Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes at 20 uM
|
Homo sapiens
|
3.0
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 50 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
100.0
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 25 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
80.0
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 5 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
50.0
%
|
|
Antitubercular activity against Mycobacterium bovis BCG at 10 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium bovis BCG
|
71.0
%
|
|
Antitubercular activity against Mycobacterium bovis BCG at 5 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium bovis BCG
|
50.0
%
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Ra at 10 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
67.0
%
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Ra at 5 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
50.0
%
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
|
Chlorocebus sabaeus
|
100.0
ug.mL-1
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate Alamar blue assay
|
Mycobacterium tuberculosis H37Rv
|
12.47
ug.mL-1
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 12.5 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
51.0
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 25 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
93.9
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 50 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
96.3
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 100 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
97.7
%
|
|
Inhibition of alanine racemase in Mycobacterium tuberculosis H37Rv assessed as remaining activity at MIC preincubated for 16 hrs followed by L-Ala-[13C]-[3H] addition measured over 8 hrs by LC-MS/MS analysis
|
Mycobacterium tuberculosis H37Rv
|
10.0
%
|
|
Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
6.25
ug.mL-1
|
|
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600)
|
Staphylococcus aureus subsp. aureus
|
14.71
%
|
|
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600)
|
Escherichia coli
|
1.47
%
|
|
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600)
|
Klebsiella pneumoniae
|
12.0
%
|
|
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600)
|
Pseudomonas aeruginosa
|
60.23
%
|
|
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600
|
Acinetobacter baumannii
|
25.21
%
|
|
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630
|
Candida albicans
|
1.72
%
|
|
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570)
|
Cryptococcus neoformans
|
-5.65
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
-2.21
%
|
|
Inhibition of Enterococcus faecalis JH2-2 C-terminal 6His-tagged DdlB expressed in Escherichia coli LMG194 at 10 uM preincubated for 30 mins followed by substrate addition and measured after 20 mins by Biomol Green reagent assay relative to control
|
Enterococcus faecalis
|
30.0
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
23.75
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
29.49
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.17
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.09
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.17
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.09
%
|
|
Antimycobacterial activity against Mycobacterium bovis BCG assessed as inhibition of bacterial growth at 10 ug/ml measured by microplate alamar blue assay
|
Mycobacterium tuberculosis variant bovis BCG
|
71.0
%
|
|
Antimycobacterial activity against Mycobacterium bovis BCG assessed as inhibition of bacterial growth at 5 ug/ml measured by microplate alamar blue assay
|
Mycobacterium tuberculosis variant bovis BCG
|
50.0
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as inhibition of bacterial growth at 10 ug/ml measured by microplate alamar blue assay
|
Mycobacterium tuberculosis
|
67.0
%
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as inhibition of bacterial growth at 5 ug/ml measured by microplate alamar blue assay
|
Mycobacterium tuberculosis
|
50.0
%
|
|