FENOFIBRATE


Trade Names	ANTARA (MICRONIZED) FENOFIBRATE FENOFIBRATE (MICRONIZED) FENOGLIDE LIPIDIL LIPOFEN TRICOR TRICOR (MICRONIZED) TRIGLIDE
Synonyms	Antara Antara (micronized) Fenofibrate Fenofibrate (micronized) Fenofibrate delayed release Fenofibrate micronized Fenogal Fenoglide Lipantil Lipantil micro 200 Lipantil micro 267 Lipantil micro 67 Lipidil Lipofen NSC-281319 Supralip 160 Tricor Tricor (micronized) Triglide
Status
Molecule Category	UNKNOWN
ATC	C10AB05
UNII	U202363UOS
EPA CompTox	DTXSID2029874


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	YMTINGFKWWXKFG-UHFFFAOYSA-N
Smiles	CC(C)OC(=O)C(C)(C)Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1
InChI	InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C20H21ClO4
Molecular Weight	360.84
AlogP	4.68
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	6.0
Polar Surface Area	52.6
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	25.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action	Action	Reference
Peroxisome proliferator-activated receptor alpha agonist	AGONIST	DailyMed


Protein: Peroxisome proliferator-activated receptor alpha Description: Peroxisome proliferator-activated receptor alpha Organism : Homo sapiens Q07869 ENSG00000186951

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Auxiliary transport protein Fatty acid binding protein family	-	-	18-360	24-405	-
Enzyme Hydrolase	-	-	-	-
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C1A family	-	61000	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 1	2000-50000	1000	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3	570-41000	-	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-11-90
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	0
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	15300-41000	-	-	-

Related Entries

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Cross References

Resources	Reference
ChEBI	5001
ChEMBL	CHEMBL672
DrugBank	DB01039
DrugCentral	1152
FDA SRS	U202363UOS
Human Metabolome Database	HMDB0015173
Guide to Pharmacology	7186
KEGG	C07586
PharmGKB	PA449594
PubChem	3339
SureChEMBL	SCHEMBL4670
ZINC	ZINC000000584092

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).