EcoDrugPlus


Trade Names	ANTARA (MICRONIZED) FENOFIBRATE FENOFIBRATE (MICRONIZED) FENOGLIDE LIPIDIL LIPOFEN TRICOR TRICOR (MICRONIZED) TRIGLIDE
Synonyms	Antara Antara (micronized) Fenofibrate Fenofibrate (micronized) Fenofibrate delayed release Fenofibrate micronized Fenogal Fenoglide Lipantil Lipantil micro 200 Lipantil micro 267 Lipantil micro 67 Lipidil Lipofen NSC-281319
Status
Molecule Category	Free-form
ATC	C10AB05
UNII	U202363UOS
EPA CompTox	DTXSID2029874

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SubStructure

Threshold (%) >= 70


InChI Key	YMTINGFKWWXKFG-UHFFFAOYSA-N
Smiles	CC(C)OC(=O)C(C)(C)Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1
InChI	InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C20H21ClO4
Molecular Weight	360.84
AlogP	4.68
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	6.0
Polar Surface Area	52.6
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	25.0

Metabolites Network

Mechanism of Action	Action	Reference
Peroxisome proliferator-activated receptor alpha agonist	AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Auxiliary transport protein Fatty acid binding protein family	-	-	18-360	24-405	-
Enzyme Hydrolase	-	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3	570	-	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-10.8-90.21
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	0.2

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	82.56-90.21
Homo sapiens	-	-	-	-	-12-34.2
Mesocricetus auratus	-	-	-	-	30-77
Mus musculus	-	-	-	-	1.6-26.7
Rattus norvegicus	-	-	18-360	24-405	35-37

Target Conservation


Protein: Peroxisome proliferator-activated receptor alpha Description: Peroxisome proliferator-activated receptor alpha Organism : Homo sapiens Q07869 ENSG00000186951

Cross References

Resources	Reference
ChEBI	5001
ChEMBL	CHEMBL672
DrugBank	DB01039
DrugCentral	1152
FDA SRS	U202363UOS
Human Metabolome Database	HMDB0015173
Guide to Pharmacology	7186
KEGG	C07586
PharmGKB	PA449594
PubChem	3339
SureChEMBL	SCHEMBL4670
ZINC	ZINC000000584092

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

FENOFIBRATE

Structure

Physicochemical Descriptors

Metabolites Network

Pharmacology

Target Conservation

Related Entries

Cross References