CHLORZOXAZONE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC M03BB03
UNII H0DE420U8G
EPA CompTox DTXSID9022813

Structure

InChI Key TZFWDZFKRBELIQ-UHFFFAOYSA-N
Smiles O=c1[nH]c2cc(Cl)ccc2o1
InChI
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H4ClNO2
Molecular Weight 169.57
AlogP 1.77
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Polar Surface Area 46.0
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 11.0

Pharmacology

Mechanism of Action Action Reference
Intermediate conductance calcium-activated potassium channel protein 4 opener OPENER PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - -1-115.26
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 6.8
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 103.62-115.26
Homo sapiens
- - - - -3.2-20.1
Mus musculus
- - - - 33.2
Rattus norvegicus
- - - - 0-77.3

Target Conservation

Protein: Intermediate conductance calcium-activated potassium channel protein 4
Description: Intermediate conductance calcium-activated potassium channel protein 4
Organism : Homo sapiens
O15554 ENSG00000104783

Cross References

Resources Reference
ChEBI 3655
ChEMBL CHEMBL1371
DrugBank DB00356
DrugCentral 626
FDA SRS H0DE420U8G
Human Metabolome Database HMDB0014500
Guide to Pharmacology 2322
KEGG C07931
PDB CLW
PharmGKB PA448971
PubChem 2733
SureChEMBL SCHEMBL35177
ZINC ZINC000084843283
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