sapiens 16.0 nM
Antiproliferative activity against human A431 cells after 48 hrs by MTT assay Homo sapiens 18.0 nM
Cytotoxicity against human A549 cells by SRB assay Homo sapiens 2.0 ug.mL-1
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Homo sapiens 0.67 ug.mL-1
Cytotoxicity against human HeLa cells after 48 hrs by SRB assay Homo sapiens 1.01 ug.mL-1
Cytotoxicity against human U251 cells at 50 uM after 48 hrs by SRB assay Homo sapiens 64.2 %
Cytotoxicity against human PC3 cells at 50 uM after 48 hrs by SRB assay Homo sapiens 45.4 %
Cytotoxicity against human K562 cells at 50 uM after 48 hrs by SRB assay Homo sapiens 73.7 %
Cytotoxicity against human HCT15 cells at 50 uM after 48 hrs by SRB assay Homo sapiens 71.3 %
Cytotoxicity against human MCF7 cells at 50 uM after 48 hrs by SRB assay Homo sapiens 65.1 %
Cytotoxicity against human SK-LU-1 cells at 50 uM after 48 hrs by SRB assay Homo sapiens 70.5 %
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Homo sapiens 440.0 nM
Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay Mus musculus 410.0 nM
Antitumor activity against human MOLT4 cells after 24 hrs by MTT assay Homo sapiens 30.0 nM
Antitumor activity against mouse S180 cells transplanted in Kunming mouse assessed as inhibition of tumor growth at 50 mg/kg/day, iv for 2 days Mus musculus 80.7 %
Cytotoxicity against human SGC7901 after 48 hrs by MTT assay Homo sapiens 7.38 ug.mL-1
Antiviral activity against Influenza A virus H5N1 Vietnam/1203/2004H infected in MDCK cells Influenza A virus (A/Viet Nam/1203/2004(H5N1)) 26.0 ug.mL-1
Antiviral activity against Influenza B virus Florida/4/2006 infected in MDCK cells Influenza B virus (B/Florida/4/2006) 23.0 ug.mL-1
Cytotoxicity against MDCK cells Canis lupus familiaris 100.0 ug.mL-1
Antitumor activity against mouse EAC cells xenografted in BALB/C mouse assessed as inhibition of tumor growth at 10 mg/kg, ip administered every 3 days measured on day 7 relative to control Mus musculus 41.7 %
Antitumor activity against mouse EAC cells xenografted in BALB/C mouse assessed as inhibition of tumor growth at 10 mg/kg, ip administered every 3 days measured on day 15 relative to control Mus musculus 57.6 %
Antitumor activity against mouse EAC cells xenografted in BALB/C mouse assessed as reduction of tumor weight at 10 mg/kg, ip administered every 3 days measured on day 15 relative to control Mus musculus 46.1 %
Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay Homo sapiens 7.38 ug.mL-1
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Homo sapiens 2.48 ug.mL-1
Cytotoxicity against human A431 cells after 48 hrs by MTT assay Homo sapiens 2.17 ug.mL-1
Growth inhibition of human MDA-MB-231 cells at 3 uM after 96 hrs by sulforhodamine B assay relative to control Homo sapiens 3.3 %
Growth inhibition of human MDA-MB-231 cells at 5 uM after 96 hrs by sulforhodamine B assay relative to control Homo sapiens 41.6 %
Antiproliferative activity against human SGC7901 cells after 48 hrs by MTT assay Homo sapiens 7.36 ug.mL-1
Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay Homo sapiens 300.0 nM
PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi using a modified counterscreen. (Class of assay: confirmatory) None 378.0 nM
Cytotoxicity against human U2OS cells after 36 hrs by MTT assay Homo sapiens 7.2 ug.mL-1
Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay Homo sapiens 34.0 ug.mL-1
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Homo sapiens 14.1 ug.mL-1
Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay Homo sapiens 25.0 ug.mL-1
Cytotoxicity against human HepG2 cells assessed as loss of cell monolayers after 96 hrs Homo sapiens 8.6 ug.mL-1
Cytotoxicity against human WI38 cells assessed as loss of cell monolayers after 96 hrs Homo sapiens 3.2 ug.mL-1
Cytotoxicity against african green monkey Vero cells assessed as loss of cell monolayers after 96 hrs Chlorocebus sabaeus 6.5 ug.mL-1
Cytotoxicity against human MCF7 cells assessed as loss of cell monolayers after 96 hrs Homo sapiens 2.3 ug.mL-1
Cytotoxicity against mouse L1210 cells after 2 days by coulter counter analysis Mus musculus 560.0 nM
Cytotoxicity against human HeLa cells after 4 days by coulter counter analysis Homo sapiens 570.0 nM
Cytostatic activity against mouse L1210 cells after 2 days by coulter counting analysis Mus musculus 560.0 nM
Cytostatic activity against mouse FM3A cells after 2 days by coulter counting analysis Mus musculus 180.0 nM
Cytostatic activity against human HeLa cells after 3 days by coulter counting analysis Homo sapiens 450.0 nM
Cytostatic activity against mouse L1210 cells in presence of 500 uM uridine Mus musculus 620.0 nM
Cytostatic activity against mouse L1210 cells in presence of 500 uM uracil Mus musculus 470.0 nM
Cytostatic activity against human HeLa cells in presence of 20 uM 2'-deoxyuridine Homo sapiens 180.0 nM
Inhibition of DNA synthesis in mouse L1210 cells assessed as [6-3H]2'-deoxyuridine incorporation in to DNA by liquid scintillation counting Mus musculus 970.0 nM
Inhibition of DNA synthesis in mouse L1210 cells assessed as [6-3H]2'-deoxyuridine incorporation in to DNA preincubated for 24 hrs by liquid scintillation counting Mus musculus 370.0 nM
Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting Mus musculus 220.0 nM
Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting Mus musculus 20.0 nM
Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 hrs by liquid scintillation counting Mus musculus 600.0 nM
Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting Mus musculus 60.0 nM
Cytotoxicity against mouse EAC cells assessed as cell viability using trypan blue staining after 2 hrs by hemocytometer analysis Mus musculus 1.5 ug.mL-1
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability at 100 ug/mL after 48 hrs by MTT assay Homo sapiens 7.0 %
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability at 50 ug/mL after 48 hrs by MTT assay Homo sapiens 0.0 %
Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability at 25 ug/mL after 48 hrs by MTT assay Homo sapiens 0.0 %
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Homo sapiens 0.0027 nM
Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay Mus musculus 0.0017 nM
Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay Mus musculus 0.0011 nM
Cytotoxicity against human KB cells after 72 hrs by MTT assay Homo sapiens 0.0077 nM
Antitumor activity against mouse S180 cells xenografted in KM mouse assessed as tumor weight inhibition rate at 25 mg/kg, ip administered qd for 9 days measured on 10th day Mus musculus 46.5 %
Inhibition of RNA synthesis in Mucor mucedo IFO 7684 assessed as [8-14C]-adenine uptake into acid-insoluble fractions at 0.77 mM after 25 mins by liquid scintillation counting Mucor mucedo 75.0 %
Inhibition of DNA synthesis in Mucor mucedo IFO 7684 assessed as [8-14C]-adenine uptake into acid-insoluble fractions at 0.77 mM after 25 mins by liquid scintillation counting Mucor mucedo 61.0 %
Cytotoxicity against human MCF10A cells after 6 days by SRB colorimetric assay Homo sapiens 730.0 nM
Cytotoxicity against rat IEC-6 cells after 6 days by SRB colorimetric assay Rattus norvegicus 660.0 nM
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Homo sapiens 23.31 ug.mL-1
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Homo sapiens 31.02 ug.mL-1
Antiproliferative activity against human SW1116 cells after 48 hrs by MTT assay Homo sapiens 28.52 ug.mL-1
Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Homo sapiens 17.37 ug.mL-1
Cytotoxicity against human A549 cells after 3 days by MTT assay Homo sapiens 420.0 nM
Cytostatic activity against mouse L1210 cells Mus musculus 490.0 nM
Cytostatic activity against human HeLa cells Homo sapiens 540.0 nM
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Homo sapiens 0.67 ug.mL-1
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Homo sapiens 6.0 ug.mL-1
Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay Homo sapiens 8.6 ug.mL-1
Cytotoxicity against human WI38 cells after 96 hrs by MTT assay Homo sapiens 3.2 ug.mL-1
Cytotoxicity against african green monkey Vero cells after 96 hrs by MTT assay Chlorocebus sabaeus 6.5 ug.mL-1
Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Homo sapiens 2.3 ug.mL-1
Cytotoxicity against human A549 cells by MTT assay Homo sapiens 0.32 ug.mL-1
Cytotoxicity against human HeLa cells by MTT assay Homo sapiens 0.14 ug.mL-1
Cytotoxicity against human MCF7 cells by MTT assay Homo sapiens 0.22 ug.mL-1
Cytotoxicity against human HepG2 cells by MTT assay Homo sapiens 0.0082 ug.mL-1
Cytotoxicity against human SMMC7721 cells by MTT assay Homo sapiens 0.023 ug.mL-1
Cytotoxicity against human MKN45 cells by MTT assay Homo sapiens 0.36 ug.mL-1
Cytostatic activity against mouse L1210 cells after 2 days by coulter counter analysis Mus musculus 490.0 nM
Cytostatic activity against human HeLa cells after 3 days by coulter counter analysis Homo sapiens 540.0 nM
Cytostatic activity against human HaCaT cells after 72 hrs by MTT assay Homo sapiens 300.0 nM
Antitumor activity against human BxPC3 cells xenografted in SCID mouse assessed as reduction in tumor volume at 17 mg/kg, ip twice a week Homo sapiens 3.25 %
Cytotoxicity against human NCI-H69 cells after 3 days MTT assay Homo sapiens 280.0 ug.mL-1
Cytotoxicity against human PZ-HPV-7 cells after 3 days MTT assay Homo sapiens 170.0 ug.mL-1
Cytotoxicity against human MCF7 cells after 3 days MTT assay Homo sapiens 690.0 ug.mL-1
Cytotoxicity against human HeLa cells after 3 days MTT assay Homo sapiens 40.0 ug.mL-1
Cytotoxicity against mouse EAC after 2 hrs by trypan blue staining based hemocytometer analysis Mus musculus 97.3 ug
Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay Homo sapiens 9.1 ug.mL-1
Cytotoxicity against human WI38 cells after 96 hrs by MTT assay Homo sapiens 4.0 ug.mL-1
Cytotoxicity against African green monkey Vero cells after 96 hrs by MTT assay Chlorocebus sabaeus 6.4 ug.mL-1
Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Homo sapiens 2.5 ug.mL-1
Antitumor activity against human MX1 cells xenografted in Balb/cA JcL mouse at 15 mg/kg/day dosed as as continuous infusion measured on day 15 Homo sapiens 20.0 %
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Homo sapiens 280.0 nM
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Homo sapiens 60.0 nM
Antitumor activity against human MX1 cells xenografted in Balb/cA JcL-nu mouse assessed as tumor growth inhibition at 15 mg/kg/day, po for 14 days dosed as continuous infusion using osmotic pump and measured twice a week relative to untreated control Homo sapiens 20.0 %
Cytostatic activity against human HeLa cells after 72 hrs by cell counting Homo sapiens 540.0 nM
Cytostatic activity against thymidine-kinase deficient human HeLa cells after 72 hrs by cell counting Homo sapiens 230.0 nM
Cytostatic activity against thymidine-kinase deficient mouse L1210 cells after 48 hrs by cell counting Mus musculus 320.0 nM
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay Homo sapiens 7.2 ug.mL-1
Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay Homo sapiens 8.2 ug.mL-1
Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay Homo sapiens 8.7 ug.mL-1
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Homo sapiens 9.3 ug.mL-1
Cytotoxicity against Homo sapiens (human) HL60 cells by MTT assay Homo sapiens 25.4 ug.mL-1
Cytotoxicity against Homo sapiens (human) SGC7901 cells by MTT assay Homo sapiens 0.58 ug.mL-1
Cytotoxicity against Homo sapiens (human) HT-29 cells by MTT assay Homo sapiens 10.26 ug.mL-1
Antiproliferative activity against Homo sapiens (human) A431 cells at 5 uM measured after 72 hr by MTT assay Homo sapiens 30.7 %
Antiproliferative activity against Homo sapiens (human) PC3 cells at 5 uM measured after 72 hr by MTT assay Homo sapiens 41.1 %
Antitumor activity against mouse HepS cells allografted in Kunming mouse assessed as inhibition of tumor growth at 25 mg/kg, iv bid administered 2 days once for 4 times Mus musculus 70.31 %
Cytotoxicity against human HeLa cells after 24 hrs by MTT assay Homo sapiens 1.28 ug.mL-1
Cytotoxicity against human U937 cells after 24 hrs by MTT assay Homo sapiens 0.87 ug.mL-1
Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay Homo sapiens 4.03 ug.mL-1
Cytotoxicity against human THP1 cells after 24 hrs by MTT assay Homo sapiens 0.54 ug.mL-1
Cytotoxicity against human ACHN cells after 24 hrs by MTT assay Homo sapiens 9.874 ug.mL-1
Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay Homo sapiens 4.562 ug.mL-1
Cytotoxicity against human EC9706 cells after 72 hrs by MTT assay Homo sapiens 320.0 nM
Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Homo sapiens 970.0 nM
Antitumor activity against mouse H22 cells transfected in mouse assessed as inhibition of tumor growth at 153.8 umol/kg, ip after 14 days relative to vehicle-treated control Mus musculus 57.55 %
Antitumor activity against mouse EAC cells by trypan blue exclusion assay Mus musculus 380.0 nM
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Homo sapiens 0.8 ug.mL-1
Cytotoxicity against human Hep cells after 48 hrs by SRB assay Homo sapiens 500.0 nM
Cytotoxicity against human QSG7701 cells after 48 hrs by CCK-8 assay Homo sapiens 600.0 nM
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Homo sapiens 0.887 ug.mL-1
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay Homo sapiens 2.48 ug.mL-1
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM Cricetulus griseus 86.84 %
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM Cricetulus griseus 91.17 %
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by MTT assay Homo sapiens 25.6 ug.mL-1
Cytotoxicity against human A549 cells after 48 hrs by MTT assay Homo sapiens 24.87 ug.mL-1
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay Homo sapiens 20.03 ug.mL-1
Cytotoxicity against mouse L1210 cells assessed as reduction in cell number after 48 hrs by cell counting assay Mus musculus 330.0 nM
Cytotoxicity against human HeLa cells assessed as reduction in cell number after 72 hrs by cell counting assay Homo sapiens 540.0 nM
Cytotoxicity against human A549 cells assessed as growth inhibition measured at 48 hrs by SRB assay Homo sapiens 980.0 nM
Cytotoxicity against mouse E0771 cells after 3 days by SRB assay Mus musculus 280.0 nM
Antitumor activity against mouse B16 cells transplanted in ICR mouse assessed as tumor growth inhibition at 30 mg/kg, iv administered 7 days post tumor transplantation Mus musculus 70.3 %
Cytotoxicity against human Hep cells after 48 hrs by SRB assay Homo sapiens 500.0 nM
Cytotoxicity against mouse B16F10 cells assessed as inhibition of proliferation after 72 hrs by MTT assay Mus musculus 870.0 nM
Cytotoxicity against human THP1 cells after 48 hrs by SRB assay Homo sapiens 40.0 nM
Cytotoxicity against human A549 cells after 48 hrs by SRB assay Homo sapiens 10.0 nM
Cytostatic activity against mouse L1210 cells after 48 hrs by Coulter counting Mus musculus 330.0 nM
Antitumor activity against mouse B16 cells allografted in ICR mouse assessed as tumor growth inhibition at 30 mg/kg, iv administered 7 days post inoculation measured at day 25 of tumor transplantation Mus musculus 70.3 %
Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Homo sapiens 500.0 nM
Cytostatic activity against mouse L1210 cells assessed as inhibition of proliferation after 48 hrs by Coulter cell counting method Mus musculus 330.0 nM
Cytostatic activity against human HeLa cells assessed as inhibition of proliferation after 72 hrs by Coulter cell counting method Homo sapiens 540.0 nM
Anticancer activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Homo sapiens 4.1 ug.mL-1
Anticancer activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Homo sapiens 12.1 ug.mL-1
Anticancer activity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay Homo sapiens 4.8 ug.mL-1
Anticancer activity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Homo sapiens 5.7 ug.mL-1
Anticancer activity against mouse LL/2 cells assessed as growth inhibition after 48 hrs by MTT assay Mus musculus 2.9 ug.mL-1
Antiproliferative activity against human HCT8 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Homo sapiens 910.0 nM
In vivo antitumor activity against mouse B16 cells xenografted in mouse assessed as tumor growth inhibitory ratio at 30 mg/kg, ip administered after 7 days of tumor transplantation measured at 25th day after tumor inoculation Mus musculus 70.3 %
Cytotoxicity against human T3M4 cells by crystal violet staining Homo sapiens 330.0 nM
Cytotoxicity against mouse L1210 cells assessed as inhibition of cell proliferation Mus musculus 330.0 nM
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation Homo sapiens 540.0 nM
Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Homo sapiens 860.0 nM
Anticancer activity against human HepG2 cells at 40 ug/ml after 72 hrs by MTT assay Homo sapiens 68.2 %
Anticancer activity against human MCF7 cells at 40 ug/ml after 72 hrs by MTT assay Homo sapiens 68.2 %
Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay Homo sapiens 790.0 nM
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Homo sapiens 35.99 ug.mL-1
Cytotoxicity against human BCG823 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Homo sapiens 17.41 ug.mL-1
Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Homo sapiens 10.41 ug.mL-1
Antitumor activity against mouse B16F10 cells xenografted in mouse assessed as inhibition of tumor growth at 20 mg/kg, iv after 25 days Mus musculus 68.2 %
Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay Homo sapiens 520.0 nM
Cytotoxicity against human MDST8 cells after 72 hrs by CCK8 assay Homo sapiens 64.0 nM
Cytotoxicity against human MDST8 cells at 1 x 10'-5 M after 72 hrs by CCK8 assay Homo sapiens 83.0 %
Cytotoxicity against human MCF7 cells at 1 x 10'-5 M after 72 hrs by CCK8 assay Homo sapiens 60.0 %
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Homo sapiens 90.0 nM
Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay Homo sapiens 790.0 nM
Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B assay Homo sapiens 500.0 nM
Cytotoxicity against human THP1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B assay Homo sapiens 10.0 nM
Antiproliferative activity against human PANC1 cells after 72 hrs by WST-8 assay Homo sapiens 400.0 nM
Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay Homo sapiens 900.0 nM
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay Homo sapiens 30.0 nM
Cytotoxicity against human PC3 cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay Homo sapiens 30.0 nM
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay Homo sapiens 10.8 ug.mL-1
Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay Homo sapiens 10.72 ug.mL-1
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay Homo sapiens 9.23 ug.mL-1
Cytotoxicity against human BCG823 cells assessed as cell growth inhibition after 72 hrs by MTT assay Homo sapiens 10.89 ug.mL-1
Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay Homo sapiens 10.5 ug.mL-1
Cytotoxicity against human HL7702 cells assessed as cell growth inhibition after 72 hrs by MTT assay Homo sapiens 14.53 ug.mL-1
Cytotoxicity against human Bel7402 cells at 10'-5 M by MTT assay relative to control Homo sapiens 70.57 %
Cytotoxicity against human HCT8 cells at 10'-5 M by MTT assay relative to control Homo sapiens 70.38 %
Cytotoxicity against human A549 cells at 10'-5 M by MTT assay relative to control Homo sapiens 68.32 %
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay Homo sapiens 4.8 ug.mL-1
Inhibition of wild type PI3K p110alpha/p85alpha niSH2 (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduction in PIP3 formation at 100 uM using PIP2 as substrate after 45 mins by fluorescence polarization assay relative to control Homo sapiens 25.0 %
Inhibition of full length PI3Kalpha (unknown origin) assessed as reduction in PIP3 formation at 100 uM using PIP2 as substrate after 45 mins by fluorescence polarization assay relative to control Homo sapiens 25.0 %
Anti-proliferative activity against mouse L1210 cells measured after 48 hrs by coulter counter method Mus musculus 330.0 nM
Anti-proliferative activity against human HeLa cells measured after 4 days by coulter counter method Homo sapiens 540.0 nM
Antiproliferative activity against human CFPAC-1 cells after 72 hrs by MTT assay Homo sapiens 140.0 nM
Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay Homo sapiens 80.0 nM
Antiproliferative activity against human WI38 cells after 72 hrs by MTT assay Homo sapiens 940.0 nM
Antiproliferative activity against human CFPAC-1 cells after 72 hrs by MTT assay Homo sapiens 140.0 nM
Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay Homo sapiens 80.0 nM
Antiproliferative activity against human WI38 cells after 72 hrs by MTT assay Homo sapiens 940.0 nM
Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay Homo sapiens 80.0 nM
Antiproliferative activity against human CFPAC-1 cells after 72 hrs by MTT assay Homo sapiens 140.0 nM
Cytotoxicity against human WI38 cells after 72 hrs by MTT assay Homo sapiens 940.0 nM
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Homo sapiens 66.0 ug.mL-1
Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Homo sapiens 178.0 ug.mL-1
Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Homo sapiens 201.0 ug.mL-1
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Homo sapiens 237.0 ug.mL-1
Anticlonogenic activity against human A549 cells assessed as inhibition of clonogenic growth at 3 uM incubated for 2 days followed by replacement of growth media and measured after 8 days by crystal violet staining-based assay relative to control Homo sapiens 38.0 %
Anticlonogenic activity against human A549 cells assessed as inhibition of clonogenic growth at 9 uM incubated for 2 days followed by replacement of growth media and measured after 8 days by crystal violet staining-based assay relative to control Homo sapiens 70.0 %
Antiproliferative activity against human SMMC7721 cells after 48 hrs by MTT assay Homo sapiens 19.25 ug.mL-1
Antiproliferative activity against human SGC7901 cells after 48 hrs by MTT assay Homo sapiens 16.03 ug.mL-1
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay Homo sapiens 1.8 ug.mL-1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Homo sapiens 2.19 ug.mL-1
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Homo sapiens 3.82 ug.mL-1
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Homo sapiens 2.24 ug.mL-1
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Homo sapiens 430.0 nM
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Homo sapiens 530.0 nM
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 96 hrs Homo sapiens 8.6 ug.mL-1
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 96 hrs Homo sapiens 3.2 ug.mL-1
Cytotoxicity against human SN12C cells assessed as decrease in cell viability after 96 hrs Homo sapiens 6.5 ug.mL-1
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 96 hrs Homo sapiens 2.3 ug.mL-1
Cytotoxicity against human NCI-H358 cells assessed as decrease in cell viability after 96 hrs Homo sapiens 6.9 ug.mL-1
Cytotoxicity against human MIAPaCa2 cells assessed as decrease in cell viability after 96 hrs Homo sapiens 3.5 ug.mL-1
Antiproliferative activity against human LS174T cells assessed as inhibition of cell proliferation at 10 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 82.3 %
Antiproliferative activity against human LS174T cells assessed as inhibition of cell proliferation at 1 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 6.5 %
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation at 1 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 11.6 %
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation at 10 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 82.9 %
Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation at 1 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 37.7 %
Antiproliferative activity against human Caco2 cells assessed as inhibition of cell proliferation at 10 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 60.2 %
Cytotoxicity against human HEL299 cells assessed as inhibition of cell proliferation at 10 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 64.6 %
Cytotoxicity against human HEL299 cells assessed as inhibition of cell proliferation at 1 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 12.1 %
Cytotoxicity against human BEAS2B cells assessed as inhibition of cell proliferation at 10 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 57.5 %
Cytotoxicity against human BEAS2B cells assessed as inhibition of cell proliferation at 1 uM after 4 days by Vi-Cell cell viability analyzer based method relative to control Homo sapiens 4.5 %
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human HL60 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by MTT assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by MTT assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human LS180 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human BxPC3 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiproliferative activity against human PANC1 cells assessed as inhibition of cell growth at 100 uM after 72 hrs by sulforhodamine B assay relative to control Homo sapiens 41.0 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Homo sapiens -3.59 %
Antiproliferative activity against human CFPAC-1 cells incubated for 72 hrs by MTT assay Homo sapiens 140.0 nM
Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay Homo sapiens 80.0 nM
Antiproliferative activity against human MCF7 cells by MTT assay Homo sapiens 30.0 ug.mL-1
Reduction in CDK1 mRNA expression in human HCT116 cells at 100 nM after 6 hrs hrs by SYBR green dye-based qRT-PCR analysis relative to control Homo sapiens 50.0 %
Cytotoxicity against human MCF7 cells Homo sapiens 9.74 ug.mL-1
Cytotoxicity against human HCT116 cells Homo sapiens 17.3 ug.mL-1
Cytotoxicity against human PC3 cells Homo sapiens 21.4 ug.mL-1
Antiproliferative activity against human DLD1 cells assessed as cell growth inhibition at 450 nM by MTT assay relative to control Homo sapiens 21.0 %
Antiproliferative activity against human NCI-N87 cells assessed as cell growth inhibition at 450 nM by MTT assay relative to control Homo sapiens 8.0 %
Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition at 450 nM by MTT assay relative to control Homo sapiens 17.0 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 7.68 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 17.78 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.04 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus 0.05 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.04 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus 0.05 %
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by SRB assay Homo sapiens 540.0 nM
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability by SRB assay Homo sapiens 540.0 nM
Cytotoxicity against human U251 cells assessed as reduction in cell viability by SRB assay Homo sapiens 540.0 nM
Anticancer activity against human MC38 cells xenografted in C57BL/6 mouse assessed as inhibition rate at 40 mg/kg, po administered once daily for 12 days relative to control Mus musculus 34.27 %
Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability at 10 uM incubated for 72 hrs by MTT assay relative to control Homo sapiens 65.3 %
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 10 uM incubated for 72 hrs by MTT assay relative to control Homo sapiens 41.9 %
Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 10 uM incubated for 72 hrs by MTT assay relative to control Homo sapiens 44.0 %
Antiproliferative activity against human SUIT-2 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Homo sapiens 910.0 nM
Antiproliferative activity against human Capan-1 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay Homo sapiens 470.0 nM
Antiproliferative activity against human PDAC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Homo sapiens 560.0 nM
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at 100 microM measured after 72 hrs by SRB assay Homo sapiens 89.29 %
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth at 100 microM measured after 72 hrs by SRB assay Homo sapiens 80.67 %
Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth at 100 microM measured after 72 hrs by SRB assay Homo sapiens 90.72 %
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Homo sapiens 690.0 nM
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Homo sapiens 520.0 nM
Antiproliferative activity against human MCF-7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Homo sapiens 590.0 nM
Antiproliferative activity against human CAL-27 cells assessed as cell viability measured after 72 hrs by MTT assay Homo sapiens 0.5 ug.mL-1
Antiproliferative activity against human SCC-9 cells assessed as cell viability measured after 72 hrs by MTT assay Homo sapiens 12.7 ug.mL-1

Cross References

Resources Reference
ChEBI 46345
ChEMBL CHEMBL185
DrugBank DB00544
DrugCentral 26
FDA SRS U3P01618RT
Human Metabolome Database HMDB0014684
Guide to Pharmacology 4789
KEGG C07649
PDB URF
PharmGKB PA128406956
PubChem 3385
SureChEMBL SCHEMBL3646
ZINC ZINC000038212689